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FHUA - Ferrichrome-iron receptor
UniProt: P06971 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10302
Length: 747 (685)
Sequences: 13999
Seq/Len: 20.44

FHUA
Paralog alert: 0.92 [within 20: 0.30] - ratio of genomes with paralogs
Cluster includes: BTUB CIRA FECA FEPA FHUA FHUE FIU YDDB YNCD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
621_Y 645_H 5.558 1.00
669_G 689_T 4.616 1.00
575_N 601_R 4.582 1.00
484_G 509_F 4.446 1.00
486_Y 507_K 4.343 1.00
260_T 321_H 4.323 1.00
691_V 717_F 4.134 1.00
529_Y 552_K 3.596 1.00
523_V 558_V 3.571 1.00
531_E 552_K 3.254 1.00
664_T 696_R 3.225 1.00
478_V 517_Y 3.215 1.00
161_R 185_V 3.106 1.00
477_K 517_Y 3.084 1.00
223_Y 254_W 3.072 1.00
159_L 184_M 3.064 1.00
405_H 471_D 3.03 1.00
623_Y 645_H 2.998 1.00
571_G 605_I 2.981 1.00
710_A 742_T 2.927 1.00
268_F 313_K 2.923 1.00
262_F 319_F 2.922 1.00
88_A 92_A 2.9 1.00
260_T 319_F 2.869 1.00
519_F 525_P 2.749 1.00
599_R 629_T 2.728 1.00
671_Y 689_T 2.721 1.00
231_A 246_Y 2.644 1.00
331_Q 392_T 2.616 1.00
270_N 311_N 2.608 1.00
261_N 320_D 2.591 1.00
674_S 684_K 2.587 1.00
615_V 651_A 2.564 1.00
618_V 650_W 2.563 1.00
327_F 396_S 2.563 1.00
480_V 515_V 2.549 1.00
693_A 716_L 2.518 1.00
669_G 691_V 2.51 1.00
711_L 739_V 2.508 1.00
215_D 225_Y 2.507 1.00
266_S 313_K 2.502 1.00
523_V 560_Y 2.474 1.00
486_Y 509_F 2.472 1.00
709_V 743_A 2.459 1.00
567_I 609_A 2.443 1.00
617_V 651_A 2.41 1.00
569_V 607_A 2.41 1.00
199_F 209_T 2.384 1.00
574_Y 624_T 2.377 1.00
410_G 468_Y 2.341 1.00
195_K 213_F 2.318 1.00
478_V 515_V 2.301 1.00
415_R 463_K 2.266 1.00
229_G 246_Y 2.264 1.00
198_Q 744_T 2.231 1.00
667_T 691_V 2.225 1.00
670_R 692_D 2.225 1.00
671_Y 687_S 2.219 1.00
196_E 746_R 2.196 1.00
335_F 388_F 2.193 1.00
668_G 692_D 2.185 1.00
331_Q 390_V 2.182 1.00
712_H 740_V 2.181 1.00
525_P 558_V 2.177 1.00
227_L 250_P 2.163 1.00
721_Y 734_G 2.16 1.00
85_V 163_E 2.159 1.00
614_S 653_Y 2.151 1.00
195_K 747_F 2.138 1.00
333_L 388_F 2.134 1.00
666_G 694_L 2.131 1.00
106_T 164_I 2.129 1.00
556_V 573_V 2.111 1.00
87_T 90_E 2.106 1.00
482_L 513_G 2.088 1.00
571_G 603_V 2.085 1.00
696_R 708_N 2.054 1.00
266_S 315_V 2.039 1.00
108_G 622_T 2.037 1.00
257_D 260_T 2.033 1.00
575_N 599_R 2.032 1.00
411_V 467_V 2.023 1.00
333_L 390_V 2.021 1.00
601_R 625_D 2.016 1.00
163_E 183_N 2 1.00
264_F 317_Y 1.988 1.00
479_L 518_L 1.987 1.00
713_V 716_L 1.98 1.00
581_N 598_I 1.969 1.00
665_L 695_V 1.967 1.00
225_Y 252_F 1.966 1.00
526_Y 572_A 1.957 1.00
327_F 394_L 1.953 1.00
413_F 465_T 1.953 1.00
198_Q 210_G 1.948 1.00
711_L 741_A 1.924 1.00
411_V 465_T 1.911 1.00
160_E 187_K 1.904 1.00
264_F 315_V 1.902 1.00
227_L 248_I 1.895 1.00
259_K 322_E 1.893 1.00
529_Y 554_Y 1.891 1.00
713_V 739_V 1.887 1.00
663_L 697_Y 1.879 1.00
574_Y 622_T 1.879 1.00
698_D 708_N 1.876 1.00
516_N 524_T 1.876 1.00
708_N 744_T 1.875 1.00
223_Y 252_F 1.872 1.00
329_V 392_T 1.871 1.00
89_E 93_L 1.832 1.00
547_A 580_N 1.814 1.00
554_Y 577_T 1.789 1.00
98_S 101_E 1.781 1.00
619_G 649_L 1.769 1.00
259_K 321_H 1.755 1.00
466_G 487_D 1.744 1.00
262_F 317_Y 1.743 1.00
713_V 737_R 1.728 1.00
200_K 742_T 1.724 1.00
692_D 714_N 1.723 1.00
405_H 473_A 1.72 1.00
511_W 531_E 1.719 1.00
263_T 318_S 1.711 1.00
612_S 615_V 1.709 1.00
334_R 389_S 1.708 1.00
702_V 745_F 1.69 1.00
337_E 386_Q 1.686 1.00
531_E 550_K 1.676 1.00
514_G 528_S 1.676 1.00
412_D 466_G 1.676 1.00
393_Q 468_Y 1.67 1.00
191_T 224_S 1.67 1.00
611_L 651_A 1.668 1.00
527_F 556_V 1.665 1.00
229_G 248_I 1.665 1.00
699_L 709_V 1.663 1.00
620_S 648_S 1.659 1.00
520_D 523_V 1.659 1.00
487_D 510_T 1.656 1.00
233_S 244_Q 1.652 1.00
570_T 606_E 1.65 1.00
508_Q 550_K 1.649 1.00
88_A 187_K 1.645 1.00
650_W 668_G 1.644 1.00
126_R 604_E 1.639 1.00
667_T 693_A 1.639 1.00
330_R 393_Q 1.627 1.00
198_Q 742_T 1.627 1.00
477_K 519_F 1.618 1.00
160_E 188_R 1.608 1.00
329_V 394_L 1.608 1.00
550_K 580_N 1.606 1.00
193_P 213_F 1.606 1.00
466_G 485_R 1.595 1.00
139_L 186_S 1.595 1.00
75_P 78_K 1.59 1.00
84_S 166_R 1.584 1.00
475_W 515_V 1.583 1.00
615_V 653_Y 1.581 1.00
573_V 603_V 1.579 1.00
702_V 743_A 1.572 1.00
526_Y 557_G 1.567 1.00
139_L 144_L 1.566 1.00
577_T 599_R 1.565 1.00
225_Y 250_P 1.557 1.00
532_S 551_G 1.548 1.00
224_S 253_T 1.547 1.00
140_N 251_A 1.545 1.00
211_F 229_G 1.541 1.00
196_E 744_T 1.532 1.00
415_R 461_K 1.531 1.00
670_R 690_V 1.529 1.00
91_M 102_A 1.525 1.00
519_F 558_V 1.518 1.00
488_W 507_K 1.517 1.00
140_N 265_L 1.509 1.00
205_S 235_N 1.503 1.00
320_D 328_T 1.494 1.00
690_V 734_G 1.494 1.00
94_H 105_Y 1.489 1.00
691_V 716_L 1.487 1.00
527_F 554_Y 1.48 1.00
190_T 214_S 1.479 1.00
577_T 597_E 1.476 1.00
218_D 222_V 1.473 1.00
616_N 652_D 1.472 1.00
709_V 741_A 1.465 1.00
125_I 180_G 1.455 1.00
406_T 474_Q 1.451 1.00
672_T 688_Y 1.451 1.00
194_L 214_S 1.45 1.00
474_Q 479_L 1.447 1.00
89_E 92_A 1.447 1.00
409_T 469_V 1.444 1.00
101_E 104_S 1.438 1.00
475_W 480_V 1.437 1.00
667_T 716_L 1.429 1.00
253_T 261_N 1.425 1.00
573_V 601_R 1.416 1.00
140_N 186_S 1.415 1.00
109_V 125_I 1.394 0.99
202_G 206_L 1.393 0.99
256_P 262_F 1.39 0.99
598_I 639_P 1.387 0.99
413_F 463_K 1.387 0.99
225_Y 229_G 1.384 0.99
616_N 654_T 1.379 0.99
698_D 746_R 1.373 0.99
400_T 403_I 1.37 0.99
78_K 518_L 1.368 0.99
166_R 604_E 1.367 0.99
222_V 254_W 1.363 0.99
550_K 579_T 1.359 0.99
569_V 605_I 1.357 0.99
647_A 671_Y 1.346 0.99
714_N 738_Q 1.346 0.99
534_E 549_S 1.345 0.99
622_T 646_M 1.343 0.99
397_K 406_T 1.341 0.99
268_F 311_N 1.333 0.99
558_V 571_G 1.332 0.99
123_L 182_L 1.331 0.99
255_R 261_N 1.329 0.99
70_T 74_T 1.328 0.99
230_L 247_A 1.323 0.99
320_D 330_R 1.319 0.99
623_Y 644_K 1.317 0.99
690_V 721_Y 1.31 0.99
645_H 673_G 1.31 0.99
142_L 332_N 1.308 0.99
511_W 515_V 1.305 0.99
603_V 623_Y 1.302 0.99
549_S 578_K 1.298 0.99
663_L 695_V 1.294 0.99
574_Y 602_G 1.293 0.99
693_A 713_V 1.293 0.99
652_D 666_G 1.293 0.99
61_I 93_L 1.292 0.99
621_Y 647_A 1.287 0.99
568_V 608_K 1.287 0.99
256_P 319_F 1.286 0.99
237_Q 736_E 1.286 0.99
231_A 244_Q 1.284 0.99
567_I 607_A 1.279 0.99
708_N 746_R 1.278 0.99
553_Q 576_L 1.278 0.99
624_T 642_V 1.277 0.99
561_V 568_V 1.273 0.99
560_Y 569_V 1.27 0.99
607_A 619_G 1.269 0.99
480_V 513_G 1.266 0.99
406_T 472_Q 1.263 0.99
686_G 719_R 1.261 0.99
716_L 737_R 1.259 0.99
399_A 404_D 1.257 0.99
694_L 710_A 1.255 0.99
566_P 609_A 1.25 0.99
637_N 681_N 1.244 0.98
253_T 263_T 1.243 0.98
515_V 527_F 1.238 0.98
107_P 620_S 1.238 0.98
224_S 255_R 1.232 0.98
201_A 205_S 1.231 0.98
470_Q 481_T 1.231 0.98
526_Y 559_K 1.229 0.98
190_T 194_L 1.229 0.98
323_F 329_V 1.218 0.98
200_K 208_Q 1.215 0.98
515_V 519_F 1.214 0.98
173_Y 181_L 1.21 0.98
328_T 395_Q 1.209 0.98
201_A 207_F 1.208 0.98
163_E 185_V 1.2 0.98
488_W 505_D 1.199 0.98
197_V 745_F 1.196 0.98
188_R 251_A 1.196 0.98
583_M 595_G 1.195 0.98
638_T 644_K 1.192 0.98
518_L 524_T 1.191 0.98
248_I 268_F 1.188 0.98
196_E 212_D 1.183 0.98
324_N 327_F 1.18 0.98
322_E 328_T 1.168 0.97
652_D 664_T 1.165 0.97
472_Q 479_L 1.163 0.97
330_R 395_Q 1.155 0.97
546_F 582_L 1.15 0.97
554_Y 575_N 1.149 0.97
261_N 322_E 1.147 0.97
465_T 488_W 1.145 0.97
394_L 409_T 1.144 0.97
676_Y 684_K 1.142 0.97
600_A 626_A 1.141 0.97
407_L 471_D 1.141 0.97
611_L 617_V 1.135 0.97
391_D 412_D 1.134 0.97
195_K 199_F 1.133 0.97
562_P 569_V 1.125 0.97
525_P 556_V 1.125 0.97
90_E 93_L 1.125 0.97
695_V 713_V 1.123 0.97
718_D 736_E 1.113 0.96
403_I 473_A 1.108 0.96
84_S 606_E 1.107 0.96
619_G 647_A 1.105 0.96
267_Y 314_M 1.1 0.96
743_A 747_F 1.084 0.96
193_P 216_S 1.084 0.96
96_P 102_A 1.083 0.96
213_F 227_L 1.08 0.95
164_I 182_L 1.079 0.95
398_F 407_L 1.079 0.95
193_P 215_D 1.077 0.95
597_E 630_T 1.072 0.95
473_A 482_L 1.07 0.95
710_A 744_T 1.069 0.95
323_F 394_L 1.065 0.95
142_L 334_R 1.064 0.95
126_R 555_E 1.064 0.95
201_A 741_A 1.063 0.95
91_M 96_P 1.058 0.95
141_G 183_N 1.058 0.95
197_V 211_F 1.058 0.95
662_G 697_Y 1.056 0.95
482_L 515_V 1.053 0.95
265_L 316_G 1.053 0.95
125_I 164_I 1.052 0.95
479_L 516_N 1.046 0.94
88_A 160_E 1.039 0.94
126_R 602_G 1.039 0.94
645_H 671_Y 1.036 0.94
90_E 94_H 1.033 0.94
99_V 184_M 1.031 0.94
195_K 211_F 1.03 0.94
400_T 405_H 1.029 0.94
92_A 744_T 1.028 0.94
86_V 106_T 1.028 0.94
699_L 702_V 1.026 0.94
741_A 745_F 1.023 0.93
85_V 161_R 1.02 0.93
519_F 523_V 1.018 0.93
579_T 597_E 1.017 0.93
714_N 740_V 1.014 0.93
617_V 649_L 1.011 0.93
107_P 606_E 1.008 0.93
676_Y 681_N 1.008 0.93
166_R 606_E 1.005 0.93
511_W 529_Y 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1qfgA10.95181000.228Contact Map0.759
3qlbA20.95721000.244Contact Map0.794
3efmA10.90091000.275Contact Map0.806
2w16A20.92771000.296Contact Map0.818
1xkwA10.86611000.298Contact Map0.789
1kmoA10.9051000.333Contact Map0.785
4epaA10.83271000.339Contact Map0.723
3fhhA10.79521000.347Contact Map0.708
2hdiA10.76041000.357Contact Map0.774
4b7oA10.88621000.367Contact Map0.739

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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