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3MG2 - DNA-3-methyladenine glycosylase 2
UniProt: P04395 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11222
Length: 282 (275)
Sequences: 939
Seq/Len: 3.41

3MG2
Paralog alert: 0.17 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
79_S 85_Q 2.798 1.00
240_L 244_R 2.726 1.00
258_E 261_K 2.671 1.00
157_T 160_R 2.445 1.00
144_E 160_R 2.416 1.00
206_M 221_N 2.335 1.00
133_K 137_R 2.246 1.00
177_K 180_E 2.099 1.00
232_D 264_R 2.077 1.00
225_L 265_S 1.916 1.00
121_I 185_L 1.905 1.00
122_L 135_T 1.851 0.99
124_Q 218_W 1.826 0.99
208_T 211_T 1.811 0.99
210_Q 220_A 1.782 0.99
122_L 134_L 1.771 0.99
240_L 243_Q 1.756 0.99
233_V 265_S 1.726 0.99
117_G 185_L 1.723 0.99
87_N 90_I 1.691 0.99
239_Y 243_Q 1.69 0.99
184_H 212_F 1.648 0.98
41_V 44_Y 1.646 0.98
260_W 267_A 1.625 0.98
11_D 14_W 1.614 0.98
180_E 184_H 1.61 0.98
120_A 222_Y 1.609 0.98
117_G 223_F 1.605 0.98
188_A 212_F 1.542 0.97
37_R 115_E 1.541 0.97
114_F 158_P 1.533 0.97
31_A 34_Y 1.467 0.96
36_A 49_T 1.453 0.96
125_L 130_M 1.451 0.96
40_A 144_E 1.451 0.96
210_Q 217_R 1.446 0.96
83_D 86_C 1.44 0.95
16_L 30_V 1.417 0.95
204_Q 208_T 1.409 0.95
235_L 265_S 1.408 0.95
96_G 100_A 1.394 0.94
138_V 161_L 1.389 0.94
127_S 130_M 1.357 0.93
175_P 178_R 1.332 0.92
82_F 112_D 1.327 0.92
86_C 91_V 1.326 0.92
114_F 118_V 1.325 0.92
141_L 168_A 1.324 0.92
114_F 186_A 1.307 0.91
10_Y 15_M 1.304 0.91
183_I 187_N 1.296 0.91
125_L 218_W 1.295 0.91
188_A 211_T 1.275 0.90
178_R 216_G 1.275 0.90
219_T 272_W 1.273 0.90
189_A 196_M 1.267 0.90
22_R 128_V 1.261 0.89
136_A 140_Q 1.251 0.89
126_V 218_W 1.243 0.88
131_A 218_W 1.242 0.88
83_D 266_Y 1.241 0.88
49_T 62_N 1.22 0.87
89_Q 215_I 1.21 0.87
224_A 230_A 1.209 0.86
134_L 172_L 1.202 0.86
236_P 254_R 1.198 0.86
123_G 222_Y 1.198 0.86
129_A 132_A 1.198 0.86
126_V 219_T 1.193 0.85
22_R 120_A 1.185 0.85
159_Q 190_L 1.182 0.85
201_D 204_Q 1.18 0.85
124_Q 219_T 1.178 0.84
124_Q 216_G 1.174 0.84
50_A 82_F 1.174 0.84
117_G 121_I 1.171 0.84
80_R 85_Q 1.166 0.84
202_V 224_A 1.15 0.82
59_L 101_A 1.145 0.82
205_A 228_W 1.145 0.82
103_P 262_P 1.144 0.82
188_A 193_T 1.141 0.82
39_L 111_V 1.139 0.82
130_M 178_R 1.131 0.81
62_N 78_M 1.128 0.81
265_S 268_L 1.124 0.80
24_V 135_T 1.123 0.80
121_I 181_A 1.12 0.80
17_G 20_A 1.114 0.80
235_L 268_L 1.111 0.79
235_L 241_I 1.111 0.79
126_V 181_A 1.105 0.79
22_R 35_Y 1.097 0.78
206_M 210_Q 1.09 0.78
261_K 264_R 1.089 0.77
192_G 195_P 1.085 0.77
102_R 121_I 1.083 0.77
248_M 256_Y 1.083 0.77
241_I 245_F 1.076 0.76
134_L 173_G 1.073 0.76
184_H 187_N 1.07 0.76
218_W 238_D 1.069 0.76
26_S 139_A 1.068 0.76
161_L 165_D 1.067 0.75
91_V 266_Y 1.066 0.75
232_D 261_K 1.058 0.75
123_G 219_T 1.057 0.74
51_I 215_I 1.054 0.74
206_M 224_A 1.05 0.74
131_A 219_T 1.048 0.74
64_S 67_L 1.045 0.73
218_W 222_Y 1.045 0.73
121_I 182_L 1.044 0.73
98_L 270_H 1.043 0.73
13_S 33_S 1.042 0.73
12_W 52_P 1.041 0.73
16_L 267_A 1.037 0.72
128_V 222_Y 1.034 0.72
11_D 43_E 1.03 0.72
74_C 82_F 1.028 0.72
232_D 262_P 1.028 0.72
117_G 215_I 1.024 0.71
83_D 231_K 1.022 0.71
122_L 126_V 1.02 0.71
130_M 173_G 1.02 0.71
39_L 74_C 1.019 0.71
110_C 229_Q 1.016 0.70
210_Q 221_N 1.016 0.70
37_R 109_G 1.015 0.70
162_A 192_G 1.012 0.70
123_G 272_W 1.012 0.70
184_H 188_A 1.004 0.69
265_S 272_W 1 0.68
126_V 178_R 1 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1mpgA211000.139Contact Map0.64
2jhnA20.97161000.226Contact Map0.583
3i0wA10.93261000.302Contact Map0.634
4ejyA20.93971000.313Contact Map0.623
2xhiA10.95741000.333Contact Map0.545
4b21A10.75181000.409Contact Map0.614
2yg9A20.75531000.47Contact Map0.566
2h56A30.74111000.479Contact Map0.666
3s6iA20.73761000.491Contact Map0.627
3fhgA10.65251000.619Contact Map0.479

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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