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ODP2 - Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
UniProt: P06959 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10025
Length: 630 (621)
Sequences: 717
Seq/Len: 1.15

ODP2
Paralog alert: 0.08 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: ODO2 ODP2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
148_E 249_E 3.853 1.00
124_L 225_M 3.83 1.00
132_E 233_A 3.544 1.00
140_V 241_V 3.532 1.00
149_V 250_V 3.482 1.00
135_Q 236_Q 3.482 1.00
126_K 227_K 3.471 1.00
134_E 235_E 3.4 1.00
142_G 243_G 3.293 1.00
174_I 275_I 3.277 1.00
146_S 247_S 3.227 1.00
136_S 237_S 3.18 1.00
139_T 240_T 3.165 1.00
119_E 220_E 2.954 1.00
138_I 239_I 2.93 1.00
113_I 214_I 2.868 1.00
431_K 581_E 2.834 1.00
133_A 234_A 2.802 1.00
528_T 532_K 2.79 1.00
147_M 248_M 2.783 1.00
584_W 589_F 2.708 1.00
152_P 253_P 2.692 1.00
495_N 512_K 2.684 1.00
122_E 223_E 2.568 1.00
131_V 232_V 2.468 0.99
168_V 269_V 2.416 0.99
127_V 159_E 2.371 0.99
464_M 522_L 2.343 0.99
137_L 238_L 2.314 0.99
517_K 525_E 2.259 0.99
167_K 268_K 2.229 0.99
164_V 265_V 2.214 0.98
121_T 222_T 2.179 0.98
115_S 216_G 2.089 0.98
532_K 542_E 2.076 0.97
110_V 211_V 2.076 0.97
118_V 219_V 2.057 0.97
497_G 508_V 2.032 0.97
120_V 221_V 2.017 0.97
474_M 617_I 2.011 0.97
228_V 260_E 2.009 0.97
464_M 496_I 2.006 0.97
163_N 264_N 2.005 0.97
127_V 228_V 1.993 0.96
585_N 588_E 1.986 0.96
159_E 176_V 1.948 0.96
259_K 279_E 1.945 0.96
170_T 271_T 1.899 0.95
125_V 226_V 1.89 0.95
112_D 213_D 1.887 0.95
433_D 592_R 1.881 0.95
169_S 270_K 1.874 0.95
472_E 515_N 1.828 0.94
130_K 231_K 1.813 0.93
163_N 166_D 1.804 0.93
264_N 267_D 1.802 0.93
160_I 261_L 1.794 0.93
177_F 278_F 1.788 0.93
125_V 157_V 1.754 0.92
145_A 246_A 1.753 0.92
231_K 281_E 1.72 0.90
301_A 307_A 1.693 0.90
159_E 260_E 1.692 0.90
585_N 590_V 1.691 0.89
151_A 252_A 1.67 0.89
415_N 418_R 1.652 0.88
154_A 255_A 1.646 0.88
498_V 511_F 1.639 0.87
260_E 277_I 1.639 0.87
162_V 263_V 1.638 0.87
150_P 251_P 1.626 0.87
133_A 154_A 1.625 0.87
7_V 110_V 1.624 0.87
573_L 618_I 1.605 0.86
533_A 538_L 1.6 0.86
166_D 267_D 1.597 0.86
156_T 257_V 1.583 0.85
446_E 449_A 1.579 0.85
114_G 215_G 1.572 0.84
141_E 242_E 1.569 0.84
425_H 600_S 1.565 0.84
410_K 486_Q 1.562 0.84
504_N 536_G 1.537 0.82
531_K 535_D 1.527 0.82
130_K 156_T 1.524 0.82
123_I 224_V 1.522 0.82
329_A 344_L 1.522 0.82
46_V 149_V 1.515 0.81
48_S 51_A 1.514 0.81
239_I 275_I 1.512 0.81
428_H 601_F 1.512 0.81
343_N 346_K 1.504 0.81
175_M 276_M 1.503 0.80
258_V 276_M 1.496 0.80
477_F 570_V 1.493 0.80
463_I 575_V 1.475 0.79
171_G 272_G 1.47 0.78
435_T 592_R 1.469 0.78
123_I 160_I 1.438 0.76
405_L 481_L 1.437 0.76
562_A 597_I 1.434 0.76
526_L 530_S 1.424 0.75
107_D 161_K 1.422 0.75
468_A 494_I 1.414 0.75
132_E 154_A 1.41 0.74
546_G 569_E 1.409 0.74
127_V 160_I 1.409 0.74
403_V 490_L 1.404 0.74
428_H 558_T 1.388 0.73
161_K 173_L 1.379 0.72
480_S 491_K 1.375 0.72
192_Q 309_A 1.36 0.70
172_S 273_S 1.341 0.69
270_K 273_S 1.338 0.69
467_V 618_I 1.332 0.68
30_A 51_A 1.329 0.68
133_A 151_A 1.328 0.68
467_V 573_L 1.327 0.68
571_A 606_I 1.321 0.67
296_A 301_A 1.32 0.67
197_A 306_P 1.317 0.67
226_V 236_Q 1.311 0.66
553_I 556_L 1.306 0.66
337_A 344_L 1.303 0.66
107_D 173_L 1.3 0.65
130_K 180_A 1.296 0.65
158_K 178_E 1.287 0.64
113_I 213_D 1.283 0.64
125_V 135_Q 1.28 0.64
494_I 515_N 1.272 0.63
192_Q 199_A 1.271 0.63
346_K 364_Y 1.268 0.62
64_K 167_K 1.266 0.62
464_M 467_V 1.263 0.62
546_G 549_T 1.259 0.62
140_V 146_S 1.254 0.61
399_E 492_K 1.251 0.61
198_A 286_A 1.25 0.61
187_A 191_K 1.246 0.60
226_V 258_V 1.242 0.60
187_A 192_Q 1.242 0.60
37_V 140_V 1.24 0.60
107_D 176_V 1.239 0.60
108_V 209_V 1.235 0.59
157_V 175_M 1.232 0.59
262_K 277_I 1.232 0.59
173_L 274_L 1.231 0.59
517_K 521_E 1.23 0.59
434_I 595_L 1.227 0.59
428_H 553_I 1.226 0.59
207_K 254_F 1.22 0.58
254_F 278_F 1.215 0.58
546_G 565_V 1.214 0.58
186_A 196_P 1.21 0.57
24_V 70_L 1.208 0.57
464_M 514_V 1.207 0.57
153_F 254_F 1.205 0.57
402_E 487_R 1.204 0.57
231_K 257_V 1.201 0.56
332_L 358_R 1.201 0.56
124_L 136_S 1.196 0.56
143_D 244_D 1.193 0.56
501_D 613_R 1.186 0.55
476_R 610_D 1.184 0.55
508_V 566_N 1.183 0.55
479_S 490_L 1.182 0.54
411_I 415_N 1.182 0.54
513_D 516_K 1.17 0.53
482_S 485_G 1.17 0.53
298_A 301_A 1.163 0.53
423_I 565_V 1.16 0.52
296_A 303_A 1.146 0.51
472_E 494_I 1.143 0.51
109_N 210_N 1.14 0.50
233_A 255_A 1.136 0.50
186_A 197_A 1.135 0.50
429_F 560_H 1.134 0.50
30_A 48_S 1.129 0.49
416_L 508_V 1.125 0.49
625_I 628_L 1.118 0.48
3_I 6_K 1.114 0.48
19_E 122_E 1.113 0.48
432_T 619_N 1.107 0.47
292_Q 305_A 1.107 0.47
563_P 574_G 1.107 0.47
457_I 629_V 1.095 0.46
330_T 336_L 1.092 0.46
438_E 593_L 1.09 0.46
225_M 237_S 1.089 0.46
359_E 362_Q 1.089 0.46
532_K 539_T 1.089 0.46
412_S 416_L 1.087 0.45
131_V 276_M 1.084 0.45
206_V 279_E 1.081 0.45
58_K 70_L 1.081 0.45
188_P 196_P 1.077 0.44
232_V 258_V 1.077 0.44
434_I 578_S 1.074 0.44
24_V 58_K 1.072 0.44
3_I 24_V 1.068 0.44
430_D 458_T 1.067 0.43
208_E 274_L 1.064 0.43
304_E 309_A 1.062 0.43
576_S 601_F 1.061 0.43
24_V 50_Q 1.058 0.43
82_D 87_Q 1.056 0.42
24_V 56_E 1.055 0.42
383_I 386_M 1.052 0.42
546_G 566_N 1.051 0.42
161_K 176_V 1.051 0.42
463_I 620_N 1.05 0.42
473_Q 617_I 1.048 0.42
210_N 274_L 1.043 0.41
158_K 259_K 1.042 0.41
584_W 591_P 1.04 0.41
464_M 526_L 1.039 0.41
194_A 200_P 1.039 0.41
427_T 598_S 1.036 0.41
439_A 442_K 1.036 0.41
3_I 50_Q 1.035 0.40
157_V 226_V 1.033 0.40
189_A 303_A 1.033 0.40
6_K 70_L 1.031 0.40
479_S 605_V 1.031 0.40
408_I 412_S 1.03 0.40
597_I 618_I 1.029 0.40
349_G 356_I 1.025 0.40
496_I 522_L 1.025 0.40
411_I 418_R 1.024 0.39
208_E 277_I 1.023 0.39
328_H 353_K 1.023 0.39
471_L 548_F 1.023 0.39
19_E 71_I 1.021 0.39
59_V 69_A 1.021 0.39
125_V 175_M 1.02 0.39
192_Q 197_A 1.019 0.39
192_Q 305_A 1.018 0.39
508_V 572_I 1.015 0.39
439_A 518_G 1.013 0.38
223_E 564_I 1.013 0.38
55_K 58_K 1.012 0.38
124_L 236_Q 1.012 0.38
340_F 362_Q 1.01 0.38
115_S 330_T 1.007 0.38
553_I 612_A 1.006 0.38
71_I 174_I 1.005 0.38
350_T 495_N 1.002 0.37
3_I 55_K 1.002 0.37
165_G 266_G 1.002 0.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dvaI20.66511000.483Contact Map0.641
1dpbA10.38571000.647Contact Map0.626
2ii3A80.40631000.649Contact Map0.752
1sczA10.36511000.658Contact Map0.67
3maeA30.38731000.659Contact Map0.749
3b8kA10.37621000.663Contact Map0.418
3l60A10.37781000.668Contact Map0.628
3rqcA70.35241000.675Contact Map0.789
2xt6A20.33811000.691Contact Map0.695
1q23A120.33971000.738Contact Map0.49

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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