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FHUC - Iron(3+)-hydroxamate import ATP-binding protein FhuC
UniProt: P07821 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10304
Length: 265 (238)
Sequences: 71252
Seq/Len: 299.38

FHUC
Paralog alert: 0.94 [within 20: 0.85] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
41_G 215_C 3.264 1.00
38_K 217_Y 3.156 1.00
13_A 33_T 3.149 1.00
15_R 67_E 2.96 1.00
67_E 74_P 2.947 1.00
16_N 29_P 2.927 1.00
140_L 143_R 2.916 1.00
133_S 138_K 2.843 1.00
25_T 28_H 2.683 1.00
40_T 219_V 2.666 1.00
35_P 38_K 2.618 1.00
13_A 69_L 2.611 1.00
28_H 225_E 2.606 1.00
86_K 167_R 2.562 1.00
217_Y 229_Q 2.548 1.00
18_S 29_P 2.332 1.00
14_L 17_I 2.303 1.00
20_R 25_T 2.174 1.00
18_S 25_T 2.17 1.00
230_G 234_E 2.127 1.00
127_K 165_D 2.119 1.00
18_S 65_E 2.08 1.00
102_V 148_L 2.074 1.00
19_F 56_M 2.056 1.00
15_R 69_L 2.032 1.00
231_T 234_E 2.013 1.00
132_I 141_A 1.983 1.00
71_D 167_R 1.981 1.00
129_E 141_A 1.874 1.00
165_D 199_L 1.856 1.00
134_L 192_R 1.803 1.00
36_A 167_R 1.786 1.00
21_V 26_L 1.766 1.00
103_R 129_E 1.761 1.00
38_K 216_D 1.76 1.00
16_N 31_S 1.738 1.00
103_R 141_A 1.73 1.00
103_R 142_H 1.712 1.00
219_V 226_M 1.707 1.00
219_V 229_Q 1.679 1.00
192_R 196_E 1.674 1.00
130_E 134_L 1.629 1.00
19_F 64_S 1.589 1.00
103_R 128_V 1.56 1.00
54_L 204_V 1.55 1.00
54_L 170_L 1.55 1.00
20_R 64_S 1.548 1.00
103_R 107_A 1.545 1.00
125_R 129_E 1.538 1.00
92_Q 150_G 1.495 1.00
103_R 125_R 1.484 1.00
127_K 130_E 1.459 1.00
32_L 219_V 1.453 1.00
27_L 56_M 1.437 1.00
34_F 40_T 1.417 1.00
100_M 104_E 1.413 1.00
143_R 147_S 1.397 0.99
129_E 133_S 1.359 0.99
14_L 57_L 1.35 0.99
19_F 61_Q 1.35 0.99
15_R 33_T 1.346 0.99
138_K 141_A 1.343 0.99
69_L 74_P 1.324 0.99
56_M 63_P 1.318 0.99
134_L 197_R 1.318 0.99
11_T 71_D 1.313 0.99
129_E 138_K 1.31 0.99
14_L 32_L 1.305 0.99
18_S 28_H 1.282 0.99
106_V 163_A 1.274 0.99
126_E 130_E 1.272 0.99
105_L 160_M 1.272 0.99
140_L 152_E 1.264 0.99
171_L 190_V 1.261 0.99
205_L 211_A 1.259 0.99
107_A 128_V 1.253 0.99
230_G 235_I 1.247 0.99
17_I 63_P 1.24 0.98
194_S 216_D 1.222 0.98
79_S 82_A 1.219 0.98
101_T 104_E 1.217 0.98
120_F 123_A 1.193 0.98
19_F 52_T 1.183 0.98
53_L 221_L 1.18 0.98
35_P 217_Y 1.173 0.98
40_T 229_Q 1.167 0.97
71_D 86_K 1.159 0.97
15_R 31_S 1.154 0.97
127_K 131_A 1.152 0.97
88_A 166_S 1.151 0.97
106_V 132_I 1.143 0.97
107_A 125_R 1.134 0.97
137_L 140_L 1.13 0.97
102_V 156_A 1.112 0.96
132_I 137_L 1.107 0.96
14_L 53_L 1.105 0.96
167_R 199_L 1.094 0.96
135_V 159_A 1.084 0.96
58_G 89_Y 1.081 0.95
40_T 217_Y 1.073 0.95
130_E 133_S 1.072 0.95
59_R 62_P 1.068 0.95
107_A 124_D 1.064 0.95
73_Q 86_K 1.061 0.95
57_L 202_I 1.059 0.95
55_K 61_Q 1.059 0.95
42_L 53_L 1.059 0.95
20_R 26_L 1.057 0.95
194_S 201_V 1.055 0.95
187_L 210_M 1.052 0.95
134_L 196_E 1.05 0.94
39_V 201_V 1.049 0.94
39_V 203_A 1.048 0.94
222_R 227_I 1.048 0.94
136_G 185_D 1.047 0.94
74_P 77_S 1.046 0.94
183_Q 210_M 1.034 0.94
189_L 192_R 1.028 0.94
193_L 199_L 1.027 0.94
56_M 68_I 1.009 0.93
131_A 163_A 1.008 0.93
30_L 53_L 1.007 0.93
130_E 165_D 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.98491000.07Contact Map0.873
1v43A10.96981000.074Contact Map0.821
2it1A20.94721000.075Contact Map0.862
3fvqA20.95851000.077Contact Map0.772
4g1uC20.97741000.077Contact Map0.744
2yyzA10.94721000.078Contact Map0.807
1g29120.95471000.078Contact Map0.888
4hziA20.99251000.079Contact Map0.862
1oxxK10.95471000.08Contact Map0.788
4mkiB20.96231000.081Contact Map0.806

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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