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6PGD - 6-phosphogluconate dehydrogenase, decarboxylating
UniProt: P00350 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10411
Length: 468 (467)
Sequences: 944
Seq/Len: 2.02

6PGD
Paralog alert: 0.05 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
320_K 406_D 4.415 1.00
453_Y 464_T 3.866 1.00
57_V 90_Y 3.567 1.00
85_D 114_E 3.551 1.00
380_E 390_A 3.405 1.00
5_Q 65_E 3.064 1.00
204_L 210_L 3.039 1.00
212_N 248_Y 3.001 1.00
319_E 322_R 2.929 1.00
202_S 206_G 2.871 1.00
24_S 135_L 2.855 1.00
226_E 322_R 2.767 1.00
109_I 176_D 2.74 1.00
204_L 321_V 2.737 1.00
213_E 242_K 2.653 1.00
30_S 63_S 2.614 1.00
210_L 218_T 2.613 1.00
4_Q 30_S 2.602 1.00
340_L 351_L 2.543 1.00
105_F 347_Y 2.494 1.00
43_I 53_P 2.439 1.00
214_E 314_K 2.408 1.00
40_E 55_Y 2.394 1.00
125_T 140_I 2.374 1.00
153_A 157_T 2.373 1.00
411_A 418_V 2.32 1.00
198_A 441_I 2.307 1.00
351_L 356_I 2.305 1.00
215_L 239_F 2.303 1.00
216_A 240_T 2.301 1.00
123_I 152_V 2.245 1.00
66_T 92_D 2.222 1.00
78_A 82_A 2.218 1.00
303_L 428_Y 2.208 1.00
217_Q 240_T 2.2 1.00
58_K 62_E 2.2 1.00
211_T 214_E 2.185 1.00
11_M 42_V 2.122 0.99
289_I 430_S 2.114 0.99
210_L 318_I 2.077 0.99
6_I 22_I 2.071 0.99
237_D 447_Y 2.041 0.99
163_A 362_A 2.04 0.99
7_G 60_F 2.039 0.99
61_V 90_Y 2.015 0.99
36_R 40_E 2.008 0.99
249_L 253_I 1.995 0.99
220_T 240_T 1.976 0.99
27_Y 158_K 1.953 0.99
375_T 379_A 1.937 0.99
23_E 49_K 1.936 0.99
352_N 355_E 1.928 0.99
175_A 344_S 1.917 0.99
56_T 59_E 1.91 0.98
328_G 421_F 1.897 0.98
238_I 443_A 1.892 0.98
204_L 215_L 1.886 0.98
192_G 332_S 1.869 0.98
301_K 434_A 1.859 0.98
88_K 120_F 1.858 0.98
409_A 413_Q 1.845 0.98
212_N 251_D 1.83 0.98
114_E 117_A 1.79 0.97
207_G 414_N 1.769 0.97
31_I 42_V 1.767 0.97
298_A 385_A 1.765 0.97
327_L 404_L 1.738 0.97
221_E 224_N 1.722 0.97
80_T 103_T 1.715 0.96
12_A 75_K 1.712 0.96
146_K 150_E 1.699 0.96
408_V 412_V 1.693 0.96
40_E 44_A 1.677 0.96
218_T 318_I 1.668 0.96
293_K 297_V 1.661 0.96
200_A 421_F 1.65 0.95
221_E 322_R 1.643 0.95
422_S 426_A 1.632 0.95
203_L 317_F 1.612 0.95
203_L 321_V 1.611 0.94
69_R 151_L 1.605 0.94
96_I 151_L 1.603 0.94
409_A 412_V 1.597 0.94
11_M 31_I 1.582 0.94
221_E 315_A 1.562 0.93
395_Q 399_D 1.545 0.93
454_K 461_V 1.541 0.93
204_L 208_L 1.511 0.92
244_E 458_K 1.511 0.92
19_A 31_I 1.511 0.92
405_R 429_D 1.506 0.91
193_D 329_K 1.492 0.91
205_K 212_N 1.488 0.91
73_M 159_I 1.487 0.91
321_V 421_F 1.485 0.91
208_L 321_V 1.481 0.91
88_K 118_E 1.478 0.90
113_R 117_A 1.475 0.90
215_L 321_V 1.462 0.90
150_E 153_A 1.45 0.89
233_D 367_R 1.449 0.89
323_R 403_A 1.449 0.89
454_K 459_E 1.44 0.89
171_T 355_E 1.438 0.89
84_I 97_I 1.407 0.87
380_E 391_P 1.404 0.87
410_Y 413_Q 1.391 0.86
158_K 162_V 1.358 0.85
75_K 78_A 1.356 0.85
36_R 55_Y 1.342 0.84
305_G 432_R 1.338 0.83
295_Q 431_Y 1.333 0.83
112_N 116_S 1.324 0.83
70_I 97_I 1.322 0.82
354_G 375_T 1.305 0.81
300_S 434_A 1.304 0.81
9_V 32_F 1.298 0.81
46_N 135_L 1.296 0.81
25_R 158_K 1.289 0.80
373_K 376_D 1.289 0.80
319_E 323_R 1.288 0.80
58_K 90_Y 1.287 0.80
216_A 239_F 1.282 0.80
408_V 422_S 1.277 0.79
256_E 454_K 1.276 0.79
295_Q 386_N 1.274 0.79
61_V 91_L 1.26 0.78
54_Y 59_E 1.258 0.78
200_A 321_V 1.256 0.78
84_I 115_L 1.252 0.77
22_I 71_L 1.251 0.77
37_E 41_E 1.25 0.77
394_K 398_D 1.245 0.77
132_E 136_K 1.239 0.76
323_R 400_Y 1.23 0.76
23_E 50_K 1.228 0.75
71_L 156_L 1.227 0.75
323_R 399_D 1.226 0.75
264_K 272_D 1.225 0.75
103_T 107_D 1.225 0.75
30_S 54_Y 1.222 0.75
354_G 379_A 1.218 0.75
140_I 160_A 1.215 0.74
70_I 91_L 1.208 0.74
316_E 406_D 1.208 0.74
54_Y 63_S 1.199 0.73
88_K 114_E 1.199 0.73
167_E 358_K 1.196 0.73
116_S 145_Q 1.195 0.73
204_L 218_T 1.195 0.73
435_V 456_I 1.192 0.72
225_G 322_R 1.19 0.72
173_I 178_A 1.189 0.72
207_G 416_I 1.178 0.71
303_L 432_R 1.176 0.71
197_I 325_L 1.17 0.70
247_N 252_V 1.163 0.70
104_F 268_Q 1.161 0.70
415_G 432_R 1.16 0.69
418_V 422_S 1.157 0.69
6_I 71_L 1.147 0.68
412_V 426_A 1.145 0.68
196_L 420_T 1.14 0.68
75_K 79_G 1.136 0.67
316_E 320_K 1.135 0.67
338_S 427_Y 1.134 0.67
23_E 135_L 1.134 0.67
109_I 113_R 1.132 0.67
384_I 390_A 1.129 0.66
342_A 345_E 1.126 0.66
124_G 143_G 1.124 0.66
73_M 140_I 1.121 0.66
98_I 152_V 1.118 0.65
226_E 319_E 1.11 0.64
28_T 50_K 1.108 0.64
22_I 155_I 1.107 0.64
406_D 413_Q 1.106 0.64
4_Q 52_V 1.102 0.64
79_G 82_A 1.098 0.63
282_E 285_F 1.097 0.63
116_S 147_E 1.097 0.63
342_A 346_E 1.096 0.63
306_P 401_Q 1.095 0.63
223_N 233_D 1.092 0.63
12_A 34_R 1.084 0.62
220_T 224_N 1.082 0.62
245_D 252_V 1.081 0.61
30_S 60_F 1.078 0.61
205_K 251_D 1.071 0.60
242_K 248_Y 1.07 0.60
415_G 429_D 1.068 0.60
249_L 252_V 1.067 0.60
455_R 462_F 1.063 0.60
83_A 86_S 1.058 0.59
429_D 432_R 1.058 0.59
171_T 359_I 1.057 0.59
305_G 401_Q 1.054 0.59
326_Y 396_I 1.047 0.58
344_S 350_D 1.046 0.58
24_S 136_K 1.044 0.57
210_L 314_K 1.043 0.57
401_Q 432_R 1.041 0.57
12_A 33_N 1.037 0.57
344_S 353_Y 1.032 0.56
405_R 415_G 1.032 0.56
181_Y 269_S 1.031 0.56
457_D 462_F 1.027 0.56
279_L 331_V 1.025 0.55
120_F 147_E 1.023 0.55
121_N 147_E 1.022 0.55
327_L 400_Y 1.022 0.55
317_F 410_Y 1.02 0.55
298_A 301_K 1.015 0.54
185_V 339_Q 1.011 0.54
18_L 159_I 1.008 0.53
173_I 359_I 1.003 0.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2zydA211000.315Contact Map0.748
2p4qA10.99571000.316Contact Map0.7
1pgjA20.98721000.328Contact Map0.638
2iz1A311000.33Contact Map0.778
4gwgA111000.34Contact Map0.7
4e21A20.69231000.77Contact Map0.69
3pefA80.60471000.837Contact Map0.543
3pduA80.60261000.841Contact Map0.448
3dojA10.61541000.841Contact Map0.528
3ckyA40.62821000.844Contact Map0.529

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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