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AAT - Aspartate aminotransferase
UniProt: P00509 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10096
Length: 396 (383)
Sequences: 19018
Seq/Len: 49.66

AAT
Paralog alert: 0.93 [within 20: 0.25] - ratio of genomes with paralogs
Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
163_I 203_E 3.131 1.00
319_Q 323_Q 2.994 1.00
122_R 143_E 2.961 1.00
54_Q 58_E 2.954 1.00
191_L 195_Q 2.92 1.00
320_R 382_P 2.839 1.00
100_T 106_A 2.813 1.00
365_F 394_A 2.77 1.00
83_F 89_L 2.718 1.00
324_L 386_A 2.671 1.00
47_T 51_K 2.595 1.00
77_C 299_S 2.554 1.00
339_S 352_G 2.524 1.00
360_R 364_E 2.523 1.00
121_K 173_D 2.521 1.00
117_N 142_L 2.485 1.00
387_P 391_A 2.453 1.00
73_E 295_A 2.263 1.00
195_Q 199_Q 2.2 1.00
190_T 193_Q 2.188 1.00
255_V 294_V 2.155 1.00
51_K 55_Y 2.128 1.00
76_R 80_E 2.084 1.00
387_P 390_E 2.074 1.00
328_T 389_C 2.062 1.00
76_R 92_D 2.02 1.00
260_L 272_F 1.996 1.00
108_R 112_D 1.979 1.00
381_T 384_N 1.976 1.00
160_D 196_T 1.934 1.00
328_T 331_E 1.929 1.00
323_Q 327_N 1.924 1.00
122_R 145_R 1.921 1.00
201_S 208_P 1.916 1.00
192_E 195_Q 1.913 1.00
327_N 331_E 1.912 1.00
174_V 209_L 1.911 1.00
326_V 330_Q 1.902 1.00
72_P 76_R 1.856 1.00
137_F 142_L 1.853 1.00
326_V 342_I 1.833 1.00
209_L 241_A 1.828 1.00
163_I 196_T 1.815 1.00
158_D 161_A 1.802 1.00
127_N 146_E 1.795 1.00
77_C 80_E 1.791 1.00
213_A 243_S 1.779 1.00
31_L 388_L 1.771 1.00
103_G 241_A 1.77 1.00
156_T 193_Q 1.759 1.00
324_L 382_P 1.746 1.00
80_E 299_S 1.735 1.00
196_T 199_Q 1.73 1.00
110_A 209_L 1.726 1.00
205_G 237_E 1.724 1.00
161_A 165_S 1.678 1.00
79_Q 92_D 1.673 1.00
330_Q 340_F 1.667 1.00
324_L 328_T 1.656 1.00
55_Y 296_T 1.635 1.00
110_A 239_I 1.633 1.00
161_A 164_N 1.628 1.00
78_T 257_A 1.608 1.00
312_T 316_Q 1.603 1.00
50_K 54_Q 1.577 1.00
93_K 265_S 1.567 1.00
123_V 137_F 1.56 1.00
199_Q 203_E 1.552 1.00
122_R 172_G 1.544 1.00
150_Y 193_Q 1.542 1.00
134_K 138_N 1.539 1.00
73_E 299_S 1.531 1.00
258_C 275_M 1.525 1.00
287_P 290_G 1.515 1.00
84_G 308_E 1.508 1.00
325_F 349_S 1.505 1.00
122_R 171_A 1.491 1.00
51_K 54_Q 1.491 1.00
78_T 99_Q 1.485 1.00
201_S 206_W 1.483 1.00
77_C 295_A 1.475 1.00
199_Q 202_V 1.474 1.00
111_A 137_F 1.467 1.00
359_L 363_E 1.458 1.00
52_A 296_T 1.443 1.00
111_A 176_L 1.441 1.00
90_I 259_T 1.44 1.00
326_V 349_S 1.437 1.00
122_R 167_N 1.436 1.00
163_I 204_K 1.43 1.00
166_L 200_L 1.43 1.00
390_E 394_A 1.429 1.00
312_T 315_R 1.428 1.00
71_I 292_S 1.425 1.00
328_T 390_E 1.425 1.00
159_F 200_L 1.418 1.00
177_F 197_L 1.417 1.00
328_T 393_V 1.411 1.00
111_A 117_N 1.388 0.99
163_I 167_N 1.378 0.99
326_V 340_F 1.371 0.99
80_E 84_G 1.371 0.99
328_T 386_A 1.368 0.99
127_N 148_A 1.367 0.99
382_P 386_A 1.362 0.99
328_T 332_K 1.34 0.99
75_G 79_Q 1.332 0.99
365_F 391_A 1.33 0.99
82_L 259_T 1.316 0.99
79_Q 95_A 1.313 0.99
123_V 174_V 1.308 0.99
191_L 226_E 1.307 0.99
193_Q 196_T 1.301 0.99
175_V 206_W 1.301 0.99
239_I 258_C 1.3 0.99
330_Q 342_I 1.3 0.99
148_A 161_A 1.294 0.99
244_Y 294_V 1.282 0.99
47_T 50_K 1.281 0.99
69_D 276_K 1.276 0.99
200_L 204_K 1.275 0.99
386_A 390_E 1.274 0.99
114_L 207_L 1.268 0.99
239_I 260_L 1.266 0.99
195_Q 234_M 1.265 0.99
150_Y 153_E 1.262 0.99
316_Q 319_Q 1.261 0.99
69_D 75_G 1.255 0.99
125_V 144_V 1.251 0.99
105_G 279_I 1.251 0.99
159_F 196_T 1.248 0.99
78_T 95_A 1.245 0.98
274_Q 277_A 1.237 0.98
117_N 123_V 1.237 0.98
72_P 92_D 1.236 0.98
112_D 140_A 1.23 0.98
200_L 206_W 1.226 0.98
134_K 146_E 1.224 0.98
358_V 369_A 1.223 0.98
53_E 293_V 1.222 0.98
164_N 168_E 1.22 0.98
325_F 389_C 1.22 0.98
322_R 326_V 1.21 0.98
98_A 272_F 1.208 0.98
331_E 393_V 1.207 0.98
82_L 257_A 1.198 0.98
192_E 196_T 1.194 0.98
91_N 265_S 1.189 0.98
91_N 94_R 1.189 0.98
26_P 366_G 1.182 0.98
160_D 164_N 1.177 0.98
242_S 257_A 1.175 0.98
53_E 57_L 1.174 0.98
317_R 320_R 1.171 0.98
296_T 299_S 1.171 0.98
327_N 330_Q 1.168 0.97
50_K 58_E 1.166 0.97
301_D 309_Q 1.165 0.97
220_G 344_Q 1.161 0.97
295_A 299_S 1.161 0.97
323_Q 342_I 1.154 0.97
114_L 174_V 1.152 0.97
74_F 99_Q 1.151 0.97
163_I 200_L 1.148 0.97
55_Y 59_N 1.147 0.97
191_L 231_F 1.146 0.97
73_E 292_S 1.145 0.97
273_S 277_A 1.144 0.97
94_R 265_S 1.135 0.97
150_Y 158_D 1.129 0.97
375_V 388_L 1.128 0.97
198_A 208_P 1.128 0.97
113_F 278_A 1.121 0.97
119_S 141_G 1.116 0.96
101_P 105_G 1.115 0.96
124_W 172_G 1.107 0.96
316_Q 320_R 1.099 0.96
207_L 239_I 1.084 0.96
325_F 328_T 1.083 0.96
350_F 372_S 1.083 0.96
279_I 283_Y 1.082 0.96
79_Q 91_N 1.078 0.95
202_V 235_H 1.076 0.95
351_S 375_V 1.075 0.95
332_K 393_V 1.069 0.95
322_R 377_V 1.068 0.95
101_P 287_P 1.068 0.95
325_F 385_M 1.067 0.95
317_R 382_P 1.067 0.95
113_F 275_M 1.062 0.95
166_L 206_W 1.058 0.95
309_Q 313_D 1.057 0.95
137_F 144_V 1.055 0.95
191_L 230_A 1.052 0.95
106_A 241_A 1.042 0.94
361_L 392_I 1.04 0.94
356_E 360_R 1.038 0.94
19_L 363_E 1.036 0.94
124_W 147_Y 1.035 0.94
118_T 121_K 1.035 0.94
198_A 238_L 1.03 0.94
73_E 76_R 1.028 0.94
103_G 243_S 1.026 0.94
255_V 286_P 1.026 0.94
71_I 295_A 1.014 0.93
109_V 279_I 1.01 0.93
338_F 351_S 1.01 0.93
296_T 300_N 1.007 0.93
265_S 270_R 1.006 0.93
129_S 178_H 1.005 0.93
356_E 359_L 1 0.92
317_R 321_M 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f4eA20.99241000.252Contact Map0.548
7aatA20.99241000.264Contact Map0.574
4h51A20.96721000.267Contact Map0.566
2q7wA10.99241000.271Contact Map0.56
4eu1A20.96971000.271Contact Map0.504
1ajsA10.98741000.278Contact Map0.562
3fslA60.99241000.281Contact Map0.589
1yaaA40.98231000.281Contact Map0.588
2ay1A20.98481000.283Contact Map0.569
3k7yA10.97731000.288Contact Map0.522

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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