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BGLR - Beta-glucuronidase
UniProt: P05804 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11055
Length: 603 (586)
Sequences: 2281
Seq/Len: 3.89

BGLR
Paralog alert: 0.42 [within 20: 0.06] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
16_D 173_S 5.537 1.00
325_S 547_Q 4.409 1.00
268_R 343_E 4.065 1.00
91_V 170_I 4.01 1.00
105_M 116_A 3.968 1.00
104_V 121_Y 3.911 1.00
88_F 132_V 3.789 1.00
99_V 130_I 3.713 1.00
312_V 343_E 3.653 1.00
83_R 117_D 3.559 1.00
213_S 255_T 3.396 1.00
240_H 248_Y 3.375 1.00
96_K 103_E 3.294 1.00
72_E 127_S 3.273 1.00
396_I 432_T 3.226 1.00
99_V 104_V 3.213 1.00
20_A 44_A 3.117 1.00
326_Y 346_I 3.104 1.00
213_S 257_K 3.042 1.00
216_L 269_V 3.034 1.00
70_Q 129_R 2.923 1.00
240_H 246_E 2.91 1.00
82_Q 178_T 2.89 1.00
100_N 128_V 2.856 1.00
308_N 336_E 2.774 1.00
82_Q 180_P 2.763 1.00
91_V 95_G 2.701 1.00
215_E 255_T 2.664 1.00
397_A 435_L 2.578 1.00
407_M 462_V 2.568 1.00
243_Q 246_E 2.562 1.00
433_R 441_I 2.45 1.00
91_V 134_V 2.446 1.00
99_V 118_V 2.435 1.00
84_I 122_V 2.427 1.00
86_L 118_V 2.426 1.00
76_P 79_W 2.404 1.00
88_F 91_V 2.397 1.00
86_L 97_V 2.319 1.00
219_A 248_Y 2.319 1.00
217_R 253_C 2.317 1.00
276_V 440_P 2.307 1.00
244_P 347_V 2.279 1.00
431_A 435_L 2.276 1.00
290_F 406_V 2.246 1.00
312_V 316_A 2.156 1.00
429_A 433_R 2.155 1.00
245_G 319_D 2.124 1.00
281_F 406_V 2.122 1.00
392_I 432_T 2.09 1.00
255_T 264_I 2.083 1.00
236_V 239_P 2.082 1.00
74_F 127_S 2.077 1.00
215_E 253_C 2.072 1.00
283_I 288_F 2.066 1.00
315_H 346_I 2.065 1.00
252_L 269_V 2.065 1.00
113_P 398_R 2.044 1.00
217_R 223_V 2.043 1.00
188_T 400_K 2.024 1.00
350_D 399_D 1.982 1.00
397_A 400_K 1.98 1.00
73_V 130_I 1.967 1.00
321_I 581_A 1.947 1.00
79_W 178_T 1.928 1.00
314_D 575_R 1.921 1.00
81_G 181_N 1.92 1.00
15_L 73_V 1.913 1.00
96_K 106_E 1.912 1.00
187_I 254_V 1.909 1.00
214_V 254_V 1.866 1.00
389_L 427_P 1.86 1.00
193_V 241_L 1.846 1.00
245_G 286_K 1.844 1.00
342_D 402_H 1.833 1.00
107_H 114_F 1.826 1.00
393_K 431_A 1.821 1.00
350_D 395_L 1.814 1.00
326_Y 337_M 1.793 0.99
84_I 178_T 1.786 0.99
46_A 49_G 1.778 0.99
216_L 252_L 1.778 0.99
572_T 576_K 1.777 0.99
215_E 223_V 1.746 0.99
96_K 133_C 1.737 0.99
214_V 252_L 1.733 0.99
225_A 234_L 1.724 0.99
218_D 222_Q 1.723 0.99
253_C 264_I 1.721 0.99
251_E 268_R 1.701 0.99
216_L 236_V 1.694 0.99
70_Q 131_T 1.69 0.99
426_A 430_E 1.684 0.99
313_H 316_A 1.68 0.99
430_E 434_K 1.678 0.99
75_I 122_V 1.667 0.99
85_V 117_D 1.654 0.99
89_D 175_M 1.633 0.99
299_A 310_L 1.627 0.99
102_Q 121_Y 1.627 0.99
434_K 437_P 1.618 0.99
315_H 344_H 1.595 0.98
132_V 174_V 1.582 0.98
531_D 535_R 1.58 0.98
20_A 70_Q 1.579 0.98
307_D 310_L 1.573 0.98
18_L 44_A 1.57 0.98
429_A 441_I 1.568 0.98
97_V 132_V 1.567 0.98
302_R 305_G 1.563 0.98
83_R 181_N 1.552 0.98
342_D 404_S 1.551 0.98
72_E 129_R 1.549 0.98
95_G 107_H 1.548 0.98
392_I 428_L 1.526 0.98
277_K 282_L 1.525 0.98
273_S 285_H 1.52 0.98
283_I 347_V 1.517 0.98
91_V 132_V 1.515 0.98
316_A 320_W 1.512 0.98
243_Q 286_K 1.508 0.98
341_A 348_V 1.505 0.97
189_V 267_L 1.494 0.97
258_S 261_E 1.492 0.97
215_E 226_T 1.49 0.97
223_V 226_T 1.488 0.97
186_D 400_K 1.486 0.97
203_D 233_T 1.486 0.97
236_V 271_I 1.456 0.97
192_H 273_S 1.454 0.97
253_C 266_P 1.454 0.97
315_H 337_M 1.452 0.97
245_G 288_F 1.452 0.97
12_I 175_M 1.446 0.97
433_R 461_D 1.445 0.97
79_W 84_I 1.435 0.96
315_H 341_A 1.434 0.96
194_A 241_L 1.429 0.96
550_N 554_F 1.415 0.96
302_R 307_D 1.408 0.96
112_T 394_E 1.406 0.96
293_F 323_A 1.377 0.95
251_E 266_P 1.371 0.95
189_V 269_V 1.366 0.95
184_V 256_A 1.365 0.95
389_L 431_A 1.357 0.95
66_N 133_C 1.347 0.94
87_R 177_Y 1.345 0.94
274_V 281_F 1.338 0.94
83_R 183_W 1.337 0.94
33_R 36_E 1.335 0.94
347_V 406_V 1.334 0.94
21_F 65_G 1.334 0.94
577_P 581_A 1.328 0.94
213_S 226_T 1.317 0.93
87_R 115_E 1.311 0.93
94_Y 108_Q 1.298 0.93
340_W 344_H 1.293 0.93
211_D 257_K 1.285 0.92
83_R 120_P 1.285 0.92
244_P 288_F 1.282 0.92
350_D 398_R 1.28 0.92
83_R 119_T 1.274 0.92
211_D 228_Q 1.27 0.92
550_N 568_K 1.266 0.92
20_A 131_T 1.264 0.91
436_D 439_R 1.263 0.91
275_A 282_L 1.246 0.91
15_L 71_R 1.239 0.90
410_I 432_T 1.235 0.90
274_V 406_V 1.232 0.90
202_V 271_I 1.229 0.90
218_D 248_Y 1.228 0.90
200_A 271_I 1.228 0.90
201_S 233_T 1.227 0.90
98_W 103_E 1.226 0.90
281_F 290_F 1.224 0.90
329_S 333_Y 1.22 0.89
501_I 544_V 1.218 0.89
316_A 344_H 1.21 0.89
197_C 241_L 1.209 0.89
302_R 310_L 1.208 0.89
189_V 252_L 1.208 0.89
107_H 394_E 1.207 0.89
14_K 173_S 1.205 0.89
56_A 59_D 1.202 0.88
68_W 131_T 1.2 0.88
338_L 348_V 1.193 0.88
338_L 402_H 1.192 0.88
213_S 228_Q 1.187 0.88
81_G 84_I 1.187 0.88
113_P 399_D 1.187 0.88
90_A 171_H 1.177 0.87
224_V 236_V 1.175 0.87
295_R 333_Y 1.171 0.87
318_M 323_A 1.169 0.87
308_N 312_V 1.164 0.86
85_V 183_W 1.156 0.86
72_E 126_K 1.152 0.85
104_V 116_A 1.15 0.85
348_V 404_S 1.15 0.85
333_Y 338_L 1.148 0.85
30_I 133_C 1.146 0.85
191_T 200_A 1.143 0.85
35_W 46_A 1.14 0.85
442_T 464_C 1.135 0.84
338_L 399_D 1.134 0.84
200_A 239_P 1.132 0.84
71_R 130_I 1.13 0.84
218_D 224_V 1.126 0.84
187_I 267_L 1.125 0.84
341_A 346_I 1.124 0.84
582_F 585_Q 1.119 0.83
570_I 581_A 1.119 0.83
187_I 265_Y 1.118 0.83
552_A 575_R 1.117 0.83
295_R 314_D 1.113 0.83
407_M 440_P 1.113 0.83
218_D 251_E 1.112 0.83
109_G 353_A 1.112 0.83
584_L 588_W 1.11 0.82
45_I 49_G 1.109 0.82
193_V 197_C 1.105 0.82
73_V 128_V 1.1 0.82
11_E 82_Q 1.098 0.82
309_V 312_V 1.097 0.81
103_E 106_E 1.095 0.81
123_I 126_K 1.092 0.81
85_V 115_E 1.091 0.81
95_G 132_V 1.091 0.81
163_D 331_Y 1.09 0.81
132_V 170_I 1.087 0.81
328_T 333_Y 1.085 0.80
549_W 553_D 1.084 0.80
73_V 100_N 1.083 0.80
296_H 331_Y 1.077 0.80
506_G 520_M 1.074 0.80
85_V 179_T 1.074 0.80
80_A 124_A 1.071 0.79
118_V 122_V 1.071 0.79
275_A 285_H 1.068 0.79
194_A 198_N 1.065 0.79
68_W 133_C 1.064 0.79
390_Q 394_E 1.059 0.78
34_W 39_L 1.057 0.78
308_N 340_W 1.053 0.78
219_A 240_H 1.051 0.77
393_K 435_L 1.051 0.77
514_H 517_Y 1.051 0.77
352_T 395_L 1.05 0.77
311_M 337_M 1.049 0.77
400_K 435_L 1.043 0.77
586_K 589_T 1.041 0.76
288_F 347_V 1.038 0.76
268_R 339_D 1.038 0.76
308_N 339_D 1.037 0.76
258_S 262_C 1.036 0.76
321_I 582_F 1.033 0.76
193_V 285_H 1.033 0.76
108_Q 387_A 1.031 0.76
291_T 590_G 1.027 0.75
99_V 121_Y 1.024 0.75
18_L 46_A 1.018 0.74
299_A 307_D 1.017 0.74
10_R 263_D 1.013 0.74
134_V 170_I 1.011 0.73
282_L 287_P 1.007 0.73
76_P 178_T 1.006 0.73
338_L 350_D 1.004 0.73
393_K 397_A 1.002 0.73
221_Q 224_V 1.002 0.73
554_F 568_K 1.001 0.72
199_H 237_V 1 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3lpfA20.99831000.231Contact Map0.719
3hn3A40.95521000.281Contact Map0.776
3fn9A40.90881000.283Contact Map0.789
3cmgA10.90381000.286Contact Map0.775
1jz7A40.89221000.29Contact Map0.817
3gm8A10.89551000.295Contact Map0.805
3obaA40.90381000.308Contact Map0.784
3bgaA20.87891000.314Contact Map0.786
1yq2A60.89391000.324Contact Map0.77
2je8A20.89051000.4Contact Map0.689

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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