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ALKB - Alpha-ketoglutarate-dependent dioxygenase AlkB
UniProt: P05050 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10037
Length: 216 (214)
Sequences: 476
Seq/Len: 2.22

ALKB
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
36_D 95_S 3.353 1.00
150_L 195_G 3.175 1.00
41_A 62_T 2.563 1.00
67_L 213_G 2.424 1.00
134_K 186_Y 2.21 1.00
16_A 182_S 2.167 1.00
18_G 181_E 2.115 1.00
63_N 116_A 2.107 1.00
103_A 144_V 1.954 0.99
49_M 71_T 1.932 0.99
160_K 163_D 1.888 0.99
182_S 185_F 1.749 0.97
62_T 119_I 1.691 0.97
146_V 175_V 1.687 0.97
200_T 203_C 1.664 0.96
169_L 185_F 1.642 0.96
44_S 85_T 1.596 0.95
19_A 182_S 1.572 0.95
115_D 212_A 1.525 0.93
18_G 182_S 1.523 0.93
30_A 200_T 1.445 0.91
48_Q 56_T 1.44 0.90
158_G 163_D 1.424 0.90
127_K 166_K 1.416 0.89
152_A 189_I 1.402 0.89
46_F 128_L 1.381 0.88
2_L 10_P 1.378 0.88
72_H 77_L 1.375 0.87
57_M 189_I 1.372 0.87
150_L 196_F 1.37 0.87
13_E 21_I 1.355 0.86
155_Q 190_Q 1.338 0.85
29_A 102_R 1.33 0.85
21_I 153_I 1.328 0.85
45_P 212_A 1.316 0.84
134_K 184_L 1.305 0.83
92_M 209_F 1.302 0.83
144_V 179_G 1.3 0.83
63_N 128_L 1.297 0.83
46_F 60_A 1.286 0.82
144_V 177_V 1.269 0.81
67_L 116_A 1.256 0.80
19_A 156_F 1.243 0.79
42_S 111_D 1.242 0.79
200_T 205_Y 1.24 0.79
3_D 6_A 1.237 0.79
156_F 176_V 1.236 0.79
22_L 175_V 1.235 0.79
50_V 53_G 1.23 0.78
70_T 79_S 1.219 0.77
94_Q 98_N 1.214 0.77
17_A 181_E 1.203 0.76
13_E 23_R 1.196 0.75
169_L 193_K 1.169 0.73
37_I 205_Y 1.164 0.73
55_Y 128_L 1.163 0.72
49_M 128_L 1.155 0.72
61_M 132_Q 1.151 0.71
204_R 210_R 1.144 0.71
109_Y 185_F 1.144 0.71
69_W 75_G 1.141 0.70
155_Q 191_P 1.141 0.70
59_V 128_L 1.14 0.70
47_R 82_D 1.139 0.70
22_L 103_A 1.139 0.70
2_L 70_T 1.134 0.70
2_L 12_Q 1.127 0.69
115_D 213_G 1.118 0.68
3_D 9_E 1.114 0.68
194_A 202_D 1.112 0.68
92_M 97_H 1.097 0.66
2_L 7_D 1.096 0.66
31_E 172_H 1.092 0.65
45_P 116_A 1.087 0.65
2_L 8_A 1.085 0.65
196_F 203_C 1.078 0.64
97_H 113_Q 1.074 0.64
33_L 148_L 1.074 0.64
35_R 38_N 1.074 0.64
27_F 172_H 1.069 0.63
24_R 171_E 1.065 0.63
18_G 31_E 1.063 0.62
2_L 165_L 1.062 0.62
55_Y 129_S 1.054 0.61
145_S 174_D 1.052 0.61
114_P 146_V 1.051 0.61
96_F 209_F 1.049 0.61
169_L 190_Q 1.047 0.61
114_P 175_V 1.044 0.60
2_L 11_W 1.044 0.60
63_N 143_I 1.042 0.60
55_Y 186_Y 1.042 0.60
8_A 12_Q 1.041 0.60
10_P 13_E 1.036 0.59
46_F 62_T 1.033 0.59
96_F 152_A 1.033 0.59
65_G 89_W 1.032 0.59
206_N 210_R 1.031 0.59
13_E 18_G 1.031 0.59
70_T 116_A 1.028 0.59
98_N 102_R 1.019 0.58
155_Q 165_L 1.011 0.57
63_N 85_T 1.008 0.56
3_D 11_W 1.001 0.56
6_A 10_P 1 0.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4jhtA10.95371000.375Contact Map0.546
3thtA40.92591000.589Contact Map0.393
3s57A10.8751000.602Contact Map0.367
2iuwA10.9121000.604Contact Map0.312
4ie5A10.921399.90.722Contact Map0.213
2jigA20.856595.80.921Contact Map0.189
3dkqA30.851994.30.928Contact Map0.217
4bqyA10.921393.70.93Contact Map0.201
3itqA20.83893.30.931Contact Map0.232
3kt7A10.856584.50.942Contact Map0.214

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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