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ARAD - L-ribulose-5-phosphate 4-epimerase
UniProt: P08203 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10055
Length: 231 (220)
Sequences: 2865
Seq/Len: 13.02

ARAD
Paralog alert: 0.65 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: ARAD FUCA RHAD SGBE ULAF YGBL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
60_S 65_E 5.661 1.00
100_H 199_F 3.352 1.00
178_K 182_D 3.179 1.00
195_Y 199_F 2.869 1.00
39_F 81_R 2.68 1.00
40_V 56_M 2.596 1.00
109_Q 201_R 2.559 1.00
60_S 63_T 2.441 1.00
38_V 58_V 2.389 1.00
10_L 53_A 2.339 1.00
8_Q 181_E 2.29 1.00
7_R 11_E 2.179 1.00
143_W 147_N 2.094 1.00
38_V 67_V 2.078 1.00
90_I 176_W 2.07 1.00
99_R 195_Y 1.882 1.00
165_G 190_L 1.874 1.00
100_H 195_Y 1.865 1.00
179_N 182_D 1.864 1.00
211_Q 214_L 1.842 1.00
100_H 198_I 1.84 1.00
103_I 199_F 1.836 1.00
94_V 183_A 1.801 1.00
212_Q 216_D 1.801 1.00
92_G 180_A 1.785 1.00
5_L 31_A 1.783 1.00
91_G 179_N 1.78 1.00
63_T 85_Q 1.769 1.00
31_A 180_A 1.762 1.00
82_L 147_N 1.713 1.00
52_T 55_D 1.694 1.00
82_L 86_A 1.688 1.00
40_V 58_V 1.633 1.00
10_L 14_L 1.62 1.00
173_P 190_L 1.614 1.00
7_R 53_A 1.59 1.00
33_D 40_V 1.541 1.00
104_W 201_R 1.521 1.00
127_P 156_Q 1.493 1.00
89_S 161_A 1.479 1.00
213_T 217_K 1.444 1.00
98_S 101_A 1.428 1.00
108_G 169_H 1.427 1.00
199_F 202_Q 1.42 1.00
82_L 85_Q 1.417 1.00
15_A 19_H 1.397 0.99
101_A 173_P 1.386 0.99
175_A 187_A 1.37 0.99
4_D 8_Q 1.362 0.99
9_V 29_V 1.353 0.99
14_L 18_K 1.351 0.99
81_R 85_Q 1.338 0.99
39_F 61_I 1.335 0.99
95_H 171_H 1.329 0.99
165_G 175_A 1.319 0.99
177_G 182_D 1.317 0.99
99_R 103_I 1.308 0.99
147_N 151_E 1.286 0.99
96_T 187_A 1.285 0.99
59_V 77_T 1.267 0.99
19_H 188_I 1.251 0.99
173_P 187_A 1.247 0.99
86_A 154_E 1.245 0.98
110_S 128_C 1.243 0.98
31_A 92_G 1.237 0.98
151_E 154_E 1.233 0.98
9_V 56_M 1.231 0.98
111_I 194_A 1.228 0.98
102_T 105_A 1.226 0.98
107_A 203_L 1.224 0.98
87_F 90_I 1.215 0.98
198_I 202_Q 1.196 0.98
110_S 125_T 1.177 0.98
86_A 150_V 1.171 0.98
149_I 168_V 1.171 0.98
191_E 195_Y 1.17 0.97
97_H 171_H 1.17 0.97
51_M 55_D 1.165 0.97
197_G 201_R 1.154 0.97
16_L 184_V 1.141 0.97
12_A 184_V 1.138 0.97
177_G 186_N 1.121 0.97
192_E 195_Y 1.119 0.96
110_S 156_Q 1.119 0.96
83_L 90_I 1.118 0.96
99_R 199_F 1.116 0.96
6_K 68_E 1.112 0.96
2_L 38_V 1.105 0.96
79_T 174_F 1.094 0.96
198_I 203_L 1.086 0.96
33_D 58_V 1.084 0.96
60_S 67_V 1.067 0.95
210_M 214_L 1.067 0.95
16_L 94_V 1.053 0.95
148_V 151_E 1.052 0.95
162_Q 219_Y 1.043 0.94
153_F 166_V 1.039 0.94
130_R 169_H 1.035 0.94
168_V 174_F 1.034 0.94
112_P 197_G 1.033 0.94
66_V 69_G 1.032 0.94
83_L 153_F 1.031 0.94
15_A 18_K 1.03 0.94
55_D 71_K 1.017 0.93
130_R 151_E 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1k0wA611000.083Contact Map0.808
1e4cP10.90481000.137Contact Map0.715
3ocrA20.93941000.171Contact Map0.689
2opiA20.88741000.181Contact Map0.685
2v9lA10.93511000.197Contact Map0.628
2z7bA10.93511000.201Contact Map0.7
1pvtA10.86581000.204Contact Map0.563
2fk5A20.83121000.21Contact Map0.649
2irpA20.82681000.237Contact Map0.726
3m4rA10.78351000.327Contact Map0.617

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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