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AROF - Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive
UniProt: P00888 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10078
Length: 356 (345)
Sequences: 1128
Seq/Len: 3.27

AROF
Paralog alert: 0.71 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: AROF AROG AROH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
243_S 246_D 5.523 1.00
83_E 341_R 4.366 1.00
113_H 122_A 4.304 1.00
72_E 306_I 4.155 1.00
46_D 51_R 3.799 1.00
321_K 324_V 3.37 1.00
307_H 324_V 3.31 1.00
82_A 85_S 3.248 1.00
308_E 332_S 3.1 1.00
26_A 125_Q 3.077 1.00
331_I 339_L 3.061 1.00
59_C 336_T 2.987 1.00
307_H 321_K 2.96 1.00
78_K 82_A 2.912 1.00
84_V 341_R 2.846 1.00
87_S 348_N 2.774 1.00
114_M 326_V 2.77 1.00
332_S 335_M 2.743 1.00
277_R 308_E 2.718 1.00
284_E 342_E 2.686 1.00
129_K 133_E 2.639 1.00
70_A 130_L 2.483 1.00
247_V 265_V 2.459 1.00
47_I 89_Y 2.396 1.00
276_Y 329_A 2.348 1.00
285_S 288_A 2.23 1.00
43_S 89_Y 2.228 1.00
255_E 261_P 2.182 1.00
27_F 132_L 2.14 1.00
313_S 326_V 2.135 1.00
39_D 43_S 2.115 1.00
278_R 281_A 2.107 1.00
119_D 122_A 2.083 1.00
72_E 322_Y 1.991 1.00
113_H 119_D 1.964 1.00
44_I 91_V 1.963 1.00
276_Y 308_E 1.908 1.00
130_L 134_L 1.9 1.00
81_A 89_Y 1.869 0.99
193_S 196_T 1.868 0.99
49_A 229_D 1.864 0.99
57_V 300_L 1.843 0.99
35_A 39_D 1.778 0.99
160_W 231_H 1.694 0.99
265_V 286_V 1.692 0.99
251_E 296_S 1.684 0.99
59_C 302_I 1.684 0.99
267_C 283_A 1.674 0.98
343_I 347_L 1.672 0.98
344_H 348_N 1.652 0.98
71_L 75_R 1.644 0.98
68_E 75_R 1.644 0.98
251_E 294_N 1.607 0.98
74_A 134_L 1.602 0.98
244_P 292_D 1.599 0.98
316_P 319_E 1.593 0.98
75_R 137_M 1.59 0.98
76_R 306_I 1.589 0.98
87_S 344_H 1.582 0.98
143_T 158_F 1.582 0.98
72_E 76_R 1.56 0.97
36_Q 40_S 1.549 0.97
277_R 335_M 1.526 0.97
244_P 285_S 1.519 0.97
80_L 337_D 1.514 0.97
240_P 246_D 1.51 0.97
33_Q 135_V 1.488 0.96
337_D 341_R 1.486 0.96
58_V 264_M 1.483 0.96
84_V 340_L 1.477 0.96
42_K 46_D 1.474 0.96
57_V 340_L 1.444 0.95
245_A 249_Q 1.438 0.95
280_P 335_M 1.437 0.95
8_N 11_I 1.423 0.95
302_I 331_I 1.418 0.95
283_A 339_L 1.407 0.94
302_I 339_L 1.404 0.94
248_A 252_K 1.392 0.94
161_S 199_N 1.381 0.93
33_Q 36_Q 1.373 0.93
80_L 341_R 1.372 0.93
67_P 71_L 1.371 0.93
249_Q 253_E 1.353 0.93
56_L 91_V 1.343 0.92
32_Q 136_N 1.322 0.91
275_D 278_R 1.317 0.91
308_E 335_M 1.306 0.91
181_S 210_F 1.305 0.91
152_Q 181_S 1.297 0.90
80_L 84_V 1.295 0.90
214_N 220_A 1.288 0.90
287_V 343_I 1.285 0.90
75_R 79_A 1.284 0.90
84_V 90_L 1.281 0.90
6_L 9_V 1.275 0.89
96_F 131_L 1.271 0.89
45_S 229_D 1.259 0.88
80_L 83_E 1.252 0.88
76_R 333_W 1.241 0.88
287_V 347_L 1.24 0.87
314_E 317_R 1.233 0.87
18_M 121_E 1.232 0.87
244_P 248_A 1.218 0.86
201_M 232_V 1.207 0.85
71_L 137_M 1.203 0.85
334_E 337_D 1.196 0.85
76_R 80_L 1.194 0.85
240_P 243_S 1.19 0.84
287_V 342_E 1.185 0.84
42_K 45_S 1.183 0.84
40_S 44_I 1.175 0.83
70_A 134_L 1.168 0.83
264_M 298_I 1.158 0.82
23_L 124_L 1.154 0.82
135_V 141_L 1.148 0.81
252_K 256_Q 1.144 0.81
148_P 172_T 1.14 0.81
212_G 222_L 1.137 0.80
109_I 127_A 1.135 0.80
244_P 288_A 1.13 0.80
262_S 298_I 1.126 0.80
250_C 263_L 1.126 0.80
22_Q 25_A 1.125 0.80
283_A 300_L 1.124 0.79
84_V 344_H 1.114 0.79
96_F 127_A 1.112 0.78
189_G 193_S 1.105 0.78
195_A 199_N 1.103 0.78
72_E 75_R 1.098 0.77
283_A 287_V 1.093 0.77
195_A 253_E 1.087 0.76
338_A 342_E 1.081 0.76
12_T 225_Q 1.079 0.75
276_Y 332_S 1.078 0.75
122_A 126_I 1.077 0.75
275_D 280_P 1.077 0.75
151_P 181_S 1.07 0.75
7_N 215_Q 1.067 0.74
16_V 22_Q 1.064 0.74
21_E 216_A 1.064 0.74
16_V 218_Q 1.061 0.74
180_L 184_V 1.06 0.74
30_S 136_N 1.055 0.73
270_G 273_N 1.052 0.73
332_S 338_A 1.043 0.72
33_Q 136_N 1.037 0.71
331_I 335_M 1.034 0.71
27_F 129_K 1.03 0.71
43_S 46_D 1.029 0.70
108_L 126_I 1.024 0.70
272_S 329_A 1.02 0.69
248_A 296_S 1.019 0.69
69_T 322_Y 1.017 0.69
341_R 345_Q 1.013 0.69
168_T 186_F 1.007 0.68
132_L 157_L 1.004 0.68
57_V 88_L 1.002 0.67
18_M 23_L 1.001 0.67
201_M 230_G 1 0.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1of8A20.99441000.214Contact Map0.764
1n8fA40.98311000.222Contact Map0.803
4hsnA40.98031000.252Contact Map0.765
3tqkA10.96911000.255Contact Map0.724
4lu0A40.77251000.682Contact Map0.553
2nwrA20.70221000.684Contact Map0.571
1o60A40.74441000.706Contact Map0.562
1vs1A40.74441000.71Contact Map0.489
3fs2A20.80061000.717Contact Map0.542
2qkfA40.72751000.718Contact Map0.535

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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