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ADA - Bifunctional transcriptional activator/DNA repair enzyme Ada
UniProt: P06134 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10029
Length: 354 (345)
Sequences: 424
Seq/Len: 1.23

ADA
Paralog alert: 0.12 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
326_R 332_S 3.293 1.00
30_A 55_Y 3.198 1.00
42_C 72_C 2.839 1.00
69_C 72_C 2.828 1.00
42_C 69_C 2.798 1.00
117_H 127_T 2.752 1.00
53_S 66_F 2.738 1.00
193_L 223_I 2.575 1.00
195_D 200_R 2.432 0.99
288_V 293_L 2.342 0.99
90_A 116_L 2.337 0.99
11_Q 49_R 2.315 0.99
9_D 49_R 2.255 0.99
189_V 211_C 2.249 0.99
69_C 74_P 2.137 0.98
42_C 74_P 2.103 0.98
183_G 231_P 2.09 0.98
14_Q 18_A 2.023 0.97
188_A 234_D 1.895 0.96
24_D 41_S 1.857 0.95
200_R 219_D 1.75 0.92
307_A 311_A 1.733 0.92
56_A 60_E 1.715 0.91
291_Q 327_G 1.678 0.90
308_S 311_A 1.659 0.89
282_I 293_L 1.645 0.89
343_Q 347_R 1.63 0.88
274_Q 299_K 1.588 0.86
153_S 157_A 1.561 0.85
73_Q 76_K 1.523 0.83
28_V 58_A 1.521 0.83
316_A 319_I 1.521 0.83
149_S 152_T 1.496 0.82
205_E 245_H 1.489 0.81
39_R 74_P 1.488 0.81
32_R 53_S 1.484 0.81
37_F 62_L 1.468 0.80
15_S 45_R 1.464 0.80
220_A 224_S 1.422 0.77
189_V 206_S 1.409 0.76
191_Y 237_P 1.389 0.75
57_N 60_E 1.383 0.74
95_E 135_W 1.367 0.73
39_R 150_V 1.352 0.72
343_Q 346_R 1.35 0.72
196_C 319_I 1.33 0.70
25_G 42_C 1.329 0.70
282_I 288_V 1.322 0.69
151_T 174_G 1.315 0.69
121_K 127_T 1.302 0.68
308_S 312_A 1.295 0.67
190_R 236_A 1.292 0.67
59_S 77_A 1.282 0.66
175_M 183_G 1.28 0.66
227_Q 237_P 1.27 0.65
264_L 319_I 1.268 0.65
213_I 318_I 1.258 0.64
94_L 292_Q 1.254 0.63
27_F 40_P 1.254 0.63
112_S 115_H 1.242 0.62
293_L 311_A 1.241 0.62
140_L 165_Y 1.237 0.62
129_K 133_Q 1.227 0.61
47_A 69_C 1.225 0.61
223_I 227_Q 1.224 0.61
42_C 47_A 1.219 0.60
102_L 272_Q 1.216 0.60
43_R 48_L 1.211 0.59
281_T 296_A 1.206 0.59
289_S 307_A 1.203 0.59
44_A 55_Y 1.193 0.58
194_A 201_C 1.185 0.57
150_V 153_S 1.185 0.57
49_R 111_M 1.184 0.57
30_A 66_F 1.184 0.57
29_F 44_A 1.18 0.56
87_I 325_V 1.177 0.56
8_T 11_Q 1.164 0.55
266_I 319_I 1.16 0.54
17_L 49_R 1.158 0.54
147_G 220_A 1.152 0.54
266_I 273_Q 1.146 0.53
10_D 49_R 1.14 0.52
22_N 26_E 1.137 0.52
25_G 74_P 1.136 0.52
197_E 253_L 1.13 0.51
292_Q 297_I 1.129 0.51
117_H 130_A 1.126 0.51
224_S 228_Q 1.125 0.51
282_I 331_L 1.119 0.50
186_N 223_I 1.118 0.50
255_Q 258_T 1.115 0.50
159_F 253_L 1.115 0.50
55_Y 58_A 1.114 0.50
117_H 124_T 1.114 0.50
222_L 310_C 1.112 0.50
160_P 164_S 1.104 0.49
15_S 44_A 1.104 0.49
25_G 69_C 1.102 0.49
119_L 289_S 1.099 0.48
25_G 72_C 1.098 0.48
141_R 159_F 1.093 0.48
292_Q 295_N 1.09 0.48
202_L 315_L 1.086 0.47
13_W 49_R 1.086 0.47
188_A 236_A 1.085 0.47
263_P 344_L 1.08 0.47
22_N 32_R 1.078 0.46
85_D 331_L 1.076 0.46
122_A 195_D 1.076 0.46
201_C 237_P 1.076 0.46
251_A 256_R 1.075 0.46
288_V 296_A 1.072 0.46
171_E 240_L 1.07 0.46
108_Q 150_V 1.069 0.45
47_A 72_C 1.067 0.45
63_A 142_E 1.067 0.45
207_E 277_Q 1.063 0.45
28_V 57_N 1.062 0.45
333_G 345_L 1.06 0.45
164_S 167_R 1.059 0.45
148_E 153_S 1.056 0.44
114_F 127_T 1.055 0.44
94_L 269_T 1.054 0.44
44_A 311_A 1.053 0.44
219_D 237_P 1.051 0.44
218_D 221_T 1.051 0.44
162_S 176_T 1.05 0.44
30_A 99_P 1.05 0.44
34_T 42_C 1.05 0.44
47_A 154_I 1.046 0.43
59_S 152_T 1.045 0.43
118_R 121_K 1.042 0.43
105_L 141_R 1.041 0.43
74_P 229_M 1.04 0.43
196_C 232_A 1.038 0.42
310_C 335_R 1.036 0.42
219_D 227_Q 1.035 0.42
66_F 248_E 1.032 0.42
17_L 46_H 1.026 0.41
26_E 32_R 1.022 0.41
198_L 317_I 1.022 0.41
222_L 335_R 1.022 0.41
115_H 118_R 1.022 0.41
212_A 335_R 1.02 0.41
116_L 319_I 1.02 0.41
244_Q 248_E 1.019 0.41
124_T 214_L 1.016 0.40
36_I 82_H 1.011 0.40
103_E 113_P 1.006 0.39
32_R 55_Y 1.005 0.39
57_N 100_V 1.004 0.39
60_E 303_V 1.003 0.39
213_I 310_C 1.002 0.39
240_L 292_Q 1 0.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1sfeA10.50851000.621Contact Map0.455
4bhbA10.44921000.679Contact Map0.394
3l00A10.49151000.679Contact Map0.49
1eh6A10.48311000.682Contact Map0.457
1wrjA10.42661000.692Contact Map0.441
1u8bA10.37571000.725Contact Map0.53
1mgtA10.44071000.733Contact Map0.377
2g7hA10.41811000.733Contact Map0.296
3gvaA20.25141000.782Contact Map0.5
2kifA10.24581000.782Contact Map0.386

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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