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HIS2 - HIS5
UniProt: P06989 - P60595
Length: 399
Sequences: 407
Seq/Len: 1.03
I_Prob: 0.00

HIS2 - Histidine biosynthesis bifunctional protein HisIE
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: HIS2
HIS5 - Imidazole glycerol phosphate synthase subunit HisH
Paralog alert: 0.89 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: HIS5 PABA
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution.

Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
158_A 181_R 1.34 0.00
174_S 78_L 1.09 0.00
154_G 181_R 1.07 0.00
148_Q 50_A 1.02 0.00
77_I 42_L 1.02 0.00
168_E 78_L 1.01 0.00
12_W 8_T 1.01 0.00
168_E 44_L 0.98 0.00
150_V 15_S 0.94 0.00
77_I 132_G 0.93 0.00
150_V 72_P 0.92 0.00
141_S 15_S 0.92 0.00
44_K 20_I 0.91 0.00
119_E 5_I 0.89 0.00
159_L 8_T 0.88 0.00
146_I 87_S 0.88 0.00
19_M 6_L 0.86 0.00
58_K 18_S 0.86 0.00
33_M 163_F 0.86 0.00
58_K 8_T 0.85 0.00
61_L 80_M 0.85 0.00
88_V 6_L 0.84 0.00
71_F 105_K 0.84 0.00
178_Y 115_H 0.84 0.00
49_G 37_L 0.84 0.00
92_P 16_V 0.84 0.00
108_T 93_V 0.84 0.00
58_K 11_A 0.83 0.00
90_A 135_D 0.83 0.00
163_V 181_R 0.83 0.00
21_V 65_L 0.83 0.00
72_L 50_A 0.83 0.00
203_Q 131_Q 0.82 0.00
73_N 42_L 0.82 0.00
105_F 13_L 0.82 0.00
86_L 38_L 0.81 0.00
72_L 52_A 0.81 0.00
174_S 96_L 0.81 0.00
103_S 66_I 0.81 0.00
54_F 166_A 0.81 0.00
105_F 163_F 0.81 0.00
148_Q 10_C 0.81 0.00
134_Y 119_N 0.81 0.00
58_K 41_K 0.81 0.00
10_L 131_Q 0.80 0.00
35_G 71_Q 0.80 0.00
38_N 3_V 0.80 0.00
159_L 11_A 0.80 0.00
174_S 150_N 0.79 0.00
150_V 116_M 0.79 0.00
139_Y 147_M 0.79 0.00
188_G 43_F 0.79 0.00
46_L 160_G 0.79 0.00
49_G 30_S 0.78 0.00
160_A 165_A 0.78 0.00
12_W 11_A 0.78 0.00
171_N 66_I 0.78 0.00
21_V 63_F 0.77 0.00
184_L 192_N 0.77 0.00
178_Y 53_A 0.77 0.00
20_P 192_N 0.77 0.00
148_Q 2_N 0.77 0.00
72_L 10_C 0.76 0.00
88_V 145_Y 0.76 0.00
103_S 107_T 0.76 0.00
160_A 84_G 0.75 0.00
86_L 7_D 0.75 0.00
43_D 34_D 0.75 0.00
122_L 147_M 0.75 0.00
178_Y 16_V 0.75 0.00
74_V 99_I 0.75 0.00
200_K 151_P 0.75 0.00
148_Q 153_T 0.75 0.00
77_I 58_R 0.75 0.00
87_L 157_C 0.75 0.00
46_L 107_T 0.74 0.00
103_S 40_D 0.74 0.00
70_N 34_D 0.74 0.00
160_A 99_I 0.74 0.00
186_D 4_V 0.73 0.00
89_L 174_G 0.73 0.00
70_N 68_A 0.73 0.00
19_M 120_R 0.73 0.00
159_L 113_L 0.73 0.00
183_L 62_L 0.73 0.00
51_V 164_T 0.73 0.00
162_T 112_P 0.73 0.00
12_W 13_L 0.72 0.00
35_G 50_A 0.72 0.00
180_L 141_F 0.72 0.00
77_I 94_D 0.72 0.00
178_Y 29_V 0.72 0.00
186_D 174_G 0.72 0.00
144_K 8_T 0.72 0.00
74_V 150_N 0.72 0.00
140_A 33_P 0.72 0.00
23_V 132_G 0.72 0.00
178_Y 106_M 0.72 0.00
49_G 33_P 0.71 0.00
122_L 60_R 0.71 0.00
147_A 172_F 0.71 0.00
192_T 165_A 0.71 0.00
43_D 134_E 0.71 0.00
158_A 8_T 0.71 0.00
132_T 36_V 0.71 0.00
124_E 136_G 0.71 0.00
148_Q 164_T 0.70 0.00
147_A 50_A 0.70 0.00
111_Q 80_M 0.70 0.00
151_G 80_M 0.70 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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