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FLIM - Flagellar motor switch protein FliM
UniProt: P06974 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10323
Length: 334 (323)
Sequences: 847
Seq/Len: 2.62

FLIM
Paralog alert: 0.23 [within 20: 0.11] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
263_A 292_I 3.1 1.00
294_A 304_S 2.977 1.00
303_T 319_H 2.574 1.00
8_Q 12_D 2.464 1.00
128_D 135_G 2.278 1.00
304_S 315_L 2.245 1.00
270_L 275_I 2.206 1.00
294_A 315_L 2.11 1.00
166_S 176_E 2.088 1.00
264_N 267_D 1.868 0.99
147_T 150_E 1.816 0.99
123_V 154_I 1.795 0.99
20_E 23_D 1.73 0.98
116_V 217_I 1.689 0.98
266_A 286_I 1.683 0.98
155_N 159_K 1.598 0.96
122_L 206_V 1.587 0.96
260_E 297_D 1.573 0.96
293_I 303_T 1.569 0.96
291_R 318_E 1.567 0.96
293_I 300_P 1.55 0.96
8_Q 15_L 1.55 0.96
65_F 161_A 1.524 0.95
96_L 100_T 1.501 0.94
131_F 153_V 1.498 0.94
95_N 186_V 1.495 0.94
38_Y 128_D 1.495 0.94
95_N 201_N 1.492 0.94
10_E 14_L 1.464 0.93
101_N 151_Q 1.453 0.93
270_L 278_L 1.452 0.93
168_A 231_L 1.435 0.93
257_S 302_L 1.422 0.92
50_R 55_E 1.419 0.92
6_L 10_E 1.418 0.92
124_F 144_R 1.409 0.92
273_S 277_K 1.392 0.91
8_Q 11_I 1.391 0.91
286_I 289_P 1.38 0.90
105_I 162_L 1.376 0.90
68_G 164_G 1.375 0.90
53_A 231_L 1.36 0.90
50_R 228_R 1.348 0.89
284_L 287_E 1.309 0.87
22_K 25_P 1.296 0.86
2_G 9_A 1.288 0.86
170_K 208_I 1.286 0.86
48_R 51_L 1.263 0.84
45_R 103_N 1.263 0.84
48_R 190_N 1.257 0.84
307_G 314_A 1.247 0.83
20_E 25_P 1.243 0.83
179_Y 184_M 1.23 0.82
157_M 217_I 1.227 0.82
264_N 293_I 1.226 0.82
95_N 218_C 1.22 0.81
66_R 146_F 1.219 0.81
275_I 304_S 1.218 0.81
199_V 218_C 1.216 0.81
206_V 215_F 1.213 0.81
77_P 202_T 1.193 0.79
234_P 317_I 1.192 0.79
126_A 157_M 1.188 0.79
70_F 301_V 1.181 0.79
43_Q 99_P 1.174 0.78
58_N 169_W 1.174 0.78
248_D 274_Q 1.174 0.78
263_A 279_N 1.17 0.78
92_F 218_C 1.164 0.77
172_I 215_F 1.163 0.77
62_A 204_F 1.163 0.77
256_H 292_I 1.162 0.77
203_P 214_E 1.16 0.77
63_R 74_R 1.151 0.76
11_I 18_D 1.147 0.76
12_D 97_P 1.146 0.76
149_T 179_Y 1.146 0.76
43_Q 52_Q 1.145 0.75
27_A 32_E 1.144 0.75
7_S 14_L 1.14 0.75
103_N 158_L 1.138 0.75
58_N 202_T 1.136 0.75
305_Q 318_E 1.133 0.74
23_D 26_T 1.13 0.74
278_L 282_D 1.126 0.74
123_V 315_L 1.124 0.74
243_D 246_W 1.117 0.73
91_E 95_N 1.116 0.73
274_Q 284_L 1.108 0.72
21_V 25_P 1.104 0.72
49_E 236_L 1.102 0.71
146_F 153_V 1.095 0.71
75_R 147_T 1.094 0.71
277_K 317_I 1.093 0.71
122_L 213_G 1.093 0.71
221_F 225_E 1.088 0.70
271_R 274_Q 1.086 0.70
268_I 286_I 1.085 0.70
157_M 260_E 1.085 0.70
292_I 304_S 1.085 0.70
262_V 295_H 1.084 0.70
254_V 257_S 1.084 0.70
40_P 298_G 1.083 0.70
21_V 24_E 1.075 0.69
263_A 294_A 1.069 0.68
150_E 319_H 1.066 0.68
22_K 26_T 1.065 0.68
55_E 146_F 1.059 0.67
143_G 179_Y 1.059 0.67
35_I 317_I 1.058 0.67
258_Q 263_A 1.058 0.67
90_H 94_R 1.057 0.67
203_P 259_L 1.055 0.67
291_R 305_Q 1.055 0.67
96_L 158_L 1.053 0.66
300_P 321_I 1.053 0.66
191_I 231_L 1.052 0.66
59_E 63_R 1.051 0.66
99_P 221_F 1.048 0.66
53_A 69_L 1.047 0.66
173_N 217_I 1.045 0.66
169_W 197_D 1.044 0.65
266_A 288_K 1.044 0.65
43_Q 190_N 1.039 0.65
26_T 31_G 1.036 0.65
63_R 135_G 1.036 0.65
267_D 272_L 1.035 0.64
56_I 181_R 1.035 0.64
24_E 32_E 1.034 0.64
56_I 263_A 1.032 0.64
16_N 19_S 1.03 0.64
124_F 150_E 1.03 0.64
24_E 27_A 1.029 0.64
262_V 298_G 1.026 0.63
150_E 223_M 1.026 0.63
249_N 313_Y 1.025 0.63
304_S 308_T 1.024 0.63
34_D 278_L 1.023 0.63
4_S 91_E 1.023 0.63
117_V 301_V 1.022 0.63
220_P 228_R 1.021 0.63
261_L 296_V 1.013 0.62
59_E 217_I 1.011 0.62
110_L 226_P 1.009 0.62
270_L 286_I 1.007 0.61
57_I 218_C 1.005 0.61
282_D 307_G 1.005 0.61
116_V 178_E 1.004 0.61
43_Q 49_E 1.004 0.61
265_F 287_E 1.003 0.61
75_R 209_G 1.002 0.61
21_V 27_A 1.001 0.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4gc8A30.63471000.512Contact Map0.51
4fhrA10.55991000.549Contact Map0.449
4hynA20.57191000.637Contact Map0.453
1xkrA10.55991000.644Contact Map0.225
3qtaA20.649799.90.731Contact Map0.369
1o6aA20.275499.70.777Contact Map0.663
1o9yA40.245599.70.782Contact Map0.609
3uepA20.275499.70.789Contact Map0.68
1squA20.458199.20.841Contact Map0.303
3h2dA20.452198.20.888Contact Map0.479

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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