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XDHA - XDHB
UniProt: Q46799 - Q46800
Length: 1044
Sequences: 1609
Seq/Len: 1.56
I_Prob: 0.60

XDHA - Xanthine dehydrogenase molybdenum-binding subunit
Paralog alert: 0.62 [within 20: 0.24] - ratio of genomes with paralogs
Cluster includes: XDHA XDHD YAGR
XDHB - Xanthine dehydrogenase FAD-binding subunit
Paralog alert: 0.56 [within 20: 0.15] - ratio of genomes with paralogs
Cluster includes: XDHB YAGS YGFM
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
1rm6AD:BEContact Map
1t3qBE:CFContact Map
1ffvBE:CFContact Map
1n62BE:CFContact Map
3hrdAE:BF:CGContact Map
3nvzCL:BKContact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
615_D 278_K 1.68 0.60
617_A 274_T 1.67 0.59
679_K 193_D 1.41 0.37
617_A 278_K 1.19 0.21
617_A 277_K 1.13 0.17
740_K 264_S 1.00 0.10
744_E 266_E 0.98 0.10
497_V 6_S 0.97 0.10
226_V 105_I 0.95 0.09
291_D 66_D 0.94 0.08
743_Y 270_H 0.93 0.08
651_M 268_R 0.92 0.08
133_A 21_A 0.91 0.07
620_K 184_F 0.91 0.07
100_V 14_A 0.90 0.07
48_R 50_V 0.89 0.07
686_L 186_Y 0.87 0.06
115_A 73_S 0.85 0.06
41_S 140_P 0.84 0.06
164_D 137_I 0.83 0.05
163_I 69_L 0.83 0.05
681_P 260_S 0.83 0.05
436_V 115_I 0.83 0.05
459_M 74_A 0.82 0.05
277_R 102_G 0.81 0.05
164_D 249_E 0.81 0.05
620_K 186_Y 0.81 0.05
493_P 266_E 0.79 0.04
49_S 232_Q 0.79 0.04
534_L 12_T 0.78 0.04
8_K 114_N 0.78 0.04
480_T 107_N 0.78 0.04
603_P 264_S 0.77 0.04
724_V 19_L 0.77 0.04
289_N 71_I 0.75 0.04
277_R 123_D 0.74 0.03
225_C 169_F 0.73 0.03
365_L 29_L 0.73 0.03
682_T 189_R 0.73 0.03
516_A 157_K 0.73 0.03
93_V 247_I 0.72 0.03
55_A 171_F 0.72 0.03
32_S 211_S 0.72 0.03
4_D 34_D 0.72 0.03
379_I 112_G 0.71 0.03
331_A 71_I 0.71 0.03
106_R 169_F 0.70 0.03
293_T 147_P 0.69 0.03
712_P 34_D 0.69 0.03
679_K 77_F 0.69 0.03
294_L 224_P 0.69 0.03
228_V 74_A 0.69 0.03
15_Y 160_L 0.69 0.03
165_A 65_E 0.69 0.03
119_S 204_R 0.69 0.03
13_A 114_N 0.68 0.03
43_N 215_L 0.68 0.03
236_G 183_H 0.68 0.03
95_H 279_V 0.68 0.03
37_G 130_I 0.68 0.03
412_K 211_S 0.68 0.03
42_I 240_N 0.68 0.03
277_R 185_K 0.68 0.03
95_H 190_D 0.68 0.03
739_P 188_M 0.67 0.02
291_D 169_F 0.67 0.02
630_H 117_N 0.67 0.02
277_R 33_T 0.67 0.02
495_S 132_D 0.67 0.02
259_I 212_E 0.67 0.02
49_S 88_R 0.67 0.02
495_S 145_F 0.66 0.02
302_L 215_L 0.66 0.02
725_K 105_I 0.66 0.02
142_I 76_T 0.66 0.02
527_L 109_A 0.66 0.02
724_V 280_I 0.66 0.02
46_Q 241_L 0.65 0.02
298_S 147_P 0.65 0.02
630_H 34_D 0.65 0.02
104_V 108_V 0.65 0.02
486_V 109_A 0.65 0.02
480_T 51_D 0.65 0.02
186_S 77_F 0.65 0.02
43_N 15_D 0.65 0.02
352_Y 121_S 0.64 0.02
682_T 109_A 0.64 0.02
540_A 161_E 0.64 0.02
551_M 161_E 0.64 0.02
56_I 283_A 0.64 0.02
509_P 224_P 0.64 0.02
210_I 268_R 0.64 0.02
743_Y 271_L 0.64 0.02
5_A 33_T 0.64 0.02
525_P 132_D 0.63 0.02
592_A 88_R 0.63 0.02
105_A 94_C 0.63 0.02
553_L 230_A 0.63 0.02
157_G 200_A 0.63 0.02
473_E 33_T 0.63 0.02
412_K 146_V 0.63 0.02
497_V 253_Q 0.63 0.02
35_A 243_T 0.62 0.02
669_V 214_R 0.62 0.02
473_E 114_N 0.62 0.02
491_G 67_G 0.62 0.02
181_H 218_G 0.62 0.02
645_V 134_K 0.62 0.02
287_G 102_G 0.62 0.02
365_L 185_K 0.62 0.02
372_L 131_Y 0.62 0.02
679_K 189_R 0.62 0.02
167_D 62_T 0.61 0.02
685_D 193_D 0.61 0.02
222_P 147_P 0.61 0.02
357_V 122_A 0.61 0.02
93_V 256_A 0.61 0.02
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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