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CYNS - Cyanate hydratase
UniProt: P00816 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10175
Length: 156 (152)
Sequences: 224
Seq/Len: 1.47

CYNS
Paralog alert: 0.07 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
55_A 59_R 2.593 1.00
40_E 115_K 2.45 1.00
31_E 34_D 1.956 0.98
25_K 66_D 1.953 0.97
18_I 47_L 1.894 0.97
89_P 98_Y 1.853 0.96
29_F 115_K 1.617 0.91
131_K 145_T 1.557 0.88
46_A 53_L 1.522 0.87
133_V 147_D 1.493 0.85
29_F 48_L 1.475 0.84
46_A 52_A 1.474 0.84
20_L 24_K 1.459 0.84
45_A 147_D 1.416 0.81
35_G 64_K 1.404 0.80
123_A 126_F 1.403 0.80
81_R 143_V 1.402 0.80
46_A 61_V 1.4 0.80
61_V 113_H 1.378 0.78
85_D 88_I 1.377 0.78
38_L 61_V 1.375 0.78
16_D 20_L 1.374 0.78
82_G 89_P 1.353 0.77
50_Q 82_G 1.349 0.76
97_F 108_L 1.346 0.76
108_L 130_V 1.334 0.75
30_A 34_D 1.333 0.75
32_I 64_K 1.332 0.75
134_A 140_E 1.329 0.75
23_A 28_S 1.324 0.75
62_G 72_I 1.295 0.72
55_A 63_A 1.295 0.72
58_A 76_Q 1.295 0.72
18_I 29_F 1.281 0.71
91_D 113_H 1.279 0.71
110_A 144_I 1.267 0.70
100_M 135_D 1.267 0.70
33_A 43_V 1.251 0.68
59_R 69_E 1.247 0.68
30_A 144_I 1.243 0.68
45_A 51_Q 1.238 0.67
125_N 141_R 1.237 0.67
44_T 111_L 1.232 0.67
112_V 142_A 1.232 0.67
84_I 153_T 1.185 0.62
48_L 111_L 1.18 0.62
90_T 98_Y 1.178 0.62
66_D 76_Q 1.162 0.60
55_A 70_D 1.16 0.60
143_V 146_L 1.151 0.59
89_P 102_Q 1.124 0.56
10_I 56_D 1.123 0.56
100_M 106_T 1.106 0.54
42_F 103_V 1.098 0.54
144_I 153_T 1.096 0.53
70_D 73_L 1.094 0.53
108_L 128_L 1.085 0.52
81_R 93_T 1.084 0.52
38_L 132_K 1.083 0.52
30_A 115_K 1.081 0.52
35_G 63_A 1.065 0.50
140_E 153_T 1.065 0.50
26_D 142_A 1.063 0.50
44_T 48_L 1.061 0.50
142_A 156_F 1.061 0.50
136_P 150_Y 1.055 0.49
16_D 31_E 1.051 0.49
7_N 140_E 1.05 0.49
10_I 16_D 1.046 0.48
40_E 130_V 1.045 0.48
70_D 74_L 1.039 0.47
103_V 112_V 1.038 0.47
49_G 62_G 1.038 0.47
21_S 94_M 1.037 0.47
102_Q 126_F 1.035 0.47
10_I 13_D 1.033 0.47
132_K 150_Y 1.031 0.47
60_L 63_A 1.029 0.46
53_L 111_L 1.027 0.46
45_A 88_I 1.016 0.45
55_A 76_Q 1.006 0.44
20_L 31_E 1.001 0.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1dw9A1011000.142Contact Map0.396
2kpjA10.602697.50.888Contact Map0.415
1y7yA20.474497.30.89Contact Map0.609
2r1jL20.435997.10.894Contact Map0.502
2ictA10.602697.10.895Contact Map0.386
1adrA10.487297.10.895Contact Map0.519
3f6wA50.5064970.896Contact Map0.445
2ewtA10.4423970.896Contact Map0.459
4ghjA20.596.90.897Contact Map0.504
2k9qA20.493696.90.897Contact Map0.331

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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