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FHUD - Iron(3+)-hydroxamate-binding protein FhuD
UniProt: P07822 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10305
Length: 296 (261)
Sequences: 5503
Seq/Len: 21.08

FHUD
Paralog alert: 0.76 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: BTUF FECB FEPB FHUD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
142_A 151_A 5.314 1.00
231_K 259_P 5.083 1.00
139_T 152_E 4.962 1.00
135_R 159_E 3.929 1.00
147_L 150_A 3.805 1.00
143_D 148_Q 3.582 1.00
259_P 263_A 3.354 1.00
40_A 46_V 3.105 1.00
156_A 160_D 2.989 1.00
139_T 155_L 2.975 1.00
152_E 156_A 2.883 1.00
201_L 206_I 2.772 1.00
37_R 57_Y 2.661 1.00
163_R 167_P 2.653 1.00
39_V 92_L 2.519 1.00
161_F 282_M 2.501 1.00
150_A 153_T 2.5 1.00
91_L 94_E 2.471 1.00
176_P 207_P 2.421 1.00
49_L 145_L 2.329 1.00
38_I 145_L 2.204 1.00
198_Q 202_D 2.176 1.00
153_T 157_Q 2.137 1.00
54_I 147_L 2.113 1.00
226_R 229_A 2.081 1.00
48_L 138_L 2.072 1.00
54_I 145_L 2.048 1.00
159_E 163_R 2.037 1.00
250_M 264_G 2.016 1.00
112_M 115_R 1.952 1.00
58_G 95_M 1.928 1.00
110_P 114_A 1.908 1.00
233_V 259_P 1.88 1.00
101_V 141_M 1.845 1.00
164_S 168_R 1.834 1.00
139_T 159_E 1.833 1.00
160_D 164_S 1.823 1.00
90_E 225_D 1.733 1.00
255_W 261_V 1.726 1.00
163_R 166_K 1.707 1.00
258_M 261_V 1.698 1.00
87_P 92_L 1.692 1.00
133_M 136_K 1.679 1.00
161_F 286_R 1.678 1.00
93_T 116_I 1.636 1.00
35_P 98_S 1.626 1.00
120_R 144_L 1.62 1.00
39_V 58_G 1.601 1.00
234_D 265_R 1.6 1.00
52_L 147_L 1.577 1.00
56_P 78_V 1.569 1.00
39_V 95_M 1.568 1.00
234_D 267_Q 1.558 1.00
40_A 49_L 1.532 1.00
136_K 139_T 1.51 1.00
149_S 153_T 1.507 1.00
111_E 115_R 1.492 1.00
36_N 98_S 1.45 1.00
209_A 230_Y 1.442 1.00
135_R 155_L 1.44 1.00
287_V 290_N 1.436 1.00
259_P 262_R 1.43 1.00
156_A 159_E 1.426 1.00
157_Q 161_F 1.42 1.00
100_M 117_A 1.387 0.99
148_Q 152_E 1.372 0.99
149_S 152_E 1.366 0.99
111_E 114_A 1.364 0.99
102_W 121_G 1.359 0.99
99_F 120_R 1.359 0.99
247_D 251_A 1.351 0.99
246_M 250_M 1.349 0.99
247_D 250_M 1.342 0.99
88_N 91_L 1.339 0.99
226_R 230_Y 1.336 0.99
136_K 140_E 1.336 0.99
120_R 140_E 1.303 0.99
177_L 206_I 1.3 0.99
157_Q 160_D 1.297 0.99
79_I 91_L 1.287 0.99
57_Y 95_M 1.28 0.99
38_I 99_F 1.274 0.99
255_W 258_M 1.252 0.99
150_A 154_H 1.248 0.99
140_E 144_L 1.233 0.98
51_A 154_H 1.226 0.98
257_A 262_R 1.211 0.98
167_P 170_V 1.21 0.98
37_R 96_K 1.204 0.98
155_L 159_E 1.199 0.98
49_L 101_V 1.188 0.98
176_P 233_V 1.184 0.98
50_L 56_P 1.178 0.98
49_L 56_P 1.168 0.97
285_V 289_D 1.162 0.97
100_M 116_I 1.15 0.97
235_V 260_F 1.136 0.97
154_H 157_Q 1.13 0.97
49_L 54_I 1.128 0.97
174_A 207_P 1.115 0.96
162_I 203_E 1.112 0.96
212_G 230_Y 1.11 0.96
164_S 167_P 1.09 0.96
93_T 117_A 1.07 0.95
161_F 165_M 1.067 0.95
45_P 101_V 1.058 0.95
244_K 247_D 1.055 0.95
58_G 82_G 1.05 0.94
224_I 252_T 1.05 0.94
138_L 151_A 1.048 0.94
228_A 258_M 1.048 0.94
160_D 163_R 1.046 0.94
282_M 286_R 1.042 0.94
259_P 265_R 1.041 0.94
169_F 172_R 1.034 0.94
210_W 230_Y 1.034 0.94
60_A 63_I 1.026 0.94
89_L 112_M 1.022 0.93
162_I 166_K 1.013 0.93
114_A 119_G 1.006 0.93
107_G 111_E 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1efdN10.89861000.332Contact Map0.684
3tefA10.93241000.366Contact Map0.733
2r7aA40.82771000.378Contact Map0.833
2r79A10.84461000.381Contact Map0.661
2q8pA10.83111000.385Contact Map0.769
3lhsA10.93921000.385Contact Map0.715
3tnyA10.96621000.387Contact Map0.749
4hn9A20.96961000.388Contact Map0.773
3md9A20.82431000.392Contact Map0.746
3mwfA10.91551000.393Contact Map0.758

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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