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HEM1 - HEM4
UniProt: P0A6X1 - P09126
Length: 664
Sequences: 460
Seq/Len: 0.69
I_Prob: 0.04

HEM1 - Glutamyl-tRNA reductase
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: HEM1
HEM4 - Uroporphyrinogen-III synthase
Paralog alert: 0.13 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: HEM4
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution.

Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
125_F 233_A 1.72 0.04
20_R 3_I 1.18 0.01
83_D 147_A 1.17 0.01
254_L 87_I 1.16 0.01
75_D 129_A 1.15 0.01
105_S 185_T 1.15 0.01
297_L 112_S 1.15 0.01
122_K 231_K 1.14 0.01
185_V 141_I 1.13 0.01
247_I 26_A 1.12 0.01
168_A 90_T 1.12 0.01
124_A 219_A 1.10 0.01
218_R 83_D 1.10 0.01
106_G 115_L 1.08 0.01
292_L 3_I 1.07 0.01
116_Q 23_G 1.06 0.01
169_A 233_A 1.06 0.01
187_L 117_Q 1.05 0.01
257_I 242_L 1.05 0.01
262_V 219_A 1.02 0.01
272_Q 94_A 1.02 0.01
133_M 198_P 1.02 0.01
286_E 3_I 1.01 0.01
252_S 242_L 1.01 0.01
407_R 137_G 1.00 0.01
279_I 217_R 1.00 0.01
417_L 211_L 1.00 0.01
257_I 34_F 0.99 0.01
327_Q 52_E 0.99 0.01
188_V 112_S 0.98 0.01
194_I 233_A 0.97 0.01
148_V 185_T 0.97 0.01
343_E 32_I 0.96 0.01
22_S 112_S 0.96 0.01
181_S 143_D 0.96 0.01
197_V 112_S 0.96 0.00
256_I 86_A 0.96 0.00
359_L 157_C 0.96 0.00
205_K 55_L 0.95 0.00
82_E 100_G 0.95 0.00
201_L 241_L 0.94 0.00
108_D 62_H 0.94 0.00
186_L 223_R 0.93 0.00
199_R 87_I 0.93 0.00
284_D 187_G 0.93 0.00
286_E 113_E 0.93 0.00
10_H 43_L 0.93 0.00
252_S 188_E 0.93 0.00
286_E 207_L 0.92 0.00
9_N 87_I 0.91 0.00
93_D 185_T 0.91 0.00
300_V 238_N 0.91 0.00
117_I 237_D 0.91 0.00
30_Q 28_H 0.91 0.00
69_L 56_L 0.91 0.00
14_P 133_R 0.90 0.00
185_V 54_D 0.90 0.00
22_S 97_T 0.90 0.00
72_W 57_F 0.90 0.00
194_I 218_L 0.90 0.00
100_L 172_M 0.89 0.00
390_H 115_L 0.89 0.00
17_L 47_L 0.89 0.00
260_G 47_L 0.89 0.00
243_A 57_F 0.89 0.00
276_L 18_R 0.88 0.00
373_A 2_S 0.88 0.00
20_R 219_A 0.88 0.00
41_V 101_Q 0.87 0.00
133_M 147_A 0.87 0.00
181_S 21_T 0.87 0.00
287_P 30_P 0.87 0.00
297_L 135_N 0.87 0.00
320_E 234_D 0.86 0.00
256_I 137_G 0.86 0.00
43_G 233_A 0.86 0.00
251_A 87_I 0.86 0.00
183_V 237_D 0.86 0.00
67_E 147_A 0.86 0.00
166_A 32_I 0.86 0.00
15_V 238_N 0.86 0.00
21_V 187_G 0.85 0.00
112_L 144_T 0.85 0.00
47_L 131_I 0.85 0.00
367_L 172_M 0.85 0.00
118_L 187_G 0.85 0.00
256_I 58_A 0.85 0.00
47_L 27_W 0.85 0.00
355_V 58_A 0.85 0.00
85_R 128_R 0.84 0.00
351_Q 96_H 0.84 0.00
205_K 30_P 0.84 0.00
230_V 137_G 0.84 0.00
300_V 243_R 0.84 0.00
335_W 193_L 0.84 0.00
254_L 77_K 0.84 0.00
57_L 57_F 0.83 0.00
277_V 32_I 0.83 0.00
284_D 185_T 0.83 0.00
135_A 233_A 0.83 0.00
372_D 13_E 0.83 0.00
69_L 64_V 0.83 0.00
171_T 236_A 0.83 0.00
11_K 141_I 0.83 0.00
187_L 215_S 0.83 0.00
198_A 134_G 0.82 0.00
390_H 149_G 0.82 0.00
367_L 221_L 0.82 0.00
106_G 136_G 0.82 0.00
405_N 107_Q 0.82 0.00
257_I 44_A 0.82 0.00
148_V 3_I 0.82 0.00
125_F 57_F 0.82 0.00
334_A 3_I 0.82 0.00
151_R 37_G 0.82 0.00
34_S 87_I 0.82 0.00
122_K 132_L 0.81 0.00
143_Q 191_Q 0.81 0.00
315_K 105_Y 0.81 0.00
327_Q 199_Q 0.81 0.00
252_S 216_E 0.81 0.00
280_A 103_I 0.81 0.00
91_H 224_E 0.81 0.00
3_L 95_L 0.81 0.00
197_V 198_P 0.81 0.00
19_E 23_G 0.81 0.00
18_R 138_R 0.80 0.00
106_G 154_F 0.80 0.00
142_F 240_A 0.80 0.00
300_V 143_D 0.79 0.00
178_E 182_V 0.79 0.00
257_I 237_D 0.79 0.00
295_A 141_I 0.79 0.00
138_L 84_Y 0.79 0.00
192_E 4_L 0.79 0.00
209_M 81_L 0.79 0.00
149_A 179_V 0.79 0.00
158_I 25_V 0.79 0.00
245_I 169_E 0.79 0.00
103_V 62_H 0.79 0.00
179_S 58_A 0.79 0.00
287_P 152_V 0.79 0.00
286_E 2_S 0.79 0.00
128_S 244_A 0.78 0.00
307_I 237_D 0.78 0.00
111_V 178_E 0.78 0.00
293_A 117_Q 0.78 0.00
289_V 117_Q 0.78 0.00
297_L 19_L 0.78 0.00
408_L 242_L 0.78 0.00
253_P 210_R 0.78 0.00
117_I 240_A 0.78 0.00
400_A 26_A 0.78 0.00
397_Q 233_A 0.77 0.00
360_T 235_N 0.77 0.00
58_S 173_R 0.77 0.00
145_S 23_G 0.77 0.00
149_A 63_A 0.77 0.00
106_G 26_A 0.77 0.00
361_A 213_V 0.77 0.00
291_K 236_A 0.77 0.00
198_A 104_L 0.77 0.00
13_A 213_V 0.77 0.00
122_K 96_H 0.77 0.00
97_V 137_G 0.77 0.00
92_Q 31_L 0.77 0.00
235_D 146_T 0.77 0.00
194_I 59_L 0.77 0.00
5_A 33_E 0.76 0.00
18_R 150_A 0.76 0.00
10_H 150_A 0.76 0.00
205_K 241_L 0.76 0.00
166_A 197_I 0.76 0.00
220_Q 56_L 0.76 0.00
35_L 174_W 0.76 0.00
18_R 6_T 0.76 0.00
326_A 237_D 0.76 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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