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SYFA - SYFB
UniProt: P08312 - P07395
Length: 1122
Sequences: 1139
Seq/Len: 1.02
I_Prob: 0.97

SYFA - Phenylalanine--tRNA ligase alpha subunit
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: SYFA
SYFB - Phenylalanine--tRNA ligase beta subunit
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: SYFB
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
3pcoBD:AC:BD:ACContact Map
1b7yB:A:A:BContact Map
2rhqB:A:A:BContact Map
3l4gBNJHDFLP:AKEIGMCO:AKEIGMCO:BNJHDFLPContact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
133_I 544_M 2.47 0.97
222_N 477_E 2.30 0.96
276_H 457_I 2.06 0.91
79_E 671_R 1.97 0.88
228_H 476_D 1.66 0.72
98_G 619_G 1.62 0.69
204_P 515_F 1.62 0.68
99_R 613_D 1.53 0.60
87_L 666_H 1.51 0.59
105_G 508_Q 1.45 0.53
133_I 531_L 1.42 0.50
87_L 645_H 1.38 0.46
221_T 477_E 1.37 0.45
87_L 646_P 1.35 0.43
90_E 645_H 1.32 0.40
92_I 615_Y 1.31 0.39
246_S 161_S 1.31 0.39
276_H 459_E 1.31 0.39
160_F 531_L 1.27 0.35
164_R 586_I 1.26 0.34
114_D 500_T 1.26 0.34
106_L 570_F 1.26 0.34
288_E 409_R 1.25 0.33
99_R 616_D 1.24 0.33
192_R 511_I 1.23 0.31
46_R 711_A 1.22 0.30
246_S 30_L 1.21 0.29
165_L 534_P 1.21 0.29
205_M 515_F 1.20 0.29
203_T 513_Y 1.16 0.25
94_V 649_S 1.16 0.25
94_V 638_A 1.16 0.25
138_H 216_Y 1.14 0.24
148_H 341_L 1.14 0.23
148_H 345_G 1.13 0.23
220_F 474_I 1.09 0.20
166_L 544_M 1.09 0.19
291_S 416_L 1.07 0.18
83_L 668_E 1.06 0.17
312_L 515_F 1.01 0.14
165_L 122_F 1.00 0.14
87_L 667_P 0.99 0.13
153_A 344_T 0.98 0.13
114_D 496_K 0.97 0.12
98_G 622_E 0.97 0.12
91_T 638_A 0.97 0.12
278_N 457_I 0.97 0.12
204_P 535_S 0.97 0.12
80_S 668_E 0.97 0.12
106_L 503_N 0.96 0.11
316_F 515_F 0.95 0.11
310_T 697_A 0.94 0.11
246_S 167_A 0.93 0.10
133_I 621_L 0.93 0.10
219_S 477_E 0.93 0.10
310_T 699_E 0.93 0.10
314_S 697_A 0.93 0.10
133_I 743_V 0.92 0.10
159_W 540_E 0.92 0.10
222_N 155_D 0.90 0.09
95_S 145_T 0.89 0.09
243_F 27_M 0.89 0.08
20_D 751_E 0.89 0.08
133_I 776_A 0.87 0.08
214_V 774_I 0.87 0.08
255_A 515_F 0.87 0.08
89_A 540_E 0.87 0.08
280_L 648_Q 0.87 0.08
118_S 496_K 0.87 0.08
272_C 515_F 0.87 0.08
110_T 509_E 0.86 0.07
204_P 177_R 0.86 0.07
92_I 614_F 0.86 0.07
116_I 652_I 0.86 0.07
220_F 466_A 0.85 0.07
115_R 240_R 0.84 0.07
169_Q 759_S 0.83 0.07
111_R 695_P 0.83 0.06
67_V 345_G 0.83 0.06
175_I 45_V 0.82 0.06
217_N 415_R 0.82 0.06
179_K 33_D 0.82 0.06
133_I 771_E 0.81 0.06
85_A 705_A 0.81 0.06
98_G 636_F 0.81 0.06
178_M 322_S 0.81 0.06
94_V 662_V 0.80 0.06
96_L 605_W 0.80 0.05
91_T 717_N 0.80 0.05
185_I 46_V 0.79 0.05
220_F 316_I 0.79 0.05
317_E 515_F 0.79 0.05
6_E 313_M 0.78 0.05
165_L 533_L 0.78 0.05
226_T 356_A 0.78 0.05
169_Q 59_A 0.78 0.05
291_S 462_V 0.78 0.05
243_F 374_E 0.77 0.05
100_R 626_D 0.77 0.05
92_I 662_V 0.76 0.04
217_N 522_Q 0.76 0.04
284_G 380_L 0.76 0.04
303_T 708_R 0.76 0.04
221_T 474_I 0.76 0.04
53_R 746_G 0.76 0.04
20_D 720_A 0.76 0.04
204_P 537_I 0.75 0.04
285_I 754_K 0.75 0.04
141_D 477_E 0.75 0.04
133_I 586_I 0.75 0.04
288_E 442_D 0.74 0.04
227_L 472_N 0.74 0.04
96_L 743_V 0.74 0.04
312_L 111_R 0.74 0.04
90_E 647_G 0.74 0.04
238_D 10_E 0.74 0.04
45_L 701_S 0.74 0.04
293_F 479_V 0.74 0.04
96_L 138_P 0.74 0.04
304_M 533_L 0.73 0.04
194_Y 511_I 0.73 0.04
271_G 29_G 0.73 0.04
246_S 160_I 0.73 0.04
227_L 291_D 0.73 0.04
194_Y 514_S 0.73 0.04
169_Q 487_T 0.73 0.04
317_E 558_Y 0.73 0.04
67_V 444_W 0.73 0.04
214_V 436_E 0.72 0.04
220_F 354_T 0.72 0.04
317_E 535_S 0.72 0.04
246_S 162_V 0.72 0.04
171_S 174_G 0.72 0.04
108_P 26_T 0.71 0.04
101_I 505_K 0.71 0.04
81_A 296_K 0.71 0.04
327_K 356_A 0.71 0.04
204_P 544_M 0.71 0.03
192_R 63_R 0.71 0.03
307_Y 618_K 0.71 0.03
237_E 749_V 0.71 0.03
119_F 85_R 0.70 0.03
272_C 369_Q 0.70 0.03
232_R 303_V 0.70 0.03
272_C 768_T 0.70 0.03
207_H 535_S 0.70 0.03
98_G 605_W 0.70 0.03
49_P 52_E 0.70 0.03
5_A 772_E 0.70 0.03
204_P 541_M 0.70 0.03
232_R 205_I 0.70 0.03
219_S 413_L 0.70 0.03
267_L 333_L 0.70 0.03
215_D 32_V 0.70 0.03
230_F 406_I 0.70 0.03
247_Y 126_G 0.69 0.03
95_S 73_R 0.69 0.03
128_A 468_V 0.69 0.03
172_G 360_Y 0.69 0.03
188_I 169_C 0.69 0.03
141_D 586_I 0.69 0.03
297_M 143_I 0.69 0.03
114_D 65_T 0.69 0.03
224_K 744_Y 0.69 0.03
234_F 406_I 0.69 0.03
246_S 353_H 0.69 0.03
117_E 28_A 0.69 0.03
306_R 37_P 0.69 0.03
271_G 163_T 0.68 0.03
215_D 465_V 0.68 0.03
129_T 574_L 0.68 0.03
325_Q 466_A 0.68 0.03
175_I 761_I 0.68 0.03
254_S 163_T 0.68 0.03
251_T 163_T 0.68 0.03
154_D 161_S 0.68 0.03
237_E 747_K 0.68 0.03
320_L 658_R 0.68 0.03
159_W 727_C 0.68 0.03
285_I 262_Q 0.68 0.03
24_L 659_I 0.68 0.03
20_D 415_R 0.68 0.03
263_N 34_G 0.68 0.03
16_S 72_D 0.67 0.03
318_N 259_E 0.67 0.03
125_F 474_I 0.67 0.03
230_F 172_I 0.67 0.03
259_V 287_L 0.67 0.03
86_R 441_K 0.67 0.03
153_A 345_G 0.67 0.03
230_F 121_S 0.67 0.03
293_F 356_A 0.67 0.03
233_N 224_I 0.67 0.03
57_G 251_D 0.67 0.03
280_L 664_V 0.67 0.03
247_Y 495_L 0.67 0.03
49_P 331_V 0.67 0.03
288_E 412_K 0.67 0.03
304_M 537_I 0.67 0.03
10_S 423_D 0.67 0.03
125_F 585_G 0.67 0.03
246_S 708_R 0.66 0.03
72_N 713_V 0.66 0.03
213_I 76_D 0.66 0.03
95_S 599_N 0.66 0.03
59_V 710_I 0.66 0.03
239_L 763_Q 0.66 0.03
98_G 624_V 0.66 0.03
220_F 136_E 0.66 0.03
179_K 216_Y 0.66 0.03
160_F 534_P 0.66 0.03
95_S 397_E 0.66 0.03
186_R 60_D 0.66 0.03
88_A 657_E 0.65 0.03
98_G 618_K 0.65 0.03
154_D 84_C 0.65 0.03
218_I 615_Y 0.65 0.03
207_H 515_F 0.65 0.02
53_R 351_G 0.65 0.02
300_E 331_V 0.65 0.02
60_I 264_M 0.65 0.02
154_D 164_P 0.65 0.02
154_D 31_E 0.65 0.02
56_A 281_A 0.65 0.02
15_I 738_V 0.65 0.02
312_L 521_Q 0.65 0.02
67_V 403_R 0.65 0.02
315_F 561_N 0.65 0.02
205_M 177_R 0.65 0.02
219_S 337_F 0.64 0.02
185_I 421_I 0.64 0.02
90_E 101_G 0.64 0.02
13_A 296_K 0.64 0.02
53_R 77_I 0.64 0.02
73_A 717_N 0.64 0.02
29_V 57_P 0.64 0.02
228_H 410_R 0.64 0.02
322_F 357_S 0.64 0.02
201_T 515_F 0.64 0.02
270_L 705_A 0.64 0.02
111_R 459_E 0.64 0.02
246_S 182_L 0.64 0.02
228_H 21_L 0.64 0.02
261_G 159_E 0.64 0.02
215_D 434_G 0.64 0.02
207_H 701_S 0.64 0.02
281_R 788_R 0.64 0.02
187_I 282_K 0.64 0.02
99_R 622_E 0.64 0.02
125_F 175_V 0.64 0.02
219_S 417_I 0.64 0.02
238_D 159_E 0.63 0.02
288_E 615_Y 0.63 0.02
95_S 421_I 0.63 0.02
47_E 224_I 0.63 0.02
92_I 149_E 0.63 0.02
11_A 372_A 0.63 0.02
173_V 266_A 0.63 0.02
197_D 515_F 0.63 0.02
205_M 541_M 0.63 0.02
136_D 499_K 0.63 0.02
4_L 540_E 0.63 0.02
255_A 535_S 0.63 0.02
315_F 548_L 0.63 0.02
27_V 705_A 0.63 0.02
127_V 155_D 0.63 0.02
246_S 175_V 0.63 0.02
23_A 684_L 0.63 0.02
76_A 715_A 0.63 0.02
285_I 258_L 0.63 0.02
196_N 544_M 0.62 0.02
72_N 326_D 0.62 0.02
9_A 139_A 0.62 0.02
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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