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HISP - Histidine transport ATP-binding protein HisP
UniProt: P07109 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10452
Length: 257 (241)
Sequences: 70614
Seq/Len: 293.00

HISP
Paralog alert: 0.94 [within 20: 0.87] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
35_S 219_S 3.417 1.00
32_D 221_H 3.13 1.00
7_N 27_Q 3.116 1.00
9_I 61_S 2.948 1.00
10_D 23_G 2.916 1.00
61_S 68_T 2.885 1.00
144_R 148_K 2.839 1.00
93_R 172_E 2.786 1.00
34_I 223_I 2.737 1.00
19_E 22_K 2.679 1.00
7_N 63_V 2.618 1.00
22_K 229_K 2.537 1.00
137_A 142_D 2.532 1.00
29_N 32_D 2.42 1.00
221_H 233_E 2.336 1.00
12_H 23_G 2.303 1.00
8_V 11_L 2.28 1.00
131_R 170_E 2.278 1.00
13_K 50_C 2.218 1.00
234_G 238_Q 2.216 1.00
65_N 172_E 2.186 1.00
14_R 19_E 2.176 1.00
143_E 146_Q 2.145 1.00
12_H 19_E 2.057 1.00
109_V 153_L 2.056 1.00
133_V 146_Q 2.021 1.00
235_A 238_Q 2.019 1.00
136_L 146_Q 1.993 1.00
110_L 147_G 1.991 1.00
223_I 230_I 1.982 1.00
12_H 59_E 1.976 1.00
30_A 172_E 1.878 1.00
110_L 146_Q 1.838 1.00
9_I 63_V 1.804 1.00
10_D 25_S 1.796 1.00
110_L 133_V 1.775 1.00
32_D 220_T 1.76 1.00
15_Y 20_V 1.756 1.00
110_L 132_A 1.718 1.00
170_E 203_K 1.705 1.00
223_I 233_E 1.682 1.00
138_K 197_Q 1.656 1.00
13_K 58_S 1.654 1.00
131_R 134_K 1.629 1.00
124_S 127_E 1.608 1.00
138_K 201_E 1.566 1.00
129_R 133_V 1.554 1.00
134_K 138_K 1.528 1.00
148_K 152_H 1.485 1.00
99_Q 155_G 1.476 1.00
197_Q 201_E 1.464 1.00
234_G 239_L 1.454 1.00
63_V 68_T 1.431 1.00
21_L 50_C 1.43 1.00
9_I 27_Q 1.429 1.00
14_R 58_S 1.422 1.00
110_L 129_R 1.415 1.00
13_K 55_E 1.414 1.00
199_A 220_T 1.399 0.99
209_T 215_A 1.399 0.99
114_M 132_A 1.379 0.99
48_L 208_V 1.367 0.99
28_A 34_I 1.36 0.99
8_V 51_I 1.357 0.99
130_E 134_K 1.355 0.99
114_M 128_A 1.353 0.99
65_N 93_R 1.343 0.99
26_L 223_I 1.335 0.99
50_C 57_P 1.326 0.99
113_V 168_A 1.307 0.99
34_I 233_E 1.293 0.99
12_H 22_K 1.276 0.99
142_D 146_Q 1.275 0.99
8_V 26_L 1.263 0.99
110_L 114_M 1.256 0.99
5_K 65_N 1.243 0.98
15_Y 46_T 1.227 0.98
131_R 135_Y 1.224 0.98
9_I 25_S 1.219 0.98
135_Y 168_A 1.218 0.98
108_T 111_E 1.212 0.98
176_F 195_M 1.212 0.98
68_T 71_L 1.206 0.98
109_V 161_V 1.191 0.98
112_N 165_R 1.189 0.98
33_V 199_A 1.183 0.98
11_L 57_P 1.167 0.97
83_D 86_Q 1.153 0.97
33_V 205_M 1.153 0.97
196_Q 199_A 1.15 0.97
133_V 137_A 1.142 0.97
50_C 62_I 1.129 0.97
51_I 206_V 1.129 0.97
245_S 248_L 1.125 0.97
47_F 225_L 1.119 0.96
48_L 175_L 1.118 0.96
29_N 221_H 1.106 0.96
231_E 245_S 1.103 0.96
176_F 205_M 1.102 0.96
153_L 161_V 1.101 0.96
139_V 164_A 1.087 0.96
8_V 47_F 1.086 0.96
97_V 163_I 1.084 0.96
24_V 47_F 1.076 0.95
49_R 55_E 1.075 0.95
144_R 157_Q 1.073 0.95
127_E 130_E 1.069 0.95
172_E 203_K 1.068 0.95
114_M 129_R 1.067 0.95
67_Q 86_Q 1.067 0.95
133_V 142_D 1.061 0.95
30_A 65_N 1.056 0.95
174_L 205_M 1.042 0.94
188_V 214_F 1.038 0.94
34_I 221_H 1.036 0.94
194_I 197_Q 1.033 0.94
134_K 137_A 1.032 0.94
13_K 46_T 1.029 0.94
192_L 214_F 1.027 0.94
10_D 59_E 1.023 0.93
199_A 205_M 1.019 0.93
149_Y 152_H 1.014 0.93
52_N 96_M 1.012 0.93
52_N 175_L 1.009 0.93
108_T 147_G 1.005 0.93
111_E 114_M 1.002 0.92
126_Q 130_E 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.9533100-0.032Contact Map0.878
1v43A10.9339100-0.023Contact Map0.825
2it1A20.9261100-0.022Contact Map0.87
2yyzA10.9261100-0.021Contact Map0.813
1oxxK10.9455100-0.018Contact Map0.806
1g29120.9455100-0.017Contact Map0.896
3rlfA20.9261100-0.012Contact Map0.838
3fvqA20.9455100-0.012Contact Map0.779
1z47A20.9339100-0.005Contact Map0.831
1b0uA10.9961100-0.003Contact Map0.789

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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