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AMPC - Beta-lactamase
UniProt: P00811 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10040
Length: 377 (325)
Sequences: 4501
Seq/Len: 13.85

AMPC
Paralog alert: 0.65 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: AMPC AMPH YFEW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
184_L 192_T 4.279 1.00
96_R 193_R 3.709 1.00
191_Q 196_Q 3.623 1.00
203_T 241_S 3.612 1.00
102_S 123_L 3.598 1.00
51_Q 349_E 3.521 1.00
100_K 103_D 3.496 1.00
89_L 189_A 3.476 1.00
103_D 107_K 3.466 1.00
92_D 189_A 3.09 1.00
92_D 193_R 3.028 1.00
178_A 189_A 2.893 1.00
74_T 216_A 2.878 1.00
182_S 189_A 2.805 1.00
70_V 76_F 2.788 1.00
103_D 108_Y 2.736 1.00
189_A 193_R 2.622 1.00
78_L 241_S 2.535 1.00
185_S 188_Q 2.464 1.00
47_A 247_A 2.447 1.00
58_T 72_Q 2.434 1.00
62_A 68_Q 2.378 1.00
95_A 260_N 2.372 1.00
111_E 180_K 2.262 1.00
200_L 203_T 2.169 1.00
56_Y 59_W 2.143 1.00
143_S 146_D 2.122 1.00
84_T 249_W 2.121 1.00
88_V 249_W 2.101 1.00
90_G 174_F 2.09 1.00
61_Y 67_K 2.084 1.00
29_H 59_W 2.049 1.00
176_A 179_V 2.029 1.00
104_P 107_K 2.026 1.00
63_D 66_K 2.018 1.00
176_A 180_K 1.987 1.00
250_V 351_G 1.957 1.00
130_A 133_L 1.924 1.00
184_L 189_A 1.918 1.00
95_A 263_T 1.893 1.00
121_T 124_H 1.857 1.00
130_A 170_S 1.85 1.00
93_A 178_A 1.846 1.00
90_G 99_I 1.833 1.00
92_D 96_R 1.794 1.00
175_G 235_E 1.788 1.00
190_M 195_F 1.787 1.00
61_Y 66_K 1.767 1.00
122_L 177_L 1.762 1.00
260_N 263_T 1.736 1.00
90_G 178_A 1.735 1.00
202_H 214_N 1.725 1.00
43_G 76_F 1.72 1.00
195_F 200_L 1.717 1.00
45_A 243_I 1.717 1.00
192_T 196_Q 1.697 1.00
250_V 342_V 1.679 1.00
33_T 37_E 1.677 1.00
218_G 338_F 1.659 1.00
186_F 190_M 1.659 1.00
47_A 353_V 1.648 1.00
45_A 76_F 1.647 1.00
89_L 190_M 1.625 1.00
124_H 161_G 1.596 1.00
184_L 193_R 1.589 1.00
81_V 342_V 1.568 1.00
45_A 58_T 1.567 1.00
73_Q 244_E 1.567 1.00
45_A 70_V 1.564 1.00
195_F 239_V 1.545 1.00
49_I 351_G 1.544 1.00
90_G 126_A 1.535 1.00
124_H 129_T 1.518 1.00
49_I 247_A 1.515 1.00
89_L 178_A 1.504 1.00
327_S 347_E 1.502 1.00
72_Q 244_E 1.496 1.00
93_A 182_S 1.474 1.00
87_G 126_A 1.463 1.00
80_S 83_K 1.448 1.00
188_Q 192_T 1.424 1.00
284_G 289_M 1.414 1.00
43_G 70_V 1.409 1.00
168_N 236_A 1.394 0.99
177_L 181_P 1.394 0.99
57_F 244_E 1.386 0.99
186_F 235_E 1.385 0.99
251_Q 254_L 1.378 0.99
79_G 335_T 1.376 0.99
89_L 182_S 1.375 0.99
200_L 245_D 1.369 0.99
94_I 99_I 1.365 0.99
70_V 74_T 1.36 0.99
205_I 239_V 1.358 0.99
47_A 243_I 1.351 0.99
123_L 285_L 1.343 0.99
50_Y 350_L 1.341 0.99
103_D 122_L 1.34 0.99
98_E 181_P 1.338 0.99
252_S 257_L 1.322 0.99
145_S 149_R 1.315 0.99
49_I 54_P 1.314 0.99
243_I 355_L 1.314 0.99
87_G 171_I 1.302 0.99
184_L 188_Q 1.301 0.99
195_F 203_T 1.3 0.99
71_T 74_T 1.292 0.99
91_G 101_L 1.292 0.99
85_F 239_V 1.286 0.99
47_A 54_P 1.276 0.99
94_I 101_L 1.266 0.99
32_I 46_V 1.263 0.99
254_L 344_F 1.242 0.98
46_V 354_M 1.242 0.98
99_I 181_P 1.241 0.98
83_K 166_Y 1.233 0.98
246_M 355_L 1.221 0.98
345_I 348_K 1.205 0.98
246_M 353_V 1.202 0.98
203_T 245_D 1.198 0.98
124_H 127_T 1.192 0.98
344_F 351_G 1.191 0.98
119_G 159_A 1.185 0.98
58_T 70_V 1.181 0.98
158_W 163_Q 1.18 0.98
100_K 108_Y 1.167 0.97
261_E 265_Q 1.165 0.97
62_A 74_T 1.16 0.97
91_G 94_I 1.143 0.97
85_F 200_L 1.127 0.97
29_H 56_Y 1.125 0.97
167_A 170_S 1.124 0.97
75_L 214_N 1.123 0.97
334_A 339_G 1.109 0.96
85_F 249_W 1.101 0.96
129_T 161_G 1.1 0.96
86_T 186_F 1.09 0.96
87_G 286_G 1.086 0.96
148_L 176_A 1.083 0.96
93_A 96_R 1.081 0.95
36_I 59_W 1.079 0.95
63_D 217_W 1.078 0.95
159_A 162_T 1.072 0.95
171_I 174_F 1.071 0.95
182_S 185_S 1.067 0.95
199_K 248_R 1.064 0.95
64_I 219_Y 1.059 0.95
81_V 246_M 1.047 0.94
86_T 175_G 1.046 0.94
29_H 33_T 1.046 0.94
82_S 239_V 1.043 0.94
77_E 335_T 1.043 0.94
75_L 240_K 1.04 0.94
104_P 119_G 1.028 0.94
92_D 194_V 1.026 0.94
266_Q 269_Q 1.017 0.93
175_G 186_F 1.011 0.93
43_G 357_N 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ffyA20.94961000.17Contact Map0.798
2qz6A10.94161000.192Contact Map0.758
2wzxA10.95231000.202Contact Map0.745
1zkjA10.94431000.206Contact Map0.723
2qmiA80.85411000.247Contact Map0.885
1ei5A10.83821000.251Contact Map0.684
4gdnA40.871000.251Contact Map0.887
4e6wA30.83551000.254Contact Map0.798
4ivkA10.92311000.267Contact Map0.835
2drwA60.84881000.268Contact Map0.849

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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