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BIRA - Bifunctional protein BirA
UniProt: P06709 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10123
Length: 321 (312)
Sequences: 1148
Seq/Len: 3.68

BIRA
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
290_R 301_E 3.726 1.00
159_E 264_R 3.502 1.00
87_I 93_Y 3.129 1.00
159_E 245_E 3.095 1.00
133_L 239_A 2.928 1.00
110_E 235_R 2.812 1.00
131_L 239_A 2.811 1.00
86_V 111_Y 2.684 1.00
266_E 291_G 2.644 1.00
170_R 270_N 2.592 1.00
134_S 202_V 2.581 1.00
93_Y 96_D 2.562 1.00
94_L 136_F 2.451 1.00
108_I 239_A 2.384 1.00
125_S 132_Y 2.327 1.00
23_E 27_E 2.258 1.00
163_K 245_E 2.224 1.00
106_A 135_M 2.208 1.00
84_L 87_I 2.206 1.00
154_G 171_V 2.157 1.00
75_Q 240_A 2.13 1.00
88_D 93_Y 2.117 1.00
293_D 297_A 2.084 1.00
158_A 268_L 2.015 1.00
51_F 59_S 1.951 1.00
157_M 185_A 1.937 1.00
291_G 299_L 1.937 1.00
41_Q 44_R 1.932 1.00
163_K 241_M 1.915 1.00
302_Q 307_K 1.903 1.00
88_D 92_Q 1.888 1.00
160_V 242_L 1.871 1.00
277_K 286_F 1.849 1.00
179_L 184_L 1.842 1.00
162_R 268_L 1.839 1.00
88_D 96_D 1.838 0.99
293_D 308_P 1.833 0.99
272_I 291_G 1.825 0.99
22_G 33_R 1.818 0.99
277_K 284_E 1.816 0.99
35_A 38_K 1.795 0.99
19_F 53_V 1.738 0.99
13_L 25_L 1.733 0.99
94_L 107_C 1.717 0.99
278_L 309_W 1.715 0.99
278_L 314_I 1.704 0.99
159_E 249_A 1.69 0.99
153_I 203_I 1.637 0.99
299_L 306_I 1.628 0.98
16_N 20_H 1.628 0.98
68_N 71_Q 1.626 0.98
271_F 289_S 1.564 0.98
262_L 266_E 1.553 0.98
149_L 201_I 1.546 0.98
33_R 38_K 1.543 0.98
123_W 174_P 1.514 0.97
106_A 243_I 1.509 0.97
302_Q 305_I 1.506 0.97
135_M 246_L 1.501 0.97
177_L 185_A 1.498 0.97
130_N 211_M 1.494 0.97
156_V 249_A 1.489 0.97
169_V 177_L 1.479 0.97
290_R 306_I 1.452 0.96
84_L 93_Y 1.442 0.96
238_L 242_L 1.411 0.95
53_V 56_K 1.408 0.95
182_R 224_I 1.4 0.95
131_L 209_M 1.396 0.95
125_S 130_N 1.394 0.95
152_V 249_A 1.384 0.95
301_E 306_I 1.364 0.94
156_V 160_V 1.36 0.94
276_V 316_L 1.348 0.94
158_A 169_V 1.339 0.93
33_R 58_Y 1.32 0.93
65_Q 234_D 1.318 0.93
10_L 39_H 1.306 0.92
225_T 228_E 1.301 0.92
160_V 164_L 1.28 0.91
115_G 125_S 1.271 0.91
22_G 58_Y 1.267 0.91
275_P 288_I 1.253 0.90
104_G 247_R 1.243 0.90
276_V 289_S 1.242 0.90
169_V 179_L 1.239 0.89
297_A 310_M 1.238 0.89
279_I 284_E 1.231 0.89
51_F 61_P 1.23 0.89
178_Y 270_N 1.227 0.89
106_A 239_A 1.227 0.89
98_I 136_F 1.225 0.89
22_G 38_K 1.217 0.88
150_S 189_V 1.216 0.88
185_A 207_I 1.214 0.88
108_I 133_L 1.213 0.88
68_N 236_N 1.198 0.87
72_I 81_V 1.193 0.87
19_F 59_S 1.19 0.87
157_M 242_L 1.186 0.87
13_L 29_L 1.176 0.86
207_I 242_L 1.176 0.86
97_R 107_C 1.165 0.85
162_R 168_K 1.158 0.85
72_I 236_N 1.158 0.85
157_M 177_L 1.149 0.84
121_R 313_E 1.148 0.84
278_L 300_L 1.145 0.84
236_N 240_A 1.138 0.83
271_F 291_G 1.135 0.83
22_G 35_A 1.134 0.83
67_L 110_E 1.132 0.83
240_A 244_R 1.127 0.82
161_L 165_G 1.12 0.82
67_L 83_V 1.094 0.80
151_L 296_G 1.091 0.80
288_I 301_E 1.086 0.79
91_N 312_G 1.086 0.79
93_Y 97_R 1.084 0.79
266_E 272_I 1.083 0.79
160_V 245_E 1.081 0.79
103_S 250_L 1.072 0.78
249_A 252_L 1.07 0.78
203_I 250_L 1.063 0.77
160_V 238_L 1.057 0.77
69_A 83_V 1.054 0.76
234_D 237_T 1.053 0.76
242_L 246_L 1.051 0.76
266_E 292_I 1.043 0.75
265_W 269_D 1.043 0.75
275_P 286_F 1.043 0.75
13_L 28_T 1.041 0.75
162_R 169_V 1.041 0.75
120_G 313_E 1.037 0.75
9_K 12_A 1.036 0.74
184_L 224_I 1.031 0.74
285_I 309_W 1.016 0.72
258_L 262_L 1.012 0.72
37_N 194_K 1.011 0.72
263_S 267_K 1.007 0.71
21_S 33_R 1.007 0.71
137_W 250_L 1.004 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1biaA111000.162Contact Map0.773
3rkxA10.9721000.175Contact Map0.814
2eayA20.71961000.347Contact Map0.888
3ruxA20.79441000.35Contact Map0.745
2dxuA20.71341000.354Contact Map0.78
2ej9A10.70721000.362Contact Map0.706
3bfmA10.7041000.476Contact Map0.693
1vqzA10.813199.90.752Contact Map0.39
2p5iA10.750899.90.783Contact Map0.429
2p0lA10.763299.60.829Contact Map0.407

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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