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ATKB - Potassium-transporting ATPase B chain
UniProt: P03960 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10514
Length: 682 (636)
Sequences: 4368
Seq/Len: 6.87

ATKB
Paralog alert: 0.66 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: ATKB ATMA ATZN COPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
144_G 189_I 6.918 1.00
302_D 511_R 4.451 1.00
132_V 144_G 3.951 1.00
132_V 189_I 3.61 1.00
482_A 490_F 3.609 1.00
336_A 440_L 3.306 1.00
507_Q 528_Q 3.281 1.00
321_E 426_Q 3.066 1.00
144_G 176_V 3.058 1.00
504_R 528_Q 2.974 1.00
37_F 41_I 2.963 1.00
452_G 554_N 2.885 1.00
142_C 191_C 2.874 1.00
132_V 141_P 2.748 1.00
105_F 120_K 2.662 1.00
128_K 194_N 2.659 1.00
534_A 546_G 2.63 1.00
423_V 444_A 2.626 1.00
153_V 182_I 2.588 1.00
131_I 147_I 2.557 1.00
459_Q 563_H 2.517 1.00
314_L 451_G 2.492 1.00
271_L 275_G 2.486 1.00
176_V 189_I 2.438 1.00
416_V 439_V 2.417 1.00
270_L 275_G 2.416 1.00
109_L 188_V 2.379 1.00
134_V 140_I 2.325 1.00
126_L 191_C 2.324 1.00
419_K 422_Q 2.285 1.00
148_E 188_V 2.282 1.00
107_R 138_D 2.276 1.00
285_A 563_H 2.267 1.00
107_R 135_E 2.252 1.00
458_A 462_K 2.231 1.00
179_G 200_L 2.22 1.00
82_A 86_A 2.196 1.00
289_A 548_M 2.192 1.00
465_I 562_V 2.144 1.00
457_F 487_V 2.136 1.00
285_A 560_E 2.116 1.00
144_G 192_S 2.105 1.00
83_E 86_A 2.07 1.00
471_T 478_A 2.064 1.00
336_A 393_I 2.042 1.00
267_I 275_G 2.04 1.00
126_L 132_V 2.015 1.00
151_A 187_L 1.992 1.00
454_K 458_A 1.985 1.00
479_A 483_A 1.985 1.00
452_G 455_E 1.983 1.00
370_L 387_N 1.973 1.00
468_V 506_Y 1.956 1.00
460_L 559_I 1.949 1.00
153_V 176_V 1.934 1.00
272_S 275_G 1.924 1.00
312_I 485_A 1.922 1.00
334_A 355_L 1.921 1.00
432_V 439_V 1.913 1.00
407_A 410_G 1.883 1.00
428_A 444_A 1.866 1.00
435_E 438_R 1.862 1.00
418_Q 422_Q 1.86 1.00
267_I 271_L 1.856 1.00
175_S 192_S 1.842 1.00
189_I 192_S 1.82 1.00
64_F 68_I 1.818 1.00
385_G 388_I 1.811 1.00
270_L 276_V 1.81 1.00
268_G 275_G 1.805 1.00
252_V 256_V 1.803 1.00
430_P 442_V 1.8 1.00
333_L 441_G 1.8 1.00
287_V 557_K 1.767 1.00
354_I 358_Q 1.765 1.00
107_R 118_A 1.752 1.00
233_L 237_A 1.74 1.00
384_S 392_M 1.732 1.00
121_V 126_L 1.729 1.00
269_G 275_G 1.709 1.00
384_S 388_I 1.698 1.00
32_R 37_F 1.697 1.00
243_S 251_S 1.685 1.00
267_I 270_L 1.677 1.00
214_K 222_T 1.672 1.00
518_D 521_N 1.672 1.00
319_A 355_L 1.666 1.00
199_F 202_R 1.66 1.00
332_T 435_E 1.653 1.00
86_A 90_S 1.652 1.00
140_I 153_V 1.646 1.00
505_Q 508_A 1.642 1.00
421_D 476_L 1.64 1.00
383_M 388_I 1.639 1.00
131_I 190_E 1.636 1.00
338_Q 356_A 1.63 1.00
526_L 542_A 1.625 1.00
417_D 421_D 1.62 1.00
578_F 582_N 1.62 1.00
118_A 133_L 1.61 1.00
272_S 276_V 1.608 1.00
288_I 551_L 1.606 1.00
145_E 190_E 1.598 1.00
423_V 428_A 1.593 1.00
533_V 558_L 1.577 1.00
105_F 122_P 1.577 1.00
301_V 514_A 1.571 1.00
270_L 274_I 1.57 1.00
427_G 480_A 1.568 1.00
68_I 79_A 1.565 1.00
121_V 125_Q 1.562 1.00
152_S 184_S 1.552 0.99
40_W 44_L 1.546 0.99
461_R 467_T 1.536 0.99
470_I 502_L 1.531 0.99
271_L 274_I 1.523 0.99
394_R 401_I 1.518 0.99
286_N 551_L 1.511 0.99
449_V 485_A 1.506 0.99
286_N 557_K 1.494 0.99
303_V 468_V 1.492 0.99
401_I 434_V 1.492 0.99
109_L 118_A 1.487 0.99
271_L 276_V 1.478 0.99
575_L 579_S 1.475 0.99
146_V 149_G 1.472 0.99
202_R 497_E 1.466 0.99
176_V 182_I 1.462 0.99
316_N 319_A 1.459 0.99
425_R 476_L 1.457 0.99
75_T 79_A 1.457 0.99
82_A 85_L 1.455 0.99
85_L 89_R 1.454 0.99
507_Q 530_D 1.446 0.99
491_L 502_L 1.442 0.99
155_E 167_R 1.441 0.99
531_V 548_M 1.436 0.99
452_G 556_T 1.423 0.99
146_V 187_L 1.417 0.99
122_P 125_Q 1.414 0.99
482_A 487_V 1.401 0.99
133_L 188_V 1.39 0.99
146_V 176_V 1.385 0.99
469_M 482_A 1.38 0.99
456_R 556_T 1.377 0.98
414_T 418_Q 1.372 0.98
470_I 494_A 1.372 0.98
66_A 70_G 1.368 0.98
355_L 443_I 1.367 0.98
107_R 120_K 1.365 0.98
136_A 378_T 1.357 0.98
384_S 394_R 1.356 0.98
266_T 269_G 1.34 0.98
460_L 467_T 1.337 0.98
269_G 274_I 1.334 0.98
433_V 443_I 1.326 0.98
364_E 368_Q 1.322 0.98
475_R 479_A 1.319 0.98
420_V 430_P 1.306 0.98
422_Q 426_Q 1.306 0.98
269_G 272_S 1.3 0.98
230_I 234_L 1.299 0.98
398_V 420_V 1.294 0.97
620_A 624_N 1.291 0.97
446_K 484_E 1.29 0.97
109_L 131_I 1.286 0.97
323_I 419_K 1.286 0.97
455_E 459_Q 1.281 0.97
146_V 189_I 1.281 0.97
86_A 91_K 1.276 0.97
134_V 182_I 1.275 0.97
321_E 428_A 1.267 0.97
267_I 272_S 1.265 0.97
319_A 445_L 1.264 0.97
134_V 138_D 1.258 0.97
305_L 506_Y 1.257 0.97
290_T 546_G 1.256 0.97
514_A 533_V 1.254 0.97
213_R 507_Q 1.253 0.97
69_S 76_V 1.25 0.97
173_F 177_T 1.248 0.97
418_Q 421_D 1.247 0.97
337_A 443_I 1.246 0.97
182_I 187_L 1.244 0.97
64_F 79_A 1.242 0.97
504_R 508_A 1.241 0.97
268_G 271_L 1.236 0.96
151_A 182_I 1.228 0.96
336_A 433_V 1.225 0.96
206_M 497_E 1.224 0.96
401_I 432_V 1.224 0.96
88_G 92_A 1.219 0.96
420_V 442_V 1.218 0.96
315_G 319_A 1.215 0.96
321_E 423_V 1.21 0.96
320_S 484_E 1.209 0.96
301_V 562_V 1.207 0.96
401_I 405_V 1.207 0.96
287_V 561_V 1.205 0.96
86_A 89_R 1.201 0.96
316_N 358_Q 1.201 0.96
286_N 552_D 1.197 0.96
405_V 434_V 1.189 0.95
560_E 563_H 1.189 0.95
266_T 271_L 1.189 0.95
110_R 127_R 1.184 0.95
68_I 76_V 1.181 0.95
79_A 83_E 1.18 0.95
552_D 557_K 1.178 0.95
352_I 443_I 1.176 0.95
69_S 72_L 1.175 0.95
319_A 352_I 1.17 0.95
535_M 538_G 1.167 0.95
63_L 66_A 1.161 0.94
110_R 130_D 1.155 0.94
266_T 275_G 1.151 0.94
267_I 276_V 1.149 0.94
127_R 194_N 1.146 0.94
226_I 230_I 1.145 0.94
512_L 530_D 1.145 0.94
570_M 574_S 1.143 0.94
108_K 127_R 1.14 0.94
154_D 157_A 1.138 0.94
221_L 274_I 1.138 0.94
240_W 255_L 1.136 0.94
31_W 76_V 1.132 0.93
66_A 69_S 1.129 0.93
223_I 227_A 1.127 0.93
582_N 586_K 1.125 0.93
43_S 65_S 1.123 0.93
421_D 425_R 1.121 0.93
478_A 492_A 1.121 0.93
268_G 276_V 1.12 0.93
301_V 531_V 1.119 0.93
398_V 432_V 1.115 0.93
149_G 176_V 1.114 0.93
135_E 186_W 1.111 0.93
405_V 439_V 1.11 0.93
106_A 123_A 1.109 0.93
455_E 458_A 1.109 0.93
315_G 318_Q 1.106 0.92
108_K 121_V 1.104 0.92
75_T 80_N 1.104 0.92
394_R 437_S 1.103 0.92
382_R 397_S 1.097 0.92
332_T 393_I 1.096 0.92
281_R 564_I 1.096 0.92
224_L 576_T 1.096 0.92
435_E 440_L 1.095 0.92
304_L 467_T 1.091 0.92
466_K 489_D 1.088 0.92
477_T 481_I 1.077 0.91
507_Q 526_L 1.071 0.91
68_I 75_T 1.07 0.91
123_A 126_L 1.068 0.91
34_P 225_L 1.067 0.90
307_D 311_T 1.061 0.90
312_I 449_V 1.059 0.90
68_I 72_L 1.056 0.90
79_A 82_A 1.055 0.90
383_M 386_I 1.053 0.90
267_I 274_I 1.053 0.90
379_A 382_R 1.05 0.90
342_L 371_H 1.049 0.89
71_W 75_T 1.048 0.89
391_R 435_E 1.047 0.89
31_W 40_W 1.046 0.89
47_T 65_S 1.045 0.89
92_A 95_N 1.045 0.89
153_V 187_L 1.044 0.89
269_G 276_V 1.042 0.89
460_L 555_P 1.041 0.89
340_A 460_L 1.037 0.89
33_N 36_M 1.037 0.89
459_Q 462_K 1.036 0.89
503_I 513_V 1.036 0.89
145_E 175_S 1.036 0.89
18_L 22_V 1.036 0.89
304_L 514_A 1.035 0.89
381_S 384_S 1.033 0.89
472_G 521_N 1.029 0.88
303_V 506_Y 1.025 0.88
500_L 528_Q 1.025 0.88
64_F 69_S 1.022 0.88
179_G 500_L 1.018 0.88
311_T 521_N 1.017 0.87
491_L 506_Y 1.017 0.87
305_L 470_I 1.01 0.87
467_T 555_P 1.01 0.87
377_F 382_R 1.009 0.87
31_W 34_P 1.009 0.87
425_R 479_A 1.006 0.87
319_A 443_I 1.005 0.87
158_I 177_T 1.003 0.86
377_F 397_S 1.003 0.86
446_K 449_V 1.003 0.86
111_E 117_A 1 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ar4A10.95751000.274Contact Map0.694
2zxeA10.96191000.283Contact Map0.667
3ixzA10.95751000.283Contact Map0.067
1mhsA20.93991000.29Contact Map0.524
3b8cA20.94721000.294Contact Map0.528
3rfuA40.87831000.384Contact Map0.532
3j09A20.88271000.413Contact Map0.652
3j08A20.88271000.419Contact Map0.635
3a1cA20.41641000.799Contact Map0.745
3skxA10.41061000.803Contact Map0.682

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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