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CPDB - 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
UniProt: P08331 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10160
Length: 647 (624)
Sequences: 715
Seq/Len: 1.15

CPDB
Paralog alert: 0.20 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: CPDB USHA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
60_N 334_D 3.733 1.00
357_G 575_I 3.478 1.00
498_Q 523_N 3.047 1.00
211_E 215_K 2.877 1.00
213_R 220_V 2.771 1.00
532_D 535_A 2.633 1.00
448_K 536_M 2.599 1.00
179_V 205_V 2.562 1.00
30_T 288_P 2.555 1.00
252_A 298_V 2.509 0.99
499_I 521_I 2.459 0.99
452_K 456_E 2.451 0.99
158_K 176_Y 2.314 0.99
222_V 250_V 2.231 0.99
524_L 531_I 2.224 0.99
72_V 176_Y 2.209 0.98
175_G 212_M 2.194 0.98
247_I 250_V 2.141 0.98
383_Q 404_S 2.124 0.98
29_T 109_Y 2.115 0.98
26_I 221_V 2.085 0.97
209_V 249_G 2.064 0.97
112_G 135_F 2.032 0.97
26_I 254_M 2.03 0.97
454_V 531_I 2.028 0.97
28_E 254_M 2.022 0.97
70_V 174_I 2.007 0.97
455_K 533_P 2.006 0.97
72_V 111_V 1.978 0.96
175_G 217_A 1.961 0.96
342_K 346_D 1.929 0.96
450_S 453_E 1.906 0.95
355_P 428_Q 1.856 0.94
157_I 173_K 1.845 0.94
219_V 302_L 1.83 0.94
209_V 247_I 1.824 0.93
71_L 109_Y 1.793 0.93
28_E 296_G 1.732 0.91
496_N 525_T 1.732 0.91
144_D 147_T 1.725 0.91
356_I 575_I 1.706 0.90
449_A 539_V 1.698 0.90
335_S 339_E 1.674 0.89
56_A 107_L 1.668 0.89
459_E 520_R 1.662 0.88
199_N 204_T 1.648 0.88
28_E 74_N 1.644 0.88
217_A 220_V 1.626 0.87
55_T 295_L 1.616 0.86
155_Y 208_Y 1.599 0.86
24_L 176_Y 1.597 0.86
172_L 219_V 1.596 0.86
55_T 59_I 1.583 0.85
358_K 428_Q 1.581 0.85
205_V 250_V 1.577 0.85
205_V 247_I 1.573 0.84
490_D 545_R 1.573 0.84
212_M 217_A 1.56 0.84
380_N 406_A 1.56 0.84
500_D 503_Q 1.55 0.83
210_P 214_E 1.547 0.83
208_Y 211_E 1.531 0.82
449_A 454_V 1.526 0.82
302_L 311_V 1.518 0.81
455_K 524_L 1.51 0.81
566_E 569_S 1.5 0.80
446_V 538_L 1.494 0.80
252_A 284_P 1.491 0.80
57_S 61_D 1.487 0.79
85_D 441_P 1.481 0.79
106_T 340_T 1.476 0.79
284_P 314_A 1.468 0.78
449_A 453_E 1.453 0.77
356_I 434_A 1.442 0.77
525_T 530_P 1.441 0.76
72_V 223_L 1.435 0.76
387_V 540_A 1.429 0.76
503_Q 522_K 1.428 0.76
454_V 535_A 1.423 0.75
120_N 188_D 1.422 0.75
292_G 295_L 1.421 0.75
438_Y 490_D 1.418 0.75
111_V 176_Y 1.417 0.75
53_V 337_L 1.404 0.74
104_L 135_F 1.398 0.73
58_L 295_L 1.396 0.73
493_D 590_D 1.383 0.72
176_Y 221_V 1.367 0.71
448_K 538_L 1.365 0.71
455_K 521_I 1.365 0.71
508_D 512_Q 1.365 0.71
542_N 545_R 1.362 0.71
63_R 108_D 1.351 0.70
456_E 507_Y 1.347 0.69
629_N 642_Q 1.346 0.69
429_L 575_I 1.334 0.68
442_N 542_N 1.327 0.68
498_Q 594_R 1.324 0.67
459_E 518_A 1.324 0.67
452_K 533_P 1.32 0.67
79_Q 257_H 1.318 0.67
143_I 199_N 1.318 0.67
33_H 257_H 1.318 0.67
227_G 257_H 1.315 0.67
56_A 60_N 1.314 0.67
219_V 300_L 1.307 0.66
202_T 206_R 1.303 0.66
503_Q 519_E 1.301 0.65
221_V 335_S 1.298 0.65
387_V 446_V 1.293 0.65
70_V 158_K 1.29 0.64
34_S 84_A 1.288 0.64
30_T 439_L 1.285 0.64
258_A 287_M 1.278 0.63
62_A 65_E 1.277 0.63
101_Y 133_A 1.277 0.63
154_P 208_Y 1.277 0.63
71_L 295_L 1.27 0.63
532_D 537_F 1.265 0.62
66_V 69_S 1.264 0.62
29_T 71_L 1.261 0.62
289_G 293_D 1.261 0.62
63_R 71_L 1.26 0.62
159_D 167_G 1.256 0.61
128_N 132_G 1.254 0.61
154_P 383_Q 1.254 0.61
569_S 572_A 1.252 0.61
286_V 521_I 1.251 0.61
79_Q 544_Y 1.251 0.61
32_L 52_L 1.248 0.61
500_D 522_K 1.247 0.61
506_R 513_M 1.246 0.60
163_V 169_K 1.243 0.60
357_G 569_S 1.237 0.60
56_A 337_L 1.237 0.60
578_E 583_G 1.232 0.59
32_L 292_G 1.231 0.59
33_H 227_G 1.229 0.59
569_S 573_A 1.229 0.59
450_S 536_M 1.225 0.59
245_S 281_N 1.223 0.58
573_A 577_D 1.216 0.58
25_R 297_V 1.213 0.57
187_W 545_R 1.211 0.57
431_F 572_A 1.21 0.57
362_N 426_K 1.209 0.57
185_M 198_V 1.208 0.57
143_I 150_P 1.203 0.56
464_Q 486_T 1.2 0.56
568_R 593_W 1.198 0.56
147_T 429_L 1.198 0.56
508_D 514_I 1.198 0.56
209_V 220_V 1.195 0.56
113_T 223_L 1.194 0.56
58_L 319_R 1.192 0.55
458_L 521_I 1.192 0.55
475_P 640_I 1.189 0.55
199_N 207_K 1.187 0.55
354_K 576_A 1.182 0.54
23_D 301_Q 1.181 0.54
187_W 490_D 1.18 0.54
158_K 174_I 1.18 0.54
241_V 255_F 1.178 0.54
496_N 592_N 1.174 0.54
452_K 455_K 1.169 0.53
224_A 255_F 1.165 0.53
213_R 249_G 1.164 0.53
44_D 432_R 1.162 0.53
111_V 138_V 1.158 0.52
200_D 203_E 1.157 0.52
71_L 107_L 1.154 0.52
73_D 79_Q 1.149 0.51
355_P 430_T 1.148 0.51
133_A 140_A 1.148 0.51
462_A 499_I 1.146 0.51
27_M 521_I 1.144 0.51
206_R 246_E 1.142 0.51
105_N 135_F 1.141 0.51
172_L 302_L 1.138 0.50
62_A 297_V 1.138 0.50
207_K 211_E 1.138 0.50
452_K 534_N 1.129 0.49
79_Q 490_D 1.129 0.49
56_A 334_D 1.127 0.49
177_I 212_M 1.125 0.49
337_L 340_T 1.124 0.49
79_Q 259_H 1.122 0.49
22_V 162_V 1.122 0.49
254_M 298_V 1.121 0.49
345_H 349_R 1.121 0.49
162_V 170_Q 1.12 0.49
210_P 247_I 1.119 0.48
63_R 500_D 1.117 0.48
25_R 62_A 1.116 0.48
25_R 299_D 1.114 0.48
539_V 578_E 1.113 0.48
72_V 158_K 1.111 0.48
203_E 206_R 1.111 0.48
222_V 502_T 1.11 0.48
159_D 339_E 1.11 0.48
45_T 174_I 1.108 0.47
454_V 537_F 1.106 0.47
35_N 81_S 1.105 0.47
33_H 79_Q 1.104 0.47
168_K 516_A 1.1 0.47
438_Y 545_R 1.099 0.46
279_T 532_D 1.097 0.46
212_M 220_V 1.096 0.46
79_Q 545_R 1.094 0.46
27_M 295_L 1.093 0.46
351_F 431_F 1.091 0.46
384_K 493_D 1.087 0.45
159_D 174_I 1.084 0.45
353_S 432_R 1.083 0.45
425_E 452_K 1.083 0.45
359_S 362_N 1.082 0.45
159_D 211_E 1.082 0.45
74_N 307_G 1.08 0.45
624_G 632_A 1.08 0.45
187_W 488_N 1.079 0.45
376_V 406_A 1.079 0.45
142_V 180_V 1.078 0.44
107_L 202_T 1.078 0.44
26_I 70_V 1.078 0.44
487_Y 585_I 1.078 0.44
241_V 253_I 1.076 0.44
117_H 225_H 1.076 0.44
346_D 350_Q 1.075 0.44
217_A 300_L 1.074 0.44
503_Q 518_A 1.073 0.44
187_W 442_N 1.069 0.44
415_K 544_Y 1.067 0.43
139_N 180_V 1.065 0.43
404_S 545_R 1.064 0.43
487_Y 490_D 1.064 0.43
617_A 630_K 1.063 0.43
252_A 314_A 1.062 0.43
147_T 150_P 1.062 0.43
252_A 311_V 1.061 0.43
64_N 335_S 1.059 0.43
25_R 67_K 1.059 0.43
453_E 558_H 1.058 0.43
101_Y 337_L 1.056 0.42
209_V 250_V 1.056 0.42
79_Q 227_G 1.055 0.42
140_A 154_P 1.055 0.42
383_Q 542_N 1.054 0.42
454_V 486_T 1.053 0.42
113_T 138_V 1.053 0.42
23_D 299_D 1.051 0.42
200_D 240_S 1.049 0.42
369_L 486_T 1.045 0.41
633_T 636_I 1.043 0.41
454_V 532_D 1.041 0.41
118_E 443_T 1.041 0.41
440_Y 544_Y 1.04 0.41
138_V 285_A 1.039 0.41
221_V 252_A 1.039 0.41
603_K 617_A 1.034 0.40
454_V 530_P 1.034 0.40
384_K 388_E 1.033 0.40
624_G 644_D 1.032 0.40
150_P 208_Y 1.029 0.40
157_I 217_A 1.028 0.40
466_N 480_N 1.028 0.40
222_V 253_I 1.028 0.40
337_L 341_L 1.022 0.39
225_H 257_H 1.022 0.39
610_T 628_M 1.022 0.39
434_A 571_L 1.02 0.39
256_G 288_P 1.019 0.39
250_V 253_I 1.018 0.39
160_T 502_T 1.018 0.39
112_G 136_P 1.018 0.39
498_Q 596_A 1.015 0.39
363_M 465_F 1.014 0.39
333_E 338_V 1.013 0.38
295_L 521_I 1.01 0.38
457_W 541_T 1.009 0.38
253_I 318_A 1.008 0.38
120_N 184_I 1.008 0.38
365_S 373_D 1.007 0.38
101_Y 129_A 1.006 0.38
51_G 80_G 1.004 0.38
136_P 458_L 1.004 0.38
465_F 490_D 1.003 0.38
205_V 208_Y 1.002 0.37
607_R 640_I 1.001 0.37
323_D 327_K 1.001 0.37
182_P 201_I 1 0.37
33_H 259_H 1 0.37
506_R 519_E 1 0.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2z1aA10.8131000.469Contact Map0.64
3qfkA10.79291000.47Contact Map0.603
4h2gA10.79131000.481Contact Map0.658
3ztvA10.78671000.484Contact Map0.616
3iveA10.7621000.484Contact Map0.646
1hp1A10.7621000.506Contact Map0.664
2wdcA10.77591000.506Contact Map0.603
3jyfA20.5241000.617Contact Map0.748
3c9fA20.78211000.623Contact Map0.445
3gveA20.51781000.629Contact Map0.702

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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