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APAH - Bis(5'-nucleosyl)-tetraphosphatase [symmetrical]
UniProt: P05637 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10048
Length: 280 (268)
Sequences: 796
Seq/Len: 2.97

APAH
Paralog alert: 0.09 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
44_G 47_D 5.464 1.00
14_D 44_G 3.863 1.00
257_R 260_D 3.049 1.00
23_V 255_C 2.843 1.00
50_R 92_A 2.648 1.00
9_V 16_L 2.54 1.00
34_L 52_V 2.534 1.00
128_D 131_T 2.523 1.00
245_T 254_T 2.406 1.00
39_V 70_L 2.31 1.00
9_V 48_V 2.307 1.00
33_W 118_M 2.197 1.00
50_R 94_D 2.11 1.00
13_Y 17_I 2.094 1.00
25_F 30_D 2.065 1.00
4_Y 23_V 2.01 1.00
55_L 59_V 1.974 1.00
33_W 109_Q 1.959 1.00
87_T 91_E 1.955 1.00
16_L 51_Y 1.936 0.99
257_R 264_F 1.902 0.99
241_Y 256_L 1.849 0.99
74_F 99_L 1.833 0.99
132_A 180_F 1.813 0.99
50_R 98_L 1.784 0.99
169_G 172_R 1.771 0.99
13_Y 47_D 1.77 0.99
108_L 132_A 1.753 0.99
56_G 59_V 1.742 0.99
19_L 255_C 1.732 0.99
60_R 109_Q 1.724 0.98
138_D 172_R 1.722 0.98
32_L 55_L 1.721 0.98
108_L 117_V 1.719 0.98
151_F 177_T 1.718 0.98
63_L 68_L 1.707 0.98
53_K 97_E 1.695 0.98
35_T 62_V 1.689 0.98
169_G 176_I 1.687 0.98
34_L 59_V 1.681 0.98
16_L 34_L 1.671 0.98
6_I 255_C 1.641 0.98
52_V 59_V 1.592 0.97
222_S 241_Y 1.574 0.97
185_F 203_A 1.569 0.97
252_T 265_V 1.555 0.97
31_T 60_R 1.505 0.96
123_I 132_A 1.475 0.95
40_A 85_R 1.466 0.95
4_Y 30_D 1.412 0.93
9_V 34_L 1.388 0.93
225_F 240_I 1.378 0.92
75_A 148_Y 1.369 0.92
13_Y 51_Y 1.367 0.92
4_Y 25_F 1.366 0.92
5_L 118_M 1.361 0.92
12_C 248_C 1.358 0.91
6_I 23_V 1.346 0.91
53_K 56_G 1.345 0.91
138_D 176_I 1.329 0.90
47_D 88_P 1.326 0.90
175_F 179_A 1.324 0.90
116_L 258_W 1.318 0.90
229_A 248_C 1.301 0.89
193_D 207_L 1.295 0.89
26_T 30_D 1.294 0.89
260_D 264_F 1.289 0.88
92_A 98_L 1.287 0.88
3_T 259_E 1.279 0.88
69_H 156_Y 1.275 0.88
39_V 67_D 1.271 0.87
97_E 100_N 1.262 0.87
15_E 268_S 1.259 0.87
137_R 140_E 1.258 0.87
224_A 256_L 1.257 0.87
6_I 34_L 1.257 0.87
68_L 155_M 1.253 0.86
108_L 133_K 1.228 0.85
96_D 100_N 1.201 0.83
17_I 51_Y 1.198 0.83
173_L 177_T 1.192 0.82
17_I 21_H 1.184 0.82
47_D 51_Y 1.181 0.82
25_F 58_S 1.178 0.81
161_N 191_Q 1.172 0.81
41_R 228_W 1.17 0.81
103_R 148_Y 1.168 0.81
5_L 258_W 1.167 0.81
26_T 29_K 1.165 0.80
50_R 97_E 1.164 0.80
139_V 177_T 1.152 0.79
222_S 261_K 1.145 0.79
124_T 175_F 1.137 0.78
38_L 48_V 1.136 0.78
9_V 52_V 1.136 0.78
148_Y 152_L 1.132 0.78
31_T 57_D 1.114 0.76
61_L 105_Q 1.077 0.73
252_T 267_P 1.076 0.72
138_D 169_G 1.074 0.72
60_R 105_Q 1.071 0.72
24_E 28_G 1.062 0.71
135_C 176_I 1.059 0.71
68_L 181_T 1.055 0.70
94_D 98_L 1.053 0.70
160_P 174_R 1.047 0.69
124_T 179_A 1.04 0.69
40_A 229_A 1.036 0.68
142_V 173_L 1.033 0.68
136_A 140_E 1.024 0.67
52_V 55_L 1.021 0.67
5_L 116_L 1.02 0.67
254_T 263_Y 1.019 0.66
10_H 248_C 1.007 0.65
16_L 59_V 1 0.64
92_A 190_G 1 0.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2dfjA211000.334Contact Map0.812
2qjcA10.81071000.545Contact Map0.74
4j6oA20.81000.618Contact Map0.808
2z72A10.85711000.636Contact Map0.741
3icfA20.85361000.696Contact Map0.644
1g5bA30.71071000.697Contact Map0.765
1fjmA20.851000.7Contact Map0.679
3e7aA20.828699.90.707Contact Map0.685
4il1A40.871499.90.708Contact Map0.672
4i5lC20.853699.90.71Contact Map0.693

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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