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CHPS - Antitoxin ChpS
UniProt: P08365 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11250
Length: 83 (83)
Sequences: 277
Seq/Len: 3.34

CHPS
Paralog alert: 0.39 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: CHPS MAZE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
12_A 21_M 3.546 1.00
8_W 15_V 2.806 1.00
32_V 43_L 2.412 1.00
60_D 63_A 2.268 1.00
59_C 63_A 2.039 1.00
16_I 21_M 1.934 1.00
40_Q 44_T 1.904 1.00
52_L 56_L 1.88 0.99
6_K 29_G 1.763 0.99
8_W 11_S 1.66 0.98
8_W 13_G 1.625 0.98
12_A 28_P 1.603 0.98
18_N 22_K 1.538 0.97
10_N 15_V 1.518 0.97
37_S 40_Q 1.512 0.97
30_Q 45_P 1.405 0.94
21_M 28_P 1.362 0.93
11_S 15_V 1.359 0.93
10_N 13_G 1.351 0.93
50_Y 55_L 1.345 0.93
24_L 41_L 1.315 0.91
73_G 83_W 1.265 0.89
14_M 32_V 1.227 0.87
34_A 57_A 1.19 0.85
56_L 59_C 1.173 0.84
6_K 15_V 1.171 0.84
5_I 12_A 1.151 0.82
29_G 49_R 1.137 0.81
30_Q 67_S 1.104 0.78
14_M 41_L 1.102 0.78
55_L 58_Q 1.083 0.76
66_L 69_Q 1.062 0.74
1_M 10_N 1.054 0.74
21_M 24_L 1.05 0.73
6_K 30_Q 1.042 0.72
68_E 72_W 1.033 0.71
36_V 39_N 1.017 0.70
7_R 39_N 1.009 0.69
69_Q 73_G 1.009 0.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1mvfD20.951899.80.27Contact Map0.642
3zvkE40.891699.20.519Contact Map0.572
3tndB40.879598.90.576Contact Map0.516
3o27A20.626598.60.616Contact Map0.498
1yfbA20.590498.20.661Contact Map0.385
2l66A20.614597.60.702Contact Map0.459
2w1tA10.963996.30.752Contact Map0.261
2glwA10.530140.10.873Contact Map0.245
1fr3A120.542222.70.887Contact Map0.314
3d31A20.530122.30.888Contact Map0.178

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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