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OTC2 - Ornithine carbamoyltransferase chain F
UniProt: P06960 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10067
Length: 334 (314)
Sequences: 3591
Seq/Len: 11.44

OTC2
Paralog alert: 0.84 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: OTC1 OTC2 PYRB YGEW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
158_T 183_D 4.264 1.00
258_A 304_E 4.158 1.00
271_F 301_V 3.354 1.00
41_Q 44_T 3.095 1.00
158_T 185_R 3.09 1.00
160_V 226_A 3.049 1.00
220_A 263_L 2.816 1.00
218_D 221_A 2.815 1.00
145_M 228_F 2.797 1.00
99_R 315_D 2.78 1.00
25_T 146_Q 2.641 1.00
270_K 312_I 2.607 1.00
26_L 329_M 2.57 1.00
31_K 147_E 2.535 1.00
227_D 266_N 2.527 1.00
98_G 122_G 2.521 1.00
272_L 312_I 2.453 1.00
148_H 312_I 2.432 1.00
48_I 67_A 2.367 1.00
28_A 146_Q 2.354 1.00
49_A 101_Y 2.354 1.00
91_K 116_T 2.335 1.00
11_K 133_F 2.327 1.00
196_E 200_A 2.288 1.00
67_A 72_A 2.274 1.00
187_L 222_G 2.151 1.00
190_K 217_E 2.148 1.00
258_A 262_A 2.062 1.00
21_T 146_Q 1.992 1.00
183_D 214_T 1.965 1.00
229_I 256_V 1.916 1.00
28_A 143_M 1.914 1.00
259_Q 262_A 1.896 1.00
103_G 328_M 1.887 1.00
177_A 184_L 1.869 1.00
138_L 176_A 1.86 1.00
142_L 176_A 1.846 1.00
183_D 212_K 1.838 1.00
69_D 325_K 1.783 1.00
269_V 310_A 1.77 1.00
223_V 229_I 1.757 1.00
16_T 19_Q 1.748 1.00
216_T 221_A 1.719 1.00
68_F 73_R 1.667 1.00
105_Q 128_G 1.656 1.00
200_A 203_S 1.656 1.00
99_R 318_E 1.653 1.00
220_A 260_M 1.649 1.00
9_F 327_V 1.643 1.00
192_C 250_L 1.64 1.00
53_E 113_V 1.631 1.00
173_M 230_Y 1.615 1.00
17_P 21_T 1.609 1.00
30_L 329_M 1.604 1.00
61_C 97_L 1.601 1.00
148_H 315_D 1.593 1.00
110_G 113_V 1.583 1.00
136_T 324_I 1.583 1.00
17_P 155_N 1.571 1.00
23_L 330_A 1.571 1.00
160_V 187_L 1.533 1.00
204_A 207_E 1.531 1.00
261_M 269_V 1.529 1.00
193_W 217_E 1.523 1.00
185_R 216_T 1.475 1.00
17_P 179_L 1.468 1.00
228_F 270_K 1.46 1.00
57_T 93_T 1.441 1.00
7_K 19_Q 1.416 1.00
264_T 269_V 1.413 1.00
231_T 256_V 1.412 1.00
162_A 223_V 1.405 0.99
230_Y 316_Q 1.403 0.99
188_A 193_W 1.401 0.99
149_L 157_M 1.397 0.99
190_K 193_W 1.394 0.99
136_T 327_V 1.365 0.99
306_F 313_V 1.342 0.99
57_T 87_K 1.337 0.99
308_S 311_S 1.335 0.99
32_A 36_N 1.325 0.99
225_G 266_N 1.324 0.99
24_L 143_M 1.321 0.99
95_R 307_E 1.319 0.99
256_V 271_F 1.314 0.99
149_L 268_N 1.314 0.99
261_M 310_A 1.313 0.99
66_A 328_M 1.31 0.99
224_K 263_L 1.305 0.99
24_L 146_Q 1.302 0.99
261_M 271_F 1.298 0.99
103_G 332_L 1.293 0.99
91_K 120_Y 1.29 0.99
255_Q 302_T 1.289 0.99
296_H 299_M 1.281 0.99
78_G 81_G 1.28 0.99
94_A 117_L 1.27 0.99
199_V 215_L 1.265 0.99
57_T 83_Q 1.254 0.99
160_V 185_R 1.252 0.99
60_R 64_E 1.25 0.99
28_A 147_E 1.25 0.99
9_F 139_L 1.235 0.98
9_F 15_F 1.235 0.98
48_I 105_Q 1.234 0.98
142_L 180_T 1.233 0.98
133_F 175_E 1.214 0.98
221_A 224_K 1.201 0.98
24_L 28_A 1.199 0.98
240_A 243_K 1.191 0.98
205_L 209_H 1.19 0.98
11_K 14_D 1.155 0.97
115_E 119_Q 1.151 0.97
26_L 330_A 1.151 0.97
200_A 204_A 1.15 0.97
26_L 29_Q 1.149 0.97
147_E 319_N 1.147 0.97
104_I 117_L 1.146 0.97
143_M 323_T 1.144 0.97
258_A 308_S 1.143 0.97
11_K 175_E 1.14 0.97
201_E 204_A 1.139 0.97
322_H 325_K 1.136 0.97
104_I 123_V 1.132 0.97
48_I 103_G 1.131 0.97
8_H 118_A 1.131 0.97
157_M 228_F 1.13 0.97
219_V 260_M 1.126 0.97
112_E 116_T 1.123 0.97
31_K 319_N 1.118 0.96
21_T 25_T 1.118 0.96
139_L 327_V 1.113 0.96
13_L 201_E 1.109 0.96
153_A 157_M 1.099 0.96
217_E 254_Y 1.084 0.96
216_T 222_G 1.08 0.95
95_R 314_F 1.079 0.95
318_E 322_H 1.079 0.95
27_A 143_M 1.075 0.95
12_L 176_A 1.074 0.95
257_N 302_T 1.074 0.95
185_R 214_T 1.073 0.95
261_M 301_V 1.064 0.95
21_T 180_T 1.062 0.95
67_A 74_V 1.059 0.95
245_A 249_A 1.059 0.95
83_Q 86_H 1.059 0.95
158_T 225_G 1.054 0.95
256_V 301_V 1.053 0.95
22_S 330_A 1.051 0.94
29_Q 33_D 1.051 0.94
246_E 250_L 1.049 0.94
13_L 175_E 1.046 0.94
108_G 130_T 1.039 0.94
145_M 157_M 1.038 0.94
220_A 259_Q 1.021 0.93
64_E 76_Y 1.021 0.93
69_D 321_M 1.018 0.93
138_L 173_M 1.015 0.93
8_H 121_A 1.015 0.93
48_I 72_A 1.013 0.93
34_K 69_D 1.011 0.93
315_D 318_E 1.01 0.93
138_L 169_M 1.006 0.93
55_D 85_G 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4amuA40.9911000.024Contact Map0.777
1duvG30.9881000.026Contact Map0.796
4h31A30.9881000.029Contact Map0.783
2w37A30.9851000.031Contact Map0.808
1dxhA10.9881000.032Contact Map0.766
1pvvA10.93111000.056Contact Map0.787
1vlvA10.93111000.058Contact Map0.703
4a8tA10.93711000.07Contact Map0.781
4ep1A20.91621000.07Contact Map0.754
4am8A60.92511000.071Contact Map0.826

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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