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APPY - HTH-type transcriptional regulator AppY
UniProt: P05052 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10050
Length: 249 (236)
Sequences: 12676
Seq/Len: 53.71

APPY
Paralog alert: 0.79 [within 20: 0.30] - ratio of genomes with paralogs
Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
189_M 226_Y 3.401 1.00
201_Y 209_K 3.153 1.00
148_N 151_R 3.145 1.00
156_K 166_E 3.064 1.00
144_I 148_N 3.048 1.00
178_T 186_D 3.032 1.00
193_K 226_Y 3.01 1.00
146_S 187_T 2.877 1.00
191_Y 194_K 2.876 1.00
222_F 233_Y 2.717 1.00
192_A 218_F 2.439 1.00
186_D 225_Y 2.416 1.00
195_L 209_K 2.296 1.00
154_H 157_D 2.247 1.00
145_I 184_L 2.228 1.00
173_L 183_I 2.214 1.00
189_M 225_Y 2.083 1.00
15_D 22_V 2.066 1.00
195_L 201_Y 2.062 1.00
196_I 203_I 2.049 1.00
201_Y 205_V 2.008 1.00
195_L 210_C 1.922 1.00
202_S 205_V 1.911 1.00
191_Y 195_L 1.869 1.00
11_C 47_K 1.856 1.00
149_I 187_T 1.846 1.00
15_D 24_S 1.831 1.00
145_I 187_T 1.821 1.00
228_V 236_K 1.818 1.00
141_I 169_I 1.81 1.00
138_T 176_E 1.807 1.00
26_K 29_S 1.807 1.00
144_I 161_L 1.788 1.00
13_S 24_S 1.787 1.00
164_T 169_I 1.772 1.00
143_G 147_F 1.756 1.00
231_S 235_E 1.739 1.00
155_L 170_K 1.736 1.00
181_T 185_R 1.732 1.00
144_I 153_W 1.67 1.00
10_I 49_R 1.652 1.00
141_I 162_I 1.651 1.00
17_I 22_V 1.648 1.00
158_I 180_F 1.634 1.00
204_N 215_T 1.616 1.00
205_V 209_K 1.61 1.00
112_L 115_S 1.608 1.00
193_K 233_Y 1.607 1.00
13_S 26_K 1.598 1.00
168_L 172_R 1.594 1.00
142_T 176_E 1.589 1.00
192_A 210_C 1.57 1.00
199_N 234_F 1.566 1.00
219_I 229_T 1.555 1.00
111_R 118_A 1.553 1.00
179_S 182_E 1.52 1.00
217_Y 221_A 1.488 1.00
19_N 37_I 1.477 1.00
205_V 208_Q 1.473 1.00
166_E 170_K 1.464 1.00
164_T 168_L 1.457 1.00
194_K 198_S 1.457 1.00
169_I 180_F 1.456 1.00
146_S 183_I 1.454 1.00
168_L 171_K 1.45 1.00
156_K 160_E 1.43 1.00
141_I 158_I 1.413 1.00
17_I 40_E 1.412 1.00
34_S 37_I 1.392 0.99
228_V 232_H 1.383 0.99
221_A 224_D 1.382 0.99
149_I 191_Y 1.375 0.99
204_N 208_Q 1.374 0.99
151_R 157_D 1.36 0.99
180_F 184_L 1.35 0.99
206_V 210_C 1.346 0.99
15_D 42_P 1.337 0.99
167_S 171_K 1.333 0.99
191_Y 210_C 1.331 0.99
178_T 182_E 1.324 0.99
219_I 231_S 1.309 0.99
215_T 219_I 1.307 0.99
187_T 191_Y 1.303 0.99
214_S 220_C 1.293 0.99
216_S 219_I 1.289 0.99
92_F 96_E 1.283 0.99
203_I 206_V 1.268 0.99
157_D 161_L 1.267 0.99
229_T 232_H 1.259 0.99
142_T 146_S 1.257 0.99
11_C 27_K 1.257 0.99
111_R 115_S 1.245 0.98
158_I 161_L 1.238 0.98
115_S 119_M 1.231 0.98
212_Y 221_A 1.224 0.98
155_L 180_F 1.207 0.98
201_Y 206_V 1.198 0.98
137_F 164_T 1.171 0.98
187_T 190_R 1.17 0.97
199_N 206_V 1.166 0.97
165_S 168_L 1.15 0.97
220_C 224_D 1.148 0.97
144_I 158_I 1.144 0.97
137_F 162_I 1.139 0.97
5_C 39_R 1.13 0.97
170_K 180_F 1.126 0.97
186_D 190_R 1.115 0.96
111_R 114_I 1.101 0.96
159_A 166_E 1.095 0.96
188_R 210_C 1.087 0.96
118_A 122_K 1.082 0.96
9_F 12_Q 1.074 0.95
185_R 221_A 1.062 0.95
150_E 209_K 1.057 0.95
150_E 191_Y 1.038 0.94
25_F 31_F 1.016 0.93
157_D 160_E 1.011 0.93
219_I 223_K 1.01 0.93
226_Y 233_Y 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3gbgA10.95581000.194Contact Map0.629
1bl0A10.4941000.421Contact Map0.738
3oouA10.42571000.423Contact Map0.78
3oioA10.44581000.426Contact Map0.787
3mn2A20.421799.90.429Contact Map0.755
3w6vA10.578399.90.435Contact Map0.763
2k9sA10.421799.90.438Contact Map0.542
3mklA20.477999.90.438Contact Map0.796
3lsgA50.405699.90.444Contact Map0.875
4fe7A10.899699.90.449Contact Map0.773

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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