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AROH - Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive
UniProt: P00887 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10080
Length: 348 (347)
Sequences: 1129
Seq/Len: 3.25

AROH
Paralog alert: 0.71 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: AROF AROG AROH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
241_H 244_D 5.624 1.00
81_Q 338_E 4.392 1.00
111_D 120_H 4.364 1.00
70_E 304_L 4.111 1.00
44_K 49_E 3.898 1.00
318_T 321_Q 3.395 1.00
305_R 321_Q 3.341 1.00
24_R 123_E 3.129 1.00
80_N 83_Q 3.097 1.00
306_E 329_G 3.04 1.00
328_L 336_L 2.972 1.00
305_R 318_T 2.941 1.00
57_I 333_T 2.932 1.00
82_Y 338_E 2.854 1.00
76_Q 80_N 2.818 1.00
85_R 345_D 2.798 1.00
329_G 332_D 2.741 1.00
275_R 306_E 2.713 1.00
112_L 323_I 2.713 1.00
127_K 131_Q 2.682 1.00
282_E 339_K 2.627 1.00
68_A 128_L 2.492 1.00
245_I 263_V 2.452 1.00
274_H 326_P 2.391 1.00
45_I 87_E 2.386 1.00
41_R 87_E 2.256 1.00
253_H 259_E 2.212 1.00
283_D 286_Q 2.195 1.00
37_D 41_R 2.188 1.00
311_I 323_I 2.156 1.00
117_R 120_H 2.095 1.00
276_R 279_E 2.068 1.00
25_Y 130_L 2.048 1.00
70_E 319_Y 2.019 1.00
42_I 89_V 2.001 1.00
111_D 117_R 1.965 1.00
128_L 132_V 1.933 1.00
274_H 306_E 1.917 1.00
79_R 87_E 1.857 0.99
47_N 227_Y 1.809 0.99
191_N 194_I 1.787 0.99
55_V 298_I 1.756 0.99
265_F 281_C 1.751 0.99
249_C 292_S 1.747 0.99
33_T 37_D 1.743 0.99
66_T 73_T 1.721 0.99
158_W 229_H 1.688 0.99
73_T 135_L 1.682 0.98
249_C 294_A 1.68 0.98
263_V 284_I 1.673 0.98
340_L 344_V 1.646 0.98
275_R 332_D 1.611 0.98
34_H 38_S 1.603 0.98
57_I 300_A 1.599 0.98
141_T 156_I 1.596 0.98
242_A 290_N 1.586 0.98
281_C 336_L 1.571 0.97
72_A 132_V 1.562 0.97
243_D 247_A 1.558 0.97
238_P 244_D 1.548 0.97
85_R 341_A 1.53 0.97
78_L 334_E 1.512 0.96
242_A 283_D 1.509 0.96
74_R 304_L 1.505 0.96
31_V 133_N 1.493 0.96
82_Y 337_V 1.482 0.96
40_R 44_K 1.482 0.96
278_L 332_D 1.478 0.96
55_V 337_V 1.466 0.96
54_L 89_V 1.459 0.95
56_I 262_V 1.443 0.95
70_E 74_R 1.435 0.95
334_E 338_E 1.434 0.95
31_V 34_H 1.425 0.95
69_M 73_T 1.414 0.94
30_G 134_E 1.408 0.94
246_A 250_D 1.389 0.94
65_L 69_M 1.381 0.93
300_A 336_L 1.376 0.93
159_G 197_D 1.371 0.93
6_E 9_T 1.366 0.93
300_A 328_L 1.361 0.93
273_Q 276_R 1.356 0.93
331_E 334_E 1.354 0.92
78_L 338_E 1.348 0.92
247_A 251_T 1.344 0.92
82_Y 88_I 1.315 0.91
150_Q 179_S 1.311 0.91
74_R 330_W 1.296 0.90
179_S 208_F 1.288 0.90
78_L 81_Q 1.28 0.89
78_L 82_Y 1.267 0.89
242_A 286_Q 1.265 0.89
212_D 218_T 1.254 0.88
285_C 340_L 1.252 0.88
94_F 129_L 1.234 0.87
242_A 246_A 1.233 0.87
43_E 227_Y 1.232 0.87
306_E 332_D 1.229 0.87
238_P 241_H 1.22 0.86
19_A 214_N 1.22 0.86
70_E 73_T 1.217 0.86
16_V 119_N 1.209 0.85
4_T 7_L 1.198 0.85
199_I 230_I 1.198 0.85
262_V 296_A 1.194 0.85
10_A 223_S 1.193 0.84
314_S 347_R 1.192 0.84
20_E 23_L 1.191 0.84
40_R 43_E 1.189 0.84
133_N 139_T 1.188 0.84
281_C 298_I 1.184 0.84
285_C 344_V 1.181 0.84
210_S 220_Y 1.175 0.83
341_A 345_D 1.155 0.82
260_H 296_A 1.151 0.81
106_L 124_L 1.146 0.81
38_S 42_I 1.144 0.81
285_C 339_K 1.141 0.81
314_S 348_F 1.14 0.81
73_T 77_S 1.136 0.80
82_Y 341_A 1.136 0.80
187_G 191_N 1.132 0.80
28_T 134_E 1.132 0.80
248_A 261_L 1.131 0.80
329_G 335_R 1.121 0.79
68_A 132_V 1.119 0.79
74_R 78_L 1.119 0.79
21_L 122_L 1.115 0.79
5_D 213_K 1.114 0.78
107_I 125_A 1.109 0.78
250_D 254_E 1.099 0.77
41_R 44_K 1.098 0.77
146_M 170_I 1.097 0.77
178_L 182_V 1.097 0.77
193_R 197_D 1.096 0.77
273_Q 278_L 1.094 0.77
94_F 125_A 1.094 0.77
69_M 135_L 1.09 0.76
193_R 251_T 1.09 0.76
149_G 179_S 1.087 0.76
14_S 20_E 1.082 0.76
274_H 329_G 1.08 0.75
237_K 244_D 1.072 0.75
81_Q 334_E 1.071 0.74
14_S 216_Q 1.057 0.73
55_V 86_L 1.053 0.73
270_C 326_P 1.048 0.72
246_A 294_A 1.034 0.71
46_L 260_H 1.032 0.71
166_T 184_F 1.027 0.70
119_N 219_I 1.019 0.69
252_L 259_E 1.016 0.69
328_L 332_D 1.016 0.69
77_S 80_N 1.014 0.69
67_A 319_Y 1.014 0.69
16_V 21_L 1.007 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1of8A20.99431000.194Contact Map0.757
1n8fA411000.2Contact Map0.797
4hsnA40.98851000.231Contact Map0.77
3tqkA10.98851000.238Contact Map0.711
4lu0A40.77591000.676Contact Map0.552
2nwrA20.70691000.677Contact Map0.572
1o60A40.74711000.702Contact Map0.574
1vs1A40.76721000.705Contact Map0.457
2qkfA40.72991000.713Contact Map0.541
3fs2A20.81321000.713Contact Map0.537

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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