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THRC - TRPA
UniProt: P00934 - P0A877
Length: 696
Sequences: 1052
Seq/Len: 1.72
I_Prob: 0.99

THRC - Threonine synthase
Paralog alert: 0.68 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: THRC
TRPA - Tryptophan synthase alpha chain
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: TRPA
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4ht3B:A:AContact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
287_Q 108_N 2.61 0.99
290_P 103_A 1.72 0.90
194_K 58_L 1.58 0.84
192_L 65_Q 1.32 0.65
32_P 58_L 1.23 0.55
290_P 107_F 1.22 0.54
214_I 58_L 1.14 0.45
197_F 58_L 1.13 0.45
87_A 33_S 1.04 0.34
205_A 180_A 1.03 0.33
162_I 214_I 1.00 0.31
291_K 54_F 0.98 0.28
36_P 159_D 0.94 0.25
314_E 43_A 0.93 0.23
275_V 169_Y 0.89 0.20
265_P 137_A 0.88 0.20
156_L 204_N 0.88 0.19
287_Q 29_G 0.85 0.17
32_P 232_I 0.85 0.17
308_N 136_S 0.85 0.17
34_D 157_N 0.84 0.17
373_F 79_A 0.84 0.16
343_L 215_S 0.83 0.15
51_F 100_L 0.81 0.14
293_T 209_L 0.81 0.14
75_R 85_L 0.81 0.14
122_A 195_H 0.80 0.13
39_S 134_E 0.79 0.13
146_Y 182_V 0.78 0.12
194_K 4_Y 0.78 0.12
260_K 236_A 0.78 0.12
285_D 55_S 0.77 0.12
331_V 192_P 0.77 0.12
111_G 143_A 0.76 0.11
30_F 107_F 0.75 0.11
93_V 147_N 0.75 0.11
37_E 215_S 0.75 0.10
227_F 54_F 0.74 0.10
105_A 59_A 0.74 0.10
76_V 21_P 0.74 0.10
224_C 219_Q 0.73 0.10
221_A 152_F 0.73 0.10
197_F 157_N 0.73 0.10
155_I 43_A 0.73 0.10
275_V 22_F 0.73 0.10
362_R 4_Y 0.73 0.09
271_A 193_L 0.72 0.09
169_L 51_G 0.72 0.09
311_R 229_A 0.72 0.09
43_I 222_A 0.72 0.09
297_L 157_N 0.71 0.09
190_Q 58_L 0.71 0.09
345_E 257_V 0.71 0.09
168_K 157_N 0.70 0.08
155_I 202_E 0.70 0.08
230_V 87_L 0.70 0.08
148_L 177_L 0.70 0.08
360_A 21_P 0.69 0.08
374_L 105_L 0.69 0.08
238_R 79_A 0.69 0.08
297_L 31_E 0.69 0.08
129_I 178_S 0.69 0.08
254_T 48_L 0.69 0.07
79_A 46_D 0.69 0.07
272_A 166_I 0.69 0.07
294_Q 179_R 0.68 0.07
344_K 174_T 0.68 0.07
151_V 222_A 0.68 0.07
194_K 97_I 0.68 0.07
337_Q 123_V 0.68 0.07
93_V 33_S 0.68 0.07
53_T 166_I 0.68 0.07
152_K 6_S 0.68 0.07
26_N 67_A 0.68 0.07
110_G 162_L 0.67 0.07
146_Y 180_A 0.67 0.07
32_P 215_S 0.67 0.07
146_Y 170_G 0.67 0.07
149_P 21_P 0.67 0.07
239_N 236_A 0.66 0.07
294_Q 180_A 0.66 0.07
39_S 159_D 0.66 0.07
214_I 19_F 0.66 0.07
30_F 117_Q 0.66 0.07
224_C 221_K 0.66 0.07
152_K 182_V 0.66 0.07
344_K 113_E 0.66 0.06
205_A 75_G 0.66 0.06
368_G 48_L 0.65 0.06
386_V 159_D 0.65 0.06
234_P 201_K 0.65 0.06
204_V 180_A 0.65 0.06
230_V 145_R 0.64 0.06
129_I 28_P 0.64 0.06
101_G 129_A 0.64 0.06
266_V 257_V 0.64 0.06
288_W 118_C 0.64 0.06
258_L 205_A 0.64 0.06
110_G 125_S 0.64 0.06
105_A 178_S 0.64 0.06
229_A 137_A 0.64 0.06
105_A 180_A 0.64 0.06
343_L 174_T 0.64 0.06
77_R 82_F 0.63 0.06
146_Y 199_K 0.63 0.06
331_V 116_A 0.63 0.06
30_F 130_D 0.63 0.06
159_R 214_I 0.63 0.06
286_G 51_G 0.63 0.06
84_A 127_L 0.63 0.06
374_L 37_I 0.63 0.06
313_E 51_G 0.63 0.06
304_S 179_R 0.63 0.06
93_V 114_F 0.63 0.06
323_L 21_P 0.63 0.06
268_R 10_Q 0.63 0.06
32_P 129_A 0.63 0.06
265_P 9_A 0.63 0.06
368_G 151_I 0.63 0.06
34_D 177_L 0.63 0.06
190_Q 262_M 0.63 0.06
162_I 166_I 0.63 0.06
172_T 21_P 0.63 0.05
149_P 173_Y 0.63 0.05
318_R 67_A 0.62 0.05
243_V 113_E 0.62 0.05
386_V 223_A 0.62 0.05
315_L 133_V 0.62 0.05
334_E 86_A 0.62 0.05
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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