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AROD - 3-dehydroquinate dehydratase
UniProt: P05194 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10076
Length: 252 (251)
Sequences: 711
Seq/Len: 2.83

AROD
Paralog alert: 0.04 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
144_D 147_K 2.951 1.00
78_L 139_V 2.619 1.00
188_T 202_T 2.373 1.00
226_G 242_L 2.264 1.00
154_I 171_I 2.02 1.00
175_P 208_T 1.964 0.99
225_F 232_S 1.926 0.99
145_F 205_M 1.919 0.99
175_P 204_S 1.889 0.99
105_I 131_A 1.88 0.99
41_D 75_K 1.879 0.99
19_I 223_A 1.861 0.99
143_H 205_M 1.858 0.99
143_H 236_Q 1.781 0.99
233_A 236_Q 1.768 0.99
181_V 212_S 1.746 0.98
7_K 69_R 1.724 0.98
172_A 203_M 1.718 0.98
184_L 212_S 1.704 0.98
241_D 244_T 1.653 0.98
175_P 181_V 1.646 0.98
10_V 13_T 1.63 0.97
93_S 96_A 1.584 0.97
83_S 97_Y 1.561 0.96
49_V 79_F 1.556 0.96
173_L 184_L 1.549 0.96
213_R 233_A 1.525 0.96
184_L 202_T 1.516 0.96
145_F 174_M 1.515 0.95
184_L 204_S 1.51 0.95
188_T 203_M 1.481 0.95
11_I 168_I 1.473 0.95
143_H 233_A 1.465 0.94
112_M 168_I 1.464 0.94
5_T 10_V 1.452 0.94
216_G 221_S 1.451 0.94
3_T 10_V 1.441 0.94
79_F 104_A 1.43 0.93
204_S 212_S 1.429 0.93
143_H 213_R 1.427 0.93
181_V 204_S 1.416 0.93
205_M 233_A 1.416 0.93
6_V 11_I 1.415 0.93
87_G 116_E 1.41 0.93
112_M 139_V 1.405 0.92
76_P 168_I 1.398 0.92
114_D 143_H 1.387 0.92
102_R 126_E 1.359 0.91
104_A 113_I 1.357 0.91
6_V 112_M 1.354 0.91
201_I 223_A 1.353 0.91
79_F 110_V 1.339 0.90
205_M 213_R 1.329 0.89
213_R 236_Q 1.328 0.89
172_A 175_P 1.327 0.89
115_L 127_T 1.319 0.89
80_T 143_H 1.317 0.89
88_G 116_E 1.311 0.89
116_E 143_H 1.289 0.87
102_R 130_Y 1.283 0.87
162_Q 191_M 1.28 0.87
81_F 90_Q 1.279 0.87
83_S 86_E 1.252 0.85
94_T 98_I 1.232 0.84
217_E 250_H 1.228 0.84
45_L 72_M 1.223 0.83
181_V 187_A 1.211 0.83
205_M 236_Q 1.211 0.83
214_L 237_I 1.206 0.82
78_L 112_M 1.206 0.82
172_A 181_V 1.205 0.82
172_A 187_A 1.203 0.82
48_R 80_T 1.197 0.82
153_E 156_A 1.191 0.81
145_F 172_A 1.185 0.81
68_L 212_S 1.181 0.80
26_D 29_S 1.168 0.79
80_T 116_E 1.164 0.79
137_K 167_D 1.155 0.78
185_L 219_F 1.143 0.77
131_A 136_V 1.131 0.76
21_S 30_V 1.131 0.76
188_T 200_I 1.125 0.76
205_M 234_P 1.124 0.76
159_R 195_Y 1.122 0.75
175_P 180_D 1.12 0.75
151_A 190_E 1.116 0.75
84_A 91_A 1.11 0.74
94_T 119_T 1.107 0.74
81_F 100_L 1.098 0.73
80_T 213_R 1.098 0.73
34_A 71_T 1.088 0.72
169_P 198_R 1.088 0.72
154_I 173_L 1.084 0.72
5_T 8_D 1.071 0.71
80_T 205_M 1.071 0.71
27_I 31_K 1.07 0.70
116_E 234_P 1.066 0.70
82_R 116_E 1.065 0.70
88_G 114_D 1.064 0.70
23_M 232_S 1.062 0.70
17_K 97_Y 1.06 0.69
117_L 140_M 1.055 0.69
132_H 138_V 1.049 0.68
142_N 157_R 1.047 0.68
26_D 53_A 1.046 0.68
86_E 118_F 1.041 0.67
47_W 65_A 1.038 0.67
213_R 224_T 1.03 0.66
162_Q 198_R 1.029 0.66
32_S 106_D 1.028 0.66
22_L 30_V 1.023 0.65
205_M 235_G 1.018 0.65
27_I 52_Y 1.017 0.65
31_K 113_I 1.015 0.65
103_A 160_K 1.015 0.65
238_S 241_D 1.014 0.64
33_E 229_K 1.013 0.64
7_K 73_P 1.011 0.64
42_F 228_V 1.009 0.64
173_L 202_T 1.007 0.64
191_M 195_Y 1.007 0.64
214_L 221_S 1.006 0.64
245_V 248_I 1.006 0.64
172_A 205_M 1.001 0.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3o1nA211000.04Contact Map0.691
4h3dA411000.043Contact Map0.666
3l9cA20.94841000.138Contact Map0.639
2yr1A20.99211000.15Contact Map0.689
1sflA20.93651000.155Contact Map0.627
2oczA10.90481000.163Contact Map0.618
2o7sA10.90871000.195Contact Map0.596
2egzA20.8691000.213Contact Map0.571
2ox1A40.77381000.245Contact Map0.596
3f4wA20.809598.20.869Contact Map0.547

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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