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ATKA - Potassium-transporting ATPase A chain
UniProt: P03959 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10513
Length: 557 (557)
Sequences: 628
Seq/Len: 1.13

ATKA
Paralog alert: 0.04 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
460_V 484_L 4.067 1.00
463_A 485_L 3.714 1.00
197_N 216_M 3.623 1.00
78_F 82_L 3.506 1.00
77_L 132_G 3.324 1.00
27_L 177_V 3.323 1.00
276_D 523_H 3.152 1.00
349_A 354_F 2.992 1.00
332_S 349_A 2.964 1.00
27_L 269_A 2.74 1.00
363_M 454_S 2.701 1.00
219_V 223_E 2.669 1.00
70_N 143_S 2.659 1.00
20_A 268_F 2.656 1.00
81_L 128_S 2.651 1.00
189_F 255_Q 2.647 1.00
435_A 480_F 2.64 1.00
192_Q 248_T 2.512 0.99
117_S 476_A 2.508 0.99
185_I 224_A 2.436 0.99
56_E 157_R 2.428 0.99
188_F 254_V 2.4 0.99
31_I 145_I 2.372 0.99
81_L 97_L 2.289 0.99
101_L 117_S 2.227 0.98
97_L 123_T 2.212 0.98
145_I 173_I 2.19 0.98
335_F 344_C 2.189 0.98
156_T 274_M 2.187 0.98
119_S 237_N 2.167 0.98
335_F 346_A 2.164 0.98
56_E 162_T 2.157 0.98
431_G 484_L 2.126 0.98
79_F 83_G 2.121 0.98
302_E 323_K 2.121 0.98
185_I 258_A 2.118 0.98
127_F 131_A 2.113 0.98
97_L 128_S 2.097 0.98
227_M 344_C 2.071 0.97
80_M 127_F 2.061 0.97
81_L 124_L 2.045 0.97
103_L 486_A 2.041 0.97
30_L 177_V 2.012 0.97
227_M 346_A 1.985 0.96
185_I 254_V 1.925 0.95
31_I 173_I 1.898 0.95
366_M 461_S 1.884 0.95
126_Y 201_Y 1.884 0.95
73_G 143_S 1.88 0.94
477_N 482_N 1.868 0.94
97_L 124_L 1.865 0.94
294_C 365_L 1.864 0.94
355_T 358_G 1.861 0.94
495_G 499_P 1.86 0.94
155_F 270_F 1.849 0.94
367_Q 461_S 1.83 0.93
80_M 128_S 1.781 0.92
428_V 465_N 1.763 0.92
286_A 532_I 1.759 0.91
125_S 128_S 1.739 0.91
99_W 103_L 1.718 0.90
412_R 416_L 1.713 0.90
267_C 280_G 1.708 0.90
371_V 535_V 1.703 0.90
63_L 501_M 1.696 0.89
154_A 508_V 1.696 0.89
279_Q 522_T 1.692 0.89
366_M 465_N 1.692 0.89
305_G 355_T 1.665 0.88
188_F 250_L 1.658 0.88
260_F 338_V 1.636 0.87
227_M 335_F 1.633 0.87
23_L 181_V 1.621 0.86
58_N 61_Q 1.602 0.85
15_V 253_F 1.598 0.85
101_L 477_N 1.597 0.85
103_L 483_C 1.587 0.85
85_H 96_G 1.576 0.84
282_M 528_V 1.559 0.83
496_V 499_P 1.557 0.83
78_F 99_W 1.546 0.83
446_L 455_E 1.533 0.82
94_L 123_T 1.528 0.82
181_V 185_I 1.523 0.81
82_L 99_W 1.52 0.81
436_M 445_M 1.515 0.81
358_G 362_P 1.51 0.80
380_L 384_M 1.495 0.80
86_Y 96_G 1.494 0.79
487_F 491_V 1.489 0.79
410_D 510_K 1.486 0.79
168_V 171_L 1.477 0.78
206_T 209_G 1.467 0.78
59_W 502_A 1.46 0.77
285_W 528_V 1.458 0.77
283_L 383_M 1.457 0.77
19_L 257_L 1.441 0.76
390_A 534_T 1.441 0.76
444_A 475_S 1.438 0.76
464_A 488_C 1.438 0.76
57_M 365_L 1.437 0.76
134_T 198_F 1.437 0.76
66_I 147_V 1.433 0.75
427_L 464_A 1.432 0.75
26_G 30_L 1.413 0.74
107_V 490_F 1.41 0.74
436_M 456_V 1.403 0.73
238_A 346_A 1.392 0.72
70_N 73_G 1.392 0.72
196_Q 221_S 1.377 0.71
99_W 483_C 1.376 0.71
117_S 459_A 1.372 0.71
445_M 456_V 1.368 0.71
238_A 344_C 1.367 0.70
337_V 361_V 1.362 0.70
287_M 383_M 1.361 0.70
453_F 546_A 1.352 0.69
282_M 286_A 1.336 0.68
12_F 338_V 1.328 0.67
359_G 471_F 1.328 0.67
398_I 519_T 1.318 0.66
73_G 136_Q 1.316 0.66
284_L 288_S 1.314 0.66
28_A 269_A 1.308 0.66
336_A 354_F 1.304 0.65
195_L 216_M 1.303 0.65
343_S 376_V 1.299 0.65
148_I 335_F 1.297 0.65
260_F 342_A 1.297 0.65
298_V 337_V 1.296 0.64
291_F 338_V 1.278 0.63
59_W 505_G 1.271 0.62
83_G 86_Y 1.268 0.62
432_A 457_L 1.258 0.61
460_V 481_W 1.255 0.61
444_A 478_S 1.254 0.61
89_L 127_F 1.254 0.61
276_D 279_Q 1.243 0.60
352_D 447_N 1.242 0.60
223_E 335_F 1.241 0.59
439_D 442_R 1.241 0.59
355_T 362_P 1.237 0.59
45_V 49_A 1.233 0.59
115_W 459_A 1.229 0.58
432_A 453_F 1.226 0.58
219_V 236_F 1.225 0.58
483_C 486_A 1.224 0.58
160_M 163_L 1.213 0.57
110_V 136_Q 1.206 0.56
472_A 476_A 1.204 0.56
126_Y 235_F 1.204 0.56
336_A 349_A 1.2 0.56
459_A 470_A 1.198 0.55
47_F 171_L 1.194 0.55
276_D 404_Y 1.188 0.55
478_S 482_N 1.186 0.54
270_F 522_T 1.185 0.54
145_I 266_L 1.183 0.54
441_G 444_A 1.183 0.54
53_S 278_R 1.179 0.54
474_L 481_W 1.177 0.53
21_R 25_S 1.17 0.53
332_S 354_F 1.154 0.51
534_T 537_L 1.154 0.51
336_A 351_H 1.15 0.51
424_T 543_F 1.146 0.50
115_W 470_A 1.146 0.50
286_A 528_V 1.145 0.50
191_Q 195_L 1.143 0.50
202_Q 216_M 1.141 0.50
341_A 373_F 1.139 0.50
421_I 538_V 1.139 0.50
23_L 262_I 1.137 0.50
10_A 14_L 1.136 0.50
41_G 44_R 1.132 0.49
332_S 336_A 1.128 0.49
537_L 544_I 1.127 0.49
19_L 261_L 1.124 0.48
203_A 211_Q 1.123 0.48
465_N 520_L 1.119 0.48
188_F 251_T 1.117 0.48
413_E 506_S 1.116 0.48
403_E 519_T 1.116 0.48
272_E 277_R 1.115 0.48
189_F 194_A 1.115 0.48
119_S 122_T 1.102 0.46
426_T 430_M 1.098 0.46
92_Q 201_Y 1.092 0.45
17_M 284_L 1.089 0.45
31_I 149_F 1.086 0.45
383_M 531_L 1.082 0.44
390_A 414_M 1.082 0.44
378_S 381_Y 1.082 0.44
194_A 240_S 1.071 0.43
122_T 435_A 1.071 0.43
148_I 344_C 1.071 0.43
227_M 255_Q 1.069 0.43
133_L 137_N 1.069 0.43
298_V 333_S 1.068 0.43
85_H 127_F 1.068 0.43
104_N 115_W 1.066 0.43
336_A 362_P 1.066 0.43
483_C 487_F 1.064 0.43
133_L 222_Q 1.064 0.43
470_A 476_A 1.06 0.42
126_Y 197_N 1.058 0.42
101_L 482_N 1.056 0.42
89_L 198_F 1.045 0.41
430_M 434_L 1.045 0.41
107_V 111_T 1.044 0.41
431_G 460_V 1.044 0.41
12_F 342_A 1.042 0.41
16_L 257_L 1.039 0.40
444_A 481_W 1.037 0.40
137_N 343_S 1.037 0.40
319_N 355_T 1.035 0.40
370_E 382_G 1.029 0.39
137_N 222_Q 1.028 0.39
281_R 285_W 1.027 0.39
427_L 491_V 1.026 0.39
447_N 474_L 1.026 0.39
136_Q 222_Q 1.021 0.39
521_P 524_G 1.021 0.39
267_C 287_M 1.021 0.39
335_F 338_V 1.018 0.38
438_T 441_G 1.018 0.38
62_Y 169_D 1.015 0.38
23_L 265_A 1.015 0.38
259_I 343_S 1.011 0.38
417_T 544_I 1.011 0.38
319_N 353_S 1.011 0.38
227_M 260_F 1.01 0.38
195_L 465_N 1.006 0.37
148_I 346_A 1.004 0.37
27_L 31_I 1.004 0.37
264_T 373_F 1.003 0.37
117_S 481_W 1.002 0.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pjzA20.79531000.822Contact Map0.361
4j7cI40.77741000.83Contact Map0.412
3qnqA40.2424110.99Contact Map0.276
2l92A10.08445.60.991Contact Map0
4h44F10.06140.992Contact Map0.361
2ih3C10.21363.30.992Contact Map0.371
2k1eA40.18493.20.992Contact Map0.52
3nd0A20.098730.992Contact Map0.6
2k3cA10.05922.80.992Contact Map0
4gx0A40.24782.80.992Contact Map0.542

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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