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BTUD - Vitamin B12 import ATP-binding protein BtuD
UniProt: P06611 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10128
Length: 249 (221)
Sequences: 72243
Seq/Len: 326.89

BTUD
Paralog alert: 0.94 [within 20: 0.85] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
30_H 200_A 3.198 1.00
6_Q 22_E 3.189 1.00
27_E 202_R 3.161 1.00
9_D 18_P 2.95 1.00
119_K 122_R 2.938 1.00
8_Q 55_S 2.921 1.00
55_S 62_P 2.9 1.00
29_L 204_W 2.795 1.00
6_Q 57_Q 2.686 1.00
112_G 117_D 2.624 1.00
74_H 147_Q 2.579 1.00
17_G 210_K 2.564 1.00
24_R 27_E 2.523 1.00
202_R 214_S 2.514 1.00
11_A 18_P 2.363 1.00
7_L 10_V 2.302 1.00
12_E 45_R 2.271 1.00
106_L 144_I 2.158 1.00
11_A 53_K 2.066 1.00
215_G 219_E 2.053 1.00
216_R 219_E 2.052 1.00
90_V 127_L 2.042 1.00
59_A 147_Q 2.014 1.00
8_Q 57_Q 1.982 1.00
108_N 120_L 1.88 1.00
111_A 120_L 1.867 1.00
25_A 147_Q 1.842 1.00
204_W 211_M 1.838 1.00
91_W 120_L 1.837 1.00
91_W 121_G 1.808 1.00
144_I 184_L 1.807 1.00
113_A 178_A 1.791 1.00
27_E 201_H 1.748 1.00
9_D 20_S 1.74 1.00
204_W 214_S 1.684 1.00
12_E 52_G 1.657 1.00
109_D 113_A 1.653 1.00
91_W 108_N 1.63 1.00
13_S 52_G 1.612 1.00
43_L 189_S 1.586 1.00
91_W 107_L 1.547 1.00
122_R 126_Q 1.531 1.00
106_L 109_D 1.525 1.00
80_Q 129_G 1.494 1.00
43_L 156_L 1.49 1.00
113_A 182_Q 1.474 1.00
91_W 95_T 1.472 1.00
23_V 29_L 1.457 1.00
21_G 204_W 1.422 1.00
8_Q 22_E 1.42 1.00
215_G 220_V 1.413 1.00
11_A 17_G 1.376 0.99
16_L 45_R 1.375 0.99
7_L 46_M 1.374 0.99
12_E 50_T 1.364 0.99
57_Q 62_P 1.346 0.99
117_D 120_L 1.328 0.99
7_L 21_G 1.326 0.99
104_T 108_N 1.325 0.99
178_A 181_Q 1.307 0.99
157_L 176_L 1.305 0.99
88_T 92_H 1.303 0.99
108_N 112_G 1.299 0.99
89_P 92_H 1.297 0.99
105_E 109_D 1.29 0.99
95_T 107_L 1.268 0.99
59_A 74_H 1.263 0.99
93_Y 139_A 1.261 0.99
12_E 41_T 1.258 0.99
180_C 201_H 1.257 0.99
8_Q 20_S 1.226 0.98
94_L 142_L 1.214 0.98
178_A 182_Q 1.187 0.98
119_K 131_E 1.185 0.98
190_S 196_T 1.176 0.98
29_L 214_S 1.174 0.98
24_R 202_R 1.17 0.97
42_L 206_L 1.165 0.97
67_S 70_K 1.165 0.97
106_L 110_V 1.158 0.97
95_T 103_R 1.153 0.97
108_N 117_D 1.152 0.97
4_V 59_A 1.148 0.97
90_V 135_V 1.147 0.97
47_A 77_Y 1.124 0.97
44_A 50_T 1.117 0.96
28_I 186_I 1.114 0.96
114_L 138_A 1.1 0.96
28_I 180_C 1.1 0.96
91_W 104_T 1.099 0.96
62_P 65_A 1.093 0.96
29_L 202_R 1.088 0.96
173_D 195_H 1.087 0.96
110_V 142_L 1.082 0.96
179_L 184_L 1.08 0.95
169_Q 195_H 1.069 0.95
7_L 42_L 1.067 0.95
94_L 111_A 1.064 0.95
31_L 42_L 1.055 0.95
109_D 112_G 1.053 0.95
111_A 116_L 1.048 0.94
207_K 212_L 1.029 0.94
89_P 93_Y 1.024 0.93
175_I 178_A 1.024 0.93
9_D 53_K 1.023 0.93
45_R 56_I 1.023 0.93
46_M 187_V 1.021 0.93
25_A 59_A 1.02 0.93
127_L 135_V 1.017 0.93
19_L 42_L 1.016 0.93
7_L 56_I 1.011 0.93
110_V 138_A 1.008 0.93
115_A 171_A 1.008 0.93
171_A 174_K 1.007 0.93
95_T 104_T 1.001 0.92
147_Q 184_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4hziA20.97191000.043Contact Map0.882
3tuiC40.97191000.043Contact Map0.864
3fvqA20.97191000.045Contact Map0.78
1oxxK10.96791000.046Contact Map0.808
2qi9C20.9961000.048Contact Map0.732
2it1A20.95981000.049Contact Map0.859
1v43A10.95981000.051Contact Map0.817
2yyzA10.95981000.052Contact Map0.81
2oljA20.91161000.052Contact Map0.884
1g29120.96791000.052Contact Map0.889

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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