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AROB - 3-dehydroquinate synthase
UniProt: P07639 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10074
Length: 362 (354)
Sequences: 6443
Seq/Len: 18.20

AROB
Paralog alert: 0.75 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: ADH2 AROB EUTG FUCO GLDA YBDH YQHD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
86_T 90_Q 3.688 1.00
217_Y 224_E 3.04 1.00
221_R 224_E 2.912 1.00
99_L 111_T 2.884 1.00
51_D 55_G 2.873 1.00
311_S 314_A 2.83 1.00
20_G 168_D 2.676 1.00
216_A 299_R 2.646 1.00
79_A 148_P 2.551 1.00
84_V 114_A 2.536 1.00
176_R 266_E 2.527 1.00
19_S 168_D 2.502 1.00
36_Q 63_N 2.502 1.00
51_D 54_R 2.309 1.00
108_G 126_Q 2.275 1.00
37_V 98_T 2.22 1.00
54_R 58_E 2.191 1.00
180_S 266_E 2.175 1.00
175_P 179_A 2.169 1.00
44_T 48_L 2.144 1.00
295_T 299_R 2.054 1.00
23_N 52_K 2.023 1.00
250_G 267_A 1.959 1.00
87_A 91_K 1.954 1.00
201_E 292_R 1.949 1.00
81_L 110_L 1.93 1.00
165_V 230_V 1.927 1.00
73_E 80_V 1.923 1.00
291_Q 295_T 1.912 1.00
85_F 117_S 1.9 1.00
88_L 93_H 1.872 1.00
83_T 86_T 1.855 1.00
185_V 211_D 1.853 1.00
123_R 161_A 1.836 1.00
298_K 304_V 1.817 1.00
71_D 83_T 1.813 1.00
214_A 228_E 1.809 1.00
336_L 340_K 1.783 1.00
287_S 291_Q 1.782 1.00
171_K 225_L 1.781 1.00
305_N 308_R 1.774 1.00
101_A 111_T 1.737 1.00
58_E 64_V 1.733 1.00
314_A 317_P 1.722 1.00
25_P 56_V 1.721 1.00
88_L 122_V 1.717 1.00
217_Y 221_R 1.673 1.00
40_V 114_A 1.665 1.00
21_L 24_E 1.623 1.00
277_R 294_I 1.619 1.00
52_K 168_D 1.617 1.00
116_A 156_A 1.607 1.00
42_N 45_L 1.603 1.00
245_L 272_M 1.602 1.00
87_A 90_Q 1.595 1.00
108_G 137_S 1.581 1.00
282_L 351_L 1.562 1.00
80_V 83_T 1.533 1.00
37_V 100_V 1.523 1.00
348_S 351_L 1.506 1.00
28_F 98_T 1.505 1.00
43_E 47_P 1.502 1.00
276_A 293_I 1.493 1.00
55_G 59_Q 1.487 1.00
174_P 177_E 1.486 1.00
170_L 230_V 1.485 1.00
40_V 111_T 1.466 1.00
262_W 267_A 1.461 1.00
19_S 171_K 1.461 1.00
286_S 289_E 1.455 1.00
73_E 77_S 1.451 1.00
81_L 114_A 1.449 1.00
125_I 162_S 1.442 1.00
81_L 145_V 1.429 1.00
224_E 228_E 1.425 1.00
98_T 125_I 1.422 1.00
27_S 30_P 1.42 1.00
232_A 239_L 1.419 1.00
35_E 97_T 1.409 1.00
40_V 72_G 1.407 0.99
46_A 50_L 1.405 0.99
43_E 70_P 1.397 0.99
115_A 121_G 1.38 0.99
67_V 87_A 1.374 0.99
313_Q 353_L 1.374 0.99
183_A 297_L 1.364 0.99
53_V 102_L 1.355 0.99
216_A 220_R 1.354 0.99
20_G 166_D 1.351 0.99
214_A 217_Y 1.348 0.99
249_F 271_G 1.341 0.99
294_I 298_K 1.34 0.99
212_G 282_L 1.34 0.99
168_D 171_K 1.333 0.99
113_F 117_S 1.333 0.99
78_L 82_D 1.313 0.99
38_M 87_A 1.298 0.99
46_A 70_P 1.295 0.99
183_A 302_L 1.289 0.99
39_L 64_V 1.286 0.99
281_R 354_N 1.284 0.99
292_R 295_T 1.281 0.99
190_I 335_P 1.279 0.99
38_M 88_L 1.271 0.99
182_L 215_M 1.269 0.99
178_L 218_C 1.258 0.99
239_L 242_L 1.256 0.99
217_Y 226_K 1.252 0.99
173_L 177_E 1.244 0.98
38_M 67_V 1.234 0.98
101_A 108_G 1.227 0.98
82_D 86_T 1.222 0.98
256_E 318_H 1.221 0.98
93_H 97_T 1.219 0.98
38_M 93_H 1.209 0.98
336_L 342_E 1.208 0.98
335_P 341_S 1.207 0.98
142_K 154_I 1.202 0.98
279_S 335_P 1.202 0.98
182_L 229_V 1.196 0.98
58_E 63_N 1.193 0.98
45_L 48_L 1.192 0.98
99_L 115_A 1.191 0.98
224_E 227_A 1.19 0.98
5_V 14_P 1.175 0.98
131_L 178_L 1.171 0.98
54_R 64_V 1.168 0.97
220_R 224_E 1.158 0.97
101_A 126_Q 1.143 0.97
193_D 221_R 1.134 0.97
188_Y 222_C 1.129 0.97
250_G 268_V 1.129 0.97
55_G 58_E 1.127 0.97
88_L 99_L 1.118 0.96
16_T 24_E 1.116 0.96
187_K 272_M 1.114 0.96
43_E 71_D 1.111 0.96
279_S 289_E 1.11 0.96
329_E 346_G 1.109 0.96
69_L 75_Y 1.105 0.96
65_D 91_K 1.104 0.96
180_S 263_L 1.103 0.96
24_E 27_S 1.102 0.96
29_L 60_A 1.102 0.96
39_L 54_R 1.092 0.96
235_R 239_L 1.09 0.96
108_G 128_P 1.09 0.96
78_L 145_V 1.089 0.96
228_E 232_A 1.083 0.96
44_T 47_P 1.08 0.95
218_C 222_C 1.077 0.95
189_G 237_T 1.076 0.95
273_V 294_I 1.076 0.95
36_Q 92_P 1.074 0.95
34_G 98_T 1.072 0.95
213_P 217_Y 1.071 0.95
337_A 340_K 1.067 0.95
18_A 24_E 1.055 0.95
277_R 280_E 1.054 0.95
58_E 61_G 1.054 0.95
99_L 122_V 1.051 0.94
197_F 276_A 1.048 0.94
79_A 82_D 1.045 0.94
27_S 162_S 1.043 0.94
288_A 291_Q 1.04 0.94
291_Q 294_I 1.036 0.94
270_A 273_V 1.032 0.94
15_I 235_R 1.031 0.94
212_G 216_A 1.013 0.93
250_G 254_E 1.011 0.93
195_A 198_N 1.008 0.93
333_I 343_V 1.008 0.93
52_K 55_G 1.008 0.93
86_T 89_L 1.007 0.93
178_L 222_C 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3okfA20.99451000.107Contact Map0.622
2gruA20.98621000.118Contact Map0.59
3zokA411000.12Contact Map0.714
3qbeA10.98071000.138Contact Map0.642
1xahA20.96411000.144Contact Map0.675
1sg6A20.97511000.152Contact Map0.659
1ujnA20.93651000.159Contact Map0.583
3clhA20.94751000.174Contact Map0.659
3ox4A40.91161000.216Contact Map0.791
1rrmA20.91441000.225Contact Map0.74

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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