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TRPE - Anthranilate synthase component 1
UniProt: P00895 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11028
Length: 520 (487)
Sequences: 1917
Seq/Len: 3.94

TRPE
Paralog alert: 0.40 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: PABB TRPE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
426_L 450_G 5.057 1.00
378_T 406_E 4.898 1.00
128_R 412_D 4.304 1.00
377_C 405_G 4.092 1.00
378_T 409_H 3.521 1.00
330_R 351_E 3.11 1.00
242_D 246_G 3.018 1.00
245_F 484_A 2.989 1.00
152_Y 435_M 2.933 1.00
255_A 440_E 2.87 1.00
373_L 377_C 2.831 1.00
255_A 260_E 2.824 1.00
271_S 479_T 2.765 1.00
36_L 54_L 2.673 1.00
491_V 494_S 2.666 1.00
122_S 418_R 2.653 1.00
266_P 484_A 2.615 1.00
25_F 35_T 2.597 1.00
329_T 396_V 2.554 1.00
303_L 448_S 2.552 1.00
254_K 258_A 2.479 1.00
408_R 411_L 2.464 1.00
349_E 392_R 2.438 1.00
320_Q 404_V 2.433 1.00
454_G 464_T 2.398 1.00
346_S 349_E 2.387 1.00
24_L 184_I 2.368 1.00
122_S 125_D 2.367 1.00
240_Q 248_V 2.304 1.00
271_S 477_I 2.303 1.00
247_G 250_R 2.283 1.00
246_G 493_Q 2.282 1.00
385_A 404_V 2.254 1.00
242_D 493_Q 2.25 1.00
319_R 406_E 2.244 1.00
386_D 389_K 2.241 1.00
353_R 399_L 2.192 1.00
433_R 436_Q 2.161 1.00
273_P 477_I 2.117 1.00
433_R 440_E 2.054 1.00
390_V 399_L 2.038 1.00
376_I 419_A 2.022 1.00
294_F 305_G 2.005 1.00
350_L 354_T 1.994 1.00
383_Y 404_V 1.931 1.00
153_D 156_A 1.927 1.00
241_S 244_E 1.882 1.00
392_R 397_M 1.878 1.00
255_A 437_L 1.862 1.00
193_I 212_L 1.854 1.00
252_L 264_V 1.851 1.00
266_P 486_V 1.847 1.00
346_S 350_L 1.832 1.00
326_I 400_V 1.826 1.00
391_D 400_V 1.824 1.00
263_Q 485_G 1.821 1.00
239_N 444_R 1.793 0.99
277_P 302_T 1.784 0.99
411_L 415_H 1.745 0.99
244_E 443_G 1.741 0.99
24_L 219_L 1.735 0.99
320_Q 406_E 1.735 0.99
150_F 456_F 1.734 0.99
49_L 185_D 1.731 0.99
265_V 483_G 1.707 0.99
52_L 183_V 1.687 0.99
250_R 253_Q 1.668 0.99
294_F 453_V 1.655 0.99
448_S 467_V 1.652 0.99
332_R 345_D 1.652 0.99
261_I 264_V 1.636 0.99
324_Y 391_D 1.614 0.99
255_A 433_R 1.592 0.98
473_V 478_A 1.577 0.98
448_S 472_L 1.564 0.98
252_L 261_I 1.564 0.98
336_A 346_S 1.556 0.98
153_D 445_R 1.547 0.98
374_A 380_G 1.532 0.98
321_I 373_L 1.53 0.98
378_T 381_S 1.51 0.98
497_D 501_N 1.508 0.98
297_Q 302_T 1.5 0.97
494_S 497_D 1.486 0.97
437_L 441_A 1.484 0.97
484_A 499_T 1.481 0.97
280_A 473_V 1.48 0.97
366_V 387_L 1.473 0.97
244_E 247_G 1.473 0.97
180_T 211_R 1.466 0.97
62_T 69_T 1.458 0.97
153_D 439_A 1.457 0.97
304_F 473_V 1.455 0.97
19_D 27_Q 1.45 0.97
252_L 266_P 1.445 0.97
183_V 194_Q 1.441 0.97
385_A 402_R 1.432 0.96
324_Y 386_D 1.43 0.96
323_I 369_A 1.429 0.96
305_G 465_C 1.429 0.96
294_F 465_C 1.428 0.96
164_L 439_A 1.424 0.96
480_V 507_L 1.416 0.96
423_M 466_I 1.411 0.96
250_R 257_R 1.406 0.96
305_G 453_V 1.404 0.96
471_A 478_A 1.402 0.96
493_Q 497_D 1.402 0.96
156_A 439_A 1.401 0.96
268_R 499_T 1.4 0.96
150_F 154_L 1.392 0.96
347_R 351_E 1.391 0.96
267_S 481_Q 1.388 0.96
249_V 492_P 1.379 0.95
348_I 351_E 1.376 0.95
407_L 416_A 1.372 0.95
160_D 436_Q 1.363 0.95
242_D 496_A 1.348 0.94
327_A 425_T 1.345 0.94
193_I 216_R 1.34 0.94
480_V 503_A 1.324 0.94
334_R 338_G 1.318 0.94
378_T 408_R 1.313 0.93
193_I 215_L 1.312 0.93
290_S 395_Y 1.305 0.93
355_D 358_E 1.298 0.93
321_I 377_C 1.292 0.93
270_F 500_R 1.29 0.93
246_G 250_R 1.288 0.93
393_Y 400_V 1.284 0.92
331_P 338_G 1.282 0.92
327_A 362_H 1.281 0.92
158_F 421_M 1.268 0.92
300_D 474_E 1.266 0.92
452_A 464_T 1.266 0.92
274_C 280_A 1.263 0.92
455_Y 463_D 1.262 0.92
274_C 473_V 1.247 0.91
251_L 440_E 1.239 0.91
57_S 178_A 1.238 0.90
265_V 426_L 1.236 0.90
170_C 448_S 1.234 0.90
34_A 60_R 1.233 0.90
327_A 365_L 1.232 0.90
333_G 348_I 1.232 0.90
246_G 492_P 1.23 0.90
294_F 303_L 1.222 0.90
295_F 302_T 1.22 0.90
365_L 425_T 1.219 0.90
359_L 388_T 1.211 0.89
129_L 132_N 1.203 0.89
362_H 365_L 1.201 0.89
314_Y 416_A 1.194 0.88
293_M 306_A 1.193 0.88
324_Y 402_R 1.186 0.88
39_E 285_K 1.182 0.88
337_D 347_R 1.178 0.87
264_V 437_L 1.174 0.87
471_A 506_V 1.171 0.87
205_K 209_T 1.171 0.87
310_S 463_D 1.162 0.86
123_V 157_G 1.162 0.86
252_L 486_V 1.161 0.86
265_V 450_G 1.148 0.85
254_K 257_R 1.146 0.85
437_L 440_E 1.143 0.85
310_S 324_Y 1.142 0.85
439_A 445_R 1.139 0.85
281_Y 285_K 1.137 0.85
331_P 334_R 1.136 0.85
276_S 279_A 1.135 0.85
496_A 499_T 1.129 0.84
125_D 129_L 1.126 0.84
417_Y 456_F 1.124 0.84
257_R 488_L 1.118 0.83
277_P 473_V 1.115 0.83
242_D 497_D 1.114 0.83
363_L 388_T 1.114 0.83
251_L 255_A 1.113 0.83
417_Y 464_T 1.113 0.83
265_V 427_S 1.107 0.83
167_E 444_R 1.106 0.82
349_E 397_M 1.1 0.82
414_L 456_F 1.099 0.82
283_V 512_T 1.099 0.82
268_R 496_A 1.095 0.82
238_C 499_T 1.092 0.81
363_L 387_L 1.087 0.81
423_M 465_C 1.086 0.81
497_D 500_R 1.077 0.80
338_G 347_R 1.072 0.80
263_Q 487_V 1.065 0.79
362_H 425_T 1.062 0.79
251_L 254_K 1.061 0.79
311_S 323_I 1.058 0.78
248_V 266_P 1.052 0.78
349_E 390_V 1.05 0.78
245_F 266_P 1.049 0.78
324_Y 389_K 1.046 0.77
250_R 492_P 1.041 0.77
496_A 500_R 1.039 0.77
39_E 281_Y 1.037 0.76
265_V 423_M 1.035 0.76
153_D 450_G 1.032 0.76
314_Y 407_L 1.032 0.76
153_D 435_M 1.024 0.75
280_A 304_F 1.023 0.75
373_L 405_G 1.018 0.75
266_P 441_A 1.017 0.74
252_L 441_A 1.013 0.74
358_E 365_L 1.012 0.74
321_I 405_G 1.011 0.74
423_M 426_L 1.009 0.74
23_A 27_Q 1.008 0.74
362_H 369_A 1.005 0.73
305_G 423_M 1.004 0.73
161_L 436_Q 1.001 0.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1i1qA111000.187Contact Map0.709
1k0eA20.85771000.26Contact Map0.819
4grhA10.86151000.279Contact Map0.619
1qdlA10.80191000.284Contact Map0.764
3logA40.84421000.322Contact Map0.709
3h9mA10.81541000.331Contact Map0.701
2fn0A20.82691000.371Contact Map0.705
3gseA10.81351000.429Contact Map0.655
3bzmA10.77311000.452Contact Map0.629
3hwoA20.74231000.462Contact Map0.681

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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