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ARAB - Ribulokinase
UniProt: P08204 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10053
Length: 566 (519)
Sequences: 5078
Seq/Len: 9.78

ARAB
Paralog alert: 0.73 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: ARAB FUCK GLPK LSRK LYXK RHAB XYLB YGCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
20_D 25_E 4.622 1.00
220_A 236_S 4.506 1.00
127_E 165_R 4.053 1.00
439_R 443_E 3.302 1.00
439_R 536_Y 3.233 1.00
130_E 165_R 3.198 1.00
470_Q 474_D 3.195 1.00
414_I 426_L 3.187 1.00
16_A 64_A 3.097 1.00
18_A 68_V 3.072 1.00
102_L 170_V 2.987 1.00
244_T 247_I 2.983 1.00
211_H 219_P 2.824 1.00
506_D 509_S 2.71 1.00
439_R 533_E 2.707 1.00
479_P 523_Q 2.707 1.00
20_D 23_T 2.682 1.00
446_T 478_R 2.664 1.00
96_D 173_S 2.65 1.00
55_R 187_L 2.614 1.00
211_H 214_W 2.606 1.00
385_N 425_L 2.585 1.00
32_E 67_T 2.583 1.00
341_I 430_L 2.575 1.00
505_A 509_S 2.564 1.00
185_P 271_G 2.561 1.00
7_L 61_M 2.544 1.00
93_A 180_L 2.541 1.00
223_F 236_S 2.539 1.00
216_G 236_S 2.511 1.00
103_A 167_D 2.491 1.00
189_S 268_I 2.478 1.00
30_S 67_T 2.371 1.00
466_Q 520_K 2.338 1.00
32_E 63_A 2.325 1.00
37_W 115_M 2.32 1.00
13_S 31_V 2.319 1.00
55_R 100_N 2.265 1.00
58_I 187_L 2.235 1.00
97_A 175_A 2.222 1.00
210_W 242_T 2.216 1.00
269_S 500_A 2.151 1.00
297_T 338_F 2.148 1.00
17_L 490_A 2.144 1.00
5_I 16_A 2.14 1.00
62_E 259_R 2.139 1.00
272_A 277_M 2.133 1.00
35_P 56_D 2.105 1.00
446_T 451_A 2.046 1.00
220_A 224_D 2.026 1.00
394_V 414_I 2.006 1.00
384_K 424_P 1.978 1.00
9_F 14_V 1.954 1.00
454_N 481_Q 1.952 1.00
525_C 528_Q 1.943 1.00
248_P 269_S 1.937 1.00
536_Y 540_Q 1.927 1.00
390_H 425_L 1.906 1.00
428_G 432_A 1.885 1.00
254_P 258_Q 1.885 1.00
467_V 471_A 1.864 1.00
146_Y 219_P 1.839 1.00
477_N 529_A 1.829 1.00
393_V 538_R 1.812 1.00
75_E 78_A 1.805 1.00
46_P 49_Q 1.79 1.00
3_I 27_I 1.779 1.00
253_C 256_W 1.769 1.00
146_Y 221_S 1.763 1.00
191_T 241_D 1.75 1.00
377_A 380_E 1.744 1.00
189_S 250_G 1.74 1.00
18_A 74_V 1.731 1.00
5_I 65_L 1.725 1.00
94_P 238_L 1.717 1.00
243_W 247_I 1.714 1.00
161_L 165_R 1.711 1.00
99_G 186_A 1.7 1.00
417_L 421_T 1.676 1.00
443_E 446_T 1.674 1.00
407_N 547_E 1.661 1.00
126_E 130_E 1.657 1.00
142_D 146_Y 1.649 1.00
422_D 425_L 1.641 1.00
457_A 469_M 1.635 1.00
67_T 71_E 1.63 1.00
466_Q 522_L 1.63 1.00
466_Q 482_I 1.62 1.00
474_D 525_C 1.6 1.00
142_D 145_R 1.595 1.00
4_A 498_A 1.589 1.00
129_E 133_R 1.587 1.00
183_W 187_L 1.56 1.00
68_V 72_L 1.552 1.00
82_G 497_A 1.55 1.00
254_P 264_E 1.549 1.00
436_F 535_L 1.541 1.00
394_V 398_F 1.537 1.00
479_P 521_T 1.532 1.00
130_E 134_L 1.531 1.00
28_A 68_V 1.522 1.00
379_T 465_N 1.514 1.00
382_W 467_V 1.506 1.00
53_H 56_D 1.503 1.00
481_Q 521_T 1.495 1.00
248_P 251_T 1.492 1.00
394_V 430_L 1.49 1.00
378_L 427_F 1.484 1.00
169_A 172_Q 1.48 1.00
381_A 424_P 1.48 1.00
14_V 61_M 1.463 1.00
272_A 496_F 1.453 1.00
18_A 72_L 1.453 1.00
381_A 384_K 1.446 1.00
392_P 421_T 1.445 1.00
89_G 273_F 1.445 1.00
14_V 60_S 1.427 1.00
288_A 456_M 1.422 1.00
482_I 522_L 1.418 1.00
484_A 517_A 1.416 0.99
289_L 452_V 1.416 0.99
291_K 472_C 1.412 0.99
474_D 528_Q 1.401 0.99
94_P 163_V 1.387 0.99
91_T 116_F 1.374 0.99
412_G 417_L 1.374 0.99
288_A 454_N 1.363 0.99
435_A 471_A 1.363 0.99
377_A 381_A 1.36 0.99
162_H 166_Q 1.354 0.99
293_I 472_C 1.354 0.99
345_F 430_L 1.352 0.99
335_Q 437_G 1.344 0.99
529_A 533_E 1.343 0.99
127_E 161_L 1.343 0.99
30_S 68_V 1.341 0.99
30_S 64_A 1.337 0.99
388_L 391_L 1.324 0.99
132_T 140_N 1.322 0.99
443_E 540_Q 1.319 0.99
58_I 62_E 1.318 0.99
484_A 519_E 1.318 0.99
3_I 18_A 1.318 0.99
471_A 475_V 1.309 0.99
413_V 546_A 1.298 0.99
380_E 384_K 1.295 0.99
54_P 115_M 1.295 0.99
337_A 340_D 1.293 0.99
411_K 418_N 1.291 0.99
18_A 80_V 1.287 0.99
286_P 304_D 1.287 0.99
7_L 65_L 1.284 0.99
4_A 503_V 1.283 0.99
263_P 266_V 1.282 0.99
454_N 479_P 1.281 0.99
141_V 145_R 1.28 0.99
443_E 536_Y 1.277 0.99
142_D 221_S 1.276 0.99
157_W 226_L 1.276 0.99
94_P 160_I 1.274 0.99
379_T 383_A 1.263 0.99
541_Q 545_S 1.259 0.99
28_A 72_L 1.258 0.99
69_L 80_V 1.257 0.99
498_A 504_H 1.249 0.98
243_W 249_V 1.247 0.98
164_T 171_A 1.245 0.98
55_R 59_E 1.238 0.98
96_D 100_N 1.235 0.98
170_V 173_S 1.231 0.98
185_P 249_V 1.219 0.98
83_I 266_V 1.217 0.98
374_L 377_A 1.217 0.98
21_C 503_V 1.211 0.98
169_A 173_S 1.21 0.98
248_P 267_V 1.206 0.98
469_M 522_L 1.205 0.98
391_L 428_G 1.204 0.98
435_A 475_V 1.204 0.98
57_Y 180_L 1.202 0.98
7_L 16_A 1.196 0.98
74_V 79_A 1.195 0.98
470_Q 522_L 1.191 0.98
142_D 225_E 1.185 0.98
248_P 500_A 1.184 0.98
3_I 79_A 1.183 0.98
95_I 178_I 1.182 0.98
434_T 461_I 1.181 0.98
341_I 394_V 1.173 0.97
195_Q 318_G 1.172 0.97
251_T 265_S 1.168 0.97
163_V 170_V 1.165 0.97
343_A 347_R 1.164 0.97
61_M 65_L 1.162 0.97
128_A 151_Y 1.155 0.97
66_K 70_A 1.149 0.97
298_C 334_G 1.146 0.97
544_M 547_E 1.146 0.97
59_E 63_A 1.145 0.97
210_W 214_W 1.142 0.97
289_L 455_V 1.137 0.97
216_G 241_D 1.135 0.97
439_R 476_L 1.135 0.97
61_M 184_V 1.132 0.97
103_A 163_V 1.131 0.97
63_A 67_T 1.129 0.97
252_L 266_V 1.125 0.96
518_V 521_T 1.125 0.96
92_P 177_W 1.125 0.96
34_Y 60_S 1.123 0.96
382_W 428_G 1.12 0.96
194_P 319_Q 1.117 0.96
82_G 269_S 1.116 0.96
125_V 129_E 1.113 0.96
414_I 430_L 1.107 0.96
275_C 298_C 1.106 0.96
19_V 26_E 1.101 0.96
385_N 389_D 1.096 0.96
379_T 466_Q 1.096 0.96
127_E 166_Q 1.094 0.96
435_A 472_C 1.094 0.96
69_L 72_L 1.093 0.96
464_K 486_D 1.091 0.96
381_A 427_F 1.091 0.96
442_M 476_L 1.091 0.96
171_A 174_A 1.09 0.96
440_A 540_Q 1.089 0.96
122_H 152_S 1.087 0.95
161_L 171_A 1.08 0.95
50_F 120_K 1.079 0.95
380_E 383_A 1.076 0.95
28_A 71_E 1.071 0.95
216_G 220_A 1.068 0.95
36_R 52_H 1.061 0.95
96_D 102_L 1.055 0.94
337_A 341_I 1.055 0.94
527_E 530_Q 1.046 0.94
285_Q 288_A 1.044 0.94
126_E 129_E 1.044 0.94
269_S 501_A 1.037 0.94
2_A 79_A 1.036 0.94
5_I 18_A 1.034 0.94
123_T 162_H 1.032 0.94
102_L 173_S 1.029 0.93
128_A 158_A 1.029 0.93
37_W 56_D 1.025 0.93
9_F 60_S 1.023 0.93
161_L 227_D 1.02 0.93
174_A 238_L 1.019 0.93
54_P 93_A 1.016 0.93
66_K 259_R 1.014 0.93
319_Q 327_G 1.013 0.93
533_E 537_R 1.001 0.92
251_T 267_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3jvpA40.95581000.189Contact Map0.753
3ifrA20.88341000.19Contact Map0.74
3hz6A10.87281000.195Contact Map0.629
3ll3A20.88161000.201Contact Map0.752
2itmA20.84631000.215Contact Map0.777
3l0qA20.92231000.231Contact Map0.747
2w40A40.85511000.239Contact Map0.758
2p3rA80.86571000.24Contact Map0.869
2d4wA20.86221000.241Contact Map0.795
2zf5O20.85871000.242Contact Map0.847

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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