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CHEA - Chemotaxis protein CheA
UniProt: P07363 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10146
Length: 654 (645)
Sequences: 1630
Seq/Len: 2.53

CHEA
Paralog alert: 0.28 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
425_L 430_I 6.854 1.00
350_Q 399_S 5.473 1.00
391_K 423_A 5.461 1.00
393_L 399_S 4.803 1.00
494_K 497_T 4.426 1.00
395_A 496_G 4.214 1.00
352_E 400_V 3.806 1.00
33_E 36_D 3.451 1.00
388_L 391_K 3.208 1.00
514_G 525_I 3.164 1.00
518_R 598_Q 3.146 1.00
426_N 495_Q 3.048 1.00
419_T 500_T 2.893 1.00
356_V 404_I 2.862 1.00
354_T 402_N 2.792 1.00
454_I 475_M 2.716 1.00
446_S 449_E 2.711 1.00
533_E 555_R 2.704 1.00
455_F 489_V 2.677 1.00
433_K 436_S 2.671 1.00
425_L 451_A 2.652 1.00
561_I 582_V 2.526 1.00
427_R 431_L 2.492 1.00
427_R 447_D 2.481 1.00
447_D 450_V 2.476 1.00
391_K 395_A 2.441 1.00
431_L 450_V 2.407 1.00
427_R 450_V 2.373 1.00
350_Q 400_V 2.354 1.00
451_A 493_S 2.252 1.00
429_R 463_E 2.252 1.00
93_E 122_A 2.228 1.00
568_F 635_V 2.162 1.00
383_D 469_S 2.158 1.00
343_L 468_V 2.157 1.00
514_G 605_V 2.157 1.00
557_E 591_R 2.072 1.00
382_L 403_L 2.062 1.00
428_E 432_A 2.04 1.00
455_F 491_I 1.936 0.99
44_F 77_R 1.922 0.99
432_A 436_S 1.886 0.99
75_E 80_E 1.861 0.99
462_A 465_V 1.853 0.99
351_V 382_L 1.849 0.99
427_R 451_A 1.843 0.99
346_K 467_D 1.83 0.99
204_A 207_D 1.813 0.99
356_V 406_S 1.798 0.98
518_R 521_D 1.796 0.98
386_I 401_G 1.788 0.98
19_L 46_A 1.766 0.98
436_S 463_E 1.754 0.98
559_L 584_I 1.746 0.98
339_L 343_L 1.746 0.98
205_E 209_T 1.744 0.98
391_K 394_A 1.732 0.98
40_L 76_A 1.715 0.98
582_V 593_A 1.713 0.98
439_L 456_A 1.71 0.98
404_I 419_T 1.699 0.98
425_L 454_I 1.687 0.97
89_N 345_G 1.686 0.97
352_E 402_N 1.685 0.97
88_I 92_L 1.677 0.97
17_D 106_K 1.621 0.97
335_R 371_I 1.619 0.97
12_F 54_A 1.614 0.96
408_E 417_E 1.609 0.96
549_E 563_E 1.598 0.96
430_I 450_V 1.595 0.96
31_Q 341_R 1.586 0.96
406_S 417_E 1.57 0.96
538_R 541_D 1.566 0.96
427_R 495_Q 1.561 0.95
169_A 172_V 1.533 0.95
69_M 94_T 1.522 0.95
413_N 504_L 1.517 0.94
427_R 493_S 1.505 0.94
330_E 358_S 1.493 0.94
492_Q 502_R 1.47 0.93
431_L 435_A 1.467 0.93
24_E 99_Q 1.467 0.93
516_S 626_L 1.465 0.93
69_M 91_F 1.463 0.93
55_G 63_Q 1.463 0.93
68_L 124_R 1.452 0.93
524_F 570_V 1.452 0.93
417_E 502_R 1.45 0.93
451_A 491_I 1.441 0.92
179_L 183_T 1.427 0.92
366_L 370_I 1.427 0.92
450_V 453_L 1.42 0.92
76_A 83_L 1.417 0.91
553_E 556_G 1.414 0.91
37_A 41_N 1.409 0.91
410_Q 504_L 1.407 0.91
486_G 607_V 1.404 0.91
19_L 49_S 1.402 0.91
513_D 602_Q 1.399 0.91
28_L 342_D 1.395 0.91
475_M 501_I 1.394 0.91
47_A 66_T 1.394 0.91
24_E 92_L 1.391 0.90
28_L 31_Q 1.38 0.90
489_V 501_I 1.356 0.89
532_M 586_Q 1.35 0.89
264_I 364_K 1.348 0.88
370_I 481_N 1.346 0.88
26_H 42_A 1.345 0.88
329_M 333_F 1.333 0.88
48_H 51_K 1.326 0.87
409_H 509_L 1.322 0.87
528_L 636_D 1.322 0.87
96_D 342_D 1.32 0.87
206_D 209_T 1.312 0.87
333_F 405_L 1.311 0.87
429_R 432_A 1.309 0.86
16_A 50_I 1.301 0.86
31_Q 342_D 1.296 0.86
423_A 429_R 1.293 0.86
403_L 499_T 1.289 0.85
347_L 468_V 1.284 0.85
372_D 481_N 1.279 0.85
49_S 53_G 1.278 0.85
513_D 604_Q 1.27 0.84
350_Q 389_P 1.26 0.83
466_T 631_V 1.257 0.83
509_L 606_V 1.257 0.83
69_M 98_M 1.244 0.82
188_V 192_A 1.241 0.82
283_I 286_S 1.24 0.82
606_V 634_I 1.237 0.82
74_D 78_R 1.235 0.82
435_A 442_S 1.232 0.82
433_K 437_Q 1.232 0.82
103_D 107_Q 1.232 0.82
389_P 393_L 1.222 0.81
473_V 476_D 1.221 0.81
73_L 417_E 1.217 0.80
447_D 489_V 1.216 0.80
388_L 423_A 1.205 0.80
605_V 628_D 1.203 0.79
526_L 583_V 1.201 0.79
22_D 46_A 1.201 0.79
96_D 338_R 1.2 0.79
432_A 435_A 1.199 0.79
439_L 453_L 1.198 0.79
49_S 346_K 1.197 0.79
54_A 63_Q 1.189 0.78
45_R 48_H 1.185 0.78
279_G 475_M 1.184 0.78
532_M 591_R 1.184 0.78
75_E 81_M 1.183 0.78
479_K 483_Q 1.183 0.78
482_I 503_I 1.181 0.78
525_I 624_T 1.18 0.78
339_L 375_T 1.179 0.77
395_A 423_A 1.178 0.77
514_G 604_Q 1.176 0.77
264_I 271_V 1.172 0.77
24_E 28_L 1.169 0.77
550_R 563_E 1.168 0.77
425_L 491_I 1.159 0.76
433_K 477_V 1.154 0.75
92_L 338_R 1.154 0.75
203_I 207_D 1.149 0.75
473_V 477_V 1.146 0.75
386_I 423_A 1.142 0.74
350_Q 393_L 1.14 0.74
68_L 71_N 1.136 0.74
283_I 312_R 1.132 0.73
447_D 494_K 1.128 0.73
48_H 70_E 1.125 0.73
491_I 501_I 1.121 0.72
368_E 481_N 1.121 0.72
554_V 584_I 1.121 0.72
318_Q 605_V 1.119 0.72
423_A 426_N 1.116 0.72
336_Y 377_L 1.114 0.72
30_L 34_A 1.112 0.71
525_I 605_V 1.111 0.71
168_K 172_V 1.108 0.71
45_R 51_K 1.106 0.71
494_K 500_T 1.105 0.71
417_E 500_T 1.102 0.70
434_A 453_L 1.1 0.70
84_N 87_I 1.099 0.70
102_L 352_E 1.099 0.70
192_A 195_L 1.096 0.70
47_A 56_T 1.093 0.70
47_A 69_M 1.091 0.69
8_F 53_G 1.091 0.69
347_L 382_L 1.091 0.69
360_T 411_G 1.088 0.69
309_Q 370_I 1.086 0.69
19_L 22_D 1.085 0.69
525_I 632_A 1.083 0.68
218_A 223_F 1.081 0.68
243_E 246_P 1.08 0.68
141_L 248_G 1.08 0.68
37_A 79_G 1.078 0.68
171_E 175_L 1.077 0.68
364_K 378_V 1.073 0.67
45_R 70_E 1.073 0.67
216_I 219_D 1.072 0.67
53_G 57_F 1.071 0.67
188_V 191_G 1.063 0.66
276_N 608_K 1.062 0.66
51_K 70_E 1.062 0.66
278_V 510_A 1.058 0.66
12_F 15_E 1.058 0.66
51_K 67_H 1.053 0.65
15_E 326_M 1.053 0.65
285_Q 323_S 1.053 0.65
362_L 511_I 1.052 0.65
510_A 591_R 1.052 0.65
28_L 92_L 1.05 0.65
528_L 602_Q 1.049 0.65
516_S 525_I 1.047 0.65
326_M 601_G 1.046 0.65
50_I 475_M 1.044 0.64
333_F 407_A 1.044 0.64
351_V 386_I 1.042 0.64
321_V 324_I 1.036 0.63
372_D 477_V 1.035 0.63
175_L 183_T 1.034 0.63
188_V 193_D 1.034 0.63
77_R 372_D 1.033 0.63
318_Q 322_M 1.033 0.63
431_L 445_M 1.031 0.63
49_S 315_R 1.03 0.63
488_H 504_L 1.029 0.63
406_S 419_T 1.024 0.62
13_F 105_Y 1.021 0.62
520_A 570_V 1.021 0.62
362_L 366_L 1.02 0.62
454_I 631_V 1.02 0.62
592_Y 641_Q 1.016 0.61
76_A 87_I 1.015 0.61
625_I 631_V 1.015 0.61
67_H 70_E 1.013 0.61
479_K 566_K 1.013 0.61
53_G 56_T 1.008 0.60
427_R 430_I 1.008 0.60
607_V 634_I 1.007 0.60
71_N 74_D 1.006 0.60
285_Q 604_Q 1.005 0.60
383_D 466_T 1.003 0.60
340_V 382_L 1.002 0.60
57_F 312_R 1.001 0.60
75_E 78_R 1.001 0.60
525_I 604_Q 1.001 0.60
378_V 403_L 1 0.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1b3qA20.57491000.504Contact Map0.714
2lp4A10.3441000.814Contact Map0.638
1i58A20.28441000.83Contact Map0.775
1i5nA40.22321000.848Contact Map0.721
3kyjA10.212599.90.86Contact Map0.711
2lchA10.172899.90.868Contact Map0.66
2ld6A10.21199.90.87Contact Map0.744
4jpbW10.220299.90.881Contact Map0.681
2qdlA20.229499.80.884Contact Map0.707
1tqgA10.160699.80.884Contact Map0.749

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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