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CHER - Chemotaxis protein methyltransferase
UniProt: P07364 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10148
Length: 286 (265)
Sequences: 2123
Seq/Len: 8.01

CHER
Paralog alert: 0.36 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
126_T 159_V 3.19 1.00
177_T 180_Q 3.043 1.00
57_R 81_E 2.984 1.00
227_I 248_F 2.858 1.00
120_W 153_S 2.772 1.00
274_T 282_A 2.764 1.00
69_Y 81_E 2.687 1.00
130_P 152_A 2.6 1.00
225_D 253_K 2.53 1.00
65_D 68_H 2.501 1.00
57_R 69_Y 2.434 1.00
153_S 211_L 2.411 1.00
252_L 256_G 2.388 1.00
138_A 202_L 2.195 1.00
128_E 172_E 2.167 1.00
102_H 259_F 2.15 1.00
26_H 67_G 2.144 1.00
106_L 226_A 2.13 1.00
119_V 133_I 2.113 1.00
249_V 273_F 2.107 1.00
133_I 228_F 2.089 1.00
227_I 252_L 2.07 1.00
92_N 159_V 2.021 1.00
132_S 136_T 1.986 1.00
213_L 232_V 1.981 1.00
167_I 197_R 1.977 1.00
152_A 206_V 1.937 1.00
92_N 125_S 1.894 1.00
58_L 63_L 1.884 1.00
64_T 68_H 1.863 1.00
72_L 76_N 1.854 1.00
202_L 205_Y 1.852 1.00
180_Q 184_Y 1.818 1.00
104_P 108_D 1.792 1.00
188_G 197_R 1.789 1.00
186_M 199_R 1.784 1.00
214_L 240_T 1.763 1.00
160_L 210_P 1.742 1.00
139_D 180_Q 1.719 1.00
122_A 213_L 1.714 1.00
173_L 181_L 1.698 1.00
130_P 206_V 1.696 1.00
138_A 205_Y 1.668 1.00
198_V 202_L 1.637 1.00
149_K 207_D 1.635 1.00
200_Q 204_N 1.635 1.00
233_M 260_A 1.607 1.00
157_T 210_P 1.589 1.00
63_L 72_L 1.586 1.00
200_Q 203_A 1.568 1.00
139_D 183_R 1.567 1.00
32_Q 36_Q 1.567 1.00
167_I 195_L 1.552 1.00
178_P 182_Q 1.535 1.00
138_A 201_E 1.522 1.00
148_W 205_Y 1.488 0.99
87_N 156_D 1.468 0.99
169_R 172_E 1.464 0.99
121_S 228_F 1.464 0.99
106_L 133_I 1.438 0.99
161_E 164_R 1.413 0.99
135_M 139_D 1.392 0.99
104_P 107_A 1.39 0.99
233_M 244_I 1.386 0.99
137_L 148_W 1.384 0.99
94_T 126_T 1.382 0.99
46_K 53_R 1.373 0.99
97_F 132_S 1.369 0.99
135_M 184_Y 1.366 0.99
118_R 149_K 1.359 0.99
134_A 205_Y 1.349 0.99
166_G 198_V 1.338 0.99
257_L 276_R 1.331 0.99
122_A 232_V 1.328 0.99
57_R 60_S 1.327 0.99
243_E 247_R 1.326 0.99
130_P 150_V 1.295 0.98
178_P 181_L 1.287 0.98
229_C 248_F 1.285 0.98
107_A 139_D 1.284 0.98
233_M 245_L 1.277 0.98
202_L 206_V 1.271 0.98
99_E 102_H 1.268 0.98
125_S 159_V 1.262 0.98
90_T 155_I 1.252 0.98
238_Q 241_Q 1.251 0.98
119_V 137_L 1.25 0.98
151_F 209_A 1.25 0.98
92_N 156_D 1.248 0.98
249_V 272_R 1.248 0.98
237_D 240_T 1.23 0.97
135_M 185_F 1.215 0.97
123_A 232_V 1.214 0.97
157_T 161_E 1.212 0.97
162_K 165_S 1.194 0.97
170_H 196_V 1.192 0.97
50_V 89_L 1.188 0.96
97_F 180_Q 1.187 0.96
134_A 150_V 1.183 0.96
161_E 165_S 1.182 0.96
242_Q 246_R 1.171 0.96
123_A 248_F 1.165 0.96
68_H 71_N 1.165 0.96
103_F 132_S 1.161 0.96
52_N 91_T 1.158 0.96
100_A 104_P 1.155 0.96
87_N 158_E 1.155 0.96
24_D 47_R 1.154 0.96
35_Y 237_D 1.146 0.95
124_A 130_P 1.146 0.95
49_M 91_T 1.142 0.95
61_L 72_L 1.142 0.95
69_Y 85_F 1.118 0.95
232_V 236_F 1.117 0.95
152_A 229_C 1.111 0.94
150_V 205_Y 1.097 0.94
246_R 272_R 1.094 0.94
121_S 133_I 1.092 0.94
228_F 259_F 1.082 0.93
57_R 85_F 1.081 0.93
116_E 147_R 1.076 0.93
121_S 124_A 1.07 0.93
37_R 82_W 1.061 0.92
218_Y 244_I 1.059 0.92
57_R 61_L 1.056 0.92
90_T 156_D 1.052 0.92
248_F 273_F 1.05 0.92
151_F 224_F 1.042 0.91
95_A 175_N 1.03 0.91
73_L 85_F 1.027 0.91
57_R 88_S 1.026 0.91
102_H 262_H 1.015 0.90
83_Q 157_T 1.014 0.90
123_A 244_I 1.013 0.90
171_E 174_K 1.011 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1af7A10.9581000.306Contact Map0.792
4gqbA10.83571000.69Contact Map0.463
3i53A20.842799.80.778Contact Map0.512
3gwzA40.842799.70.8Contact Map0.553
2ip2A20.842799.60.809Contact Map0.493
1tw3A20.839299.60.811Contact Map0.537
1qzzA10.842799.60.817Contact Map0.53
1o9gA10.737899.50.821Contact Map0.435
2r3sA20.842799.50.822Contact Map0.605
3lstA20.825299.50.824Contact Map0.475

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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