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3MG1 - DNA-3-methyladenine glycosylase 1
UniProt: P05100 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10986
Length: 187 (184)
Sequences: 1317
Seq/Len: 7.16

3MG1
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
61_H 71_M 4.594 1.00
143_D 159_T 3.836 1.00
75_D 78_R 3.551 1.00
26_T 113_V 3.488 1.00
15_A 19_N 2.94 1.00
115_F 148_A 2.783 1.00
55_N 84_G 2.613 1.00
40_Q 56_Y 2.429 1.00
49_V 86_I 2.404 1.00
72_Q 75_D 2.323 1.00
76_V 96_I 2.29 1.00
138_S 143_D 2.284 1.00
52_K 86_I 2.205 1.00
66_V 103_L 2.203 1.00
97_G 155_K 2.185 1.00
89_R 93_Q 2.119 1.00
20_E 53_R 2.025 1.00
166_M 171_L 1.891 1.00
28_S 111_P 1.844 1.00
47_I 51_K 1.842 1.00
13_Y 47_I 1.834 1.00
23_V 181_C 1.825 1.00
65_P 103_L 1.767 1.00
145_L 162_C 1.731 1.00
139_T 172_V 1.675 1.00
61_H 75_D 1.673 1.00
33_E 53_R 1.664 1.00
33_E 57_R 1.661 1.00
148_A 152_R 1.653 1.00
102_Y 112_F 1.629 1.00
36_C 95_I 1.629 1.00
34_M 169_C 1.602 1.00
138_S 159_T 1.594 1.00
40_Q 95_I 1.562 1.00
76_V 93_Q 1.556 1.00
73_E 93_Q 1.554 1.00
101_A 104_Q 1.544 1.00
58_A 82_D 1.542 1.00
80_V 92_I 1.534 0.99
167_Q 174_D 1.511 0.99
71_M 75_D 1.504 0.99
66_V 106_E 1.494 0.99
25_E 30_K 1.49 0.99
7_V 13_Y 1.488 0.99
166_M 172_V 1.474 0.99
108_N 152_R 1.467 0.99
20_E 33_E 1.454 0.99
5_G 176_V 1.437 0.99
4_C 17_H 1.428 0.99
141_A 144_A 1.406 0.99
119_F 148_A 1.383 0.99
141_A 145_L 1.372 0.99
79_L 85_I 1.351 0.98
109_G 152_R 1.342 0.98
131_T 134_E 1.339 0.98
94_A 155_K 1.331 0.98
135_I 176_V 1.325 0.98
97_G 101_A 1.315 0.98
82_D 87_R 1.302 0.98
34_M 38_E 1.269 0.97
177_V 182_Y 1.256 0.97
54_E 57_R 1.248 0.97
73_E 96_I 1.223 0.96
55_N 58_A 1.218 0.96
60_F 95_I 1.217 0.96
140_S 143_D 1.216 0.96
120_V 124_P 1.213 0.96
55_N 59_C 1.202 0.96
5_G 132_L 1.201 0.96
58_A 84_G 1.2 0.96
17_H 179_C 1.2 0.96
39_G 157_V 1.195 0.96
4_C 179_C 1.187 0.96
68_V 71_M 1.178 0.95
11_P 15_A 1.172 0.95
24_P 117_W 1.157 0.95
104_Q 107_Q 1.152 0.95
29_K 64_D 1.152 0.95
146_S 157_V 1.143 0.94
25_E 34_M 1.132 0.94
115_F 119_F 1.12 0.93
61_H 67_K 1.106 0.93
116_V 169_C 1.102 0.93
175_H 179_C 1.089 0.92
130_T 134_E 1.088 0.92
30_K 34_M 1.087 0.92
73_E 77_E 1.081 0.92
90_G 93_Q 1.073 0.91
165_F 169_C 1.058 0.91
10_D 51_K 1.047 0.90
120_V 171_L 1.046 0.90
109_G 148_A 1.033 0.89
28_S 110_E 1.032 0.89
65_P 102_Y 1.027 0.89
3_R 18_D 1.023 0.89
56_Y 95_I 1.014 0.88
39_G 161_I 1.013 0.88
10_D 47_I 1.01 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jg6A10.99471000.006Contact Map0.779
2ofkA20.97861000.023Contact Map0.784
3n0uA30.786195.50.925Contact Map0.603
1kg2A10.770189.70.939Contact Map0.524
1ornA10.780786.50.942Contact Map0.537
1keaA10.786186.50.942Contact Map0.587
2abkA10.775485.90.943Contact Map0.496
1pu6A20.764785.40.943Contact Map0.507
3fspA10.786183.60.945Contact Map0.51
3fhgA10.818279.30.947Contact Map0.536

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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