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CREB - Transcriptional regulatory protein CreB
UniProt: P08368 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11218
Length: 229 (223)
Sequences: 27767
Seq/Len: 124.52

CREB
Paralog alert: 0.94 [within 20: 0.55] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
16_A 32_V 3.476 1.00
16_A 34_E 2.781 1.00
37_L 59_D 2.567 1.00
9_V 39_V 2.476 1.00
20_V 32_V 2.47 1.00
35_R 59_D 2.45 1.00
158_Y 161_L 2.4 1.00
193_R 196_D 2.396 1.00
176_R 196_D 2.389 1.00
31_E 48_P 2.335 1.00
60_I 68_Q 2.314 1.00
159_E 205_K 2.298 1.00
20_V 24_Q 2.258 1.00
87_E 107_S 2.243 1.00
36_G 60_I 2.173 1.00
90_R 110_E 2.101 1.00
35_R 38_P 2.074 1.00
44_R 73_H 2.014 1.00
5_T 29_A 1.988 1.00
40_L 68_Q 1.962 1.00
22_M 108_P 1.957 1.00
136_H 149_F 1.956 1.00
133_R 138_E 1.894 1.00
61_S 64_E 1.882 1.00
217_N 227_R 1.842 1.00
164_K 168_K 1.831 1.00
34_E 38_P 1.809 1.00
145_Q 152_P 1.8 1.00
80_F 93_G 1.787 1.00
198_H 201_T 1.78 1.00
5_T 31_E 1.763 1.00
50_V 115_V 1.742 1.00
33_F 42_K 1.734 1.00
79_L 118_L 1.72 1.00
217_N 225_S 1.716 1.00
23_L 115_V 1.705 1.00
66_C 78_V 1.693 1.00
55_V 80_F 1.67 1.00
165_T 179_L 1.664 1.00
99_D 121_R 1.648 1.00
95_E 116_R 1.625 1.00
56_G 84_R 1.614 1.00
53_L 66_C 1.607 1.00
139_L 167_L 1.598 1.00
53_L 65_L 1.598 1.00
138_E 147_S 1.574 1.00
169_S 172_R 1.554 1.00
7_W 33_F 1.551 1.00
68_Q 72_L 1.536 1.00
84_R 89_D 1.509 1.00
66_C 80_F 1.483 1.00
9_V 57_L 1.478 1.00
165_T 182_S 1.477 1.00
51_M 76_L 1.465 1.00
175_S 178_Q 1.455 1.00
80_F 98_A 1.441 1.00
26_E 112_C 1.43 1.00
36_G 65_L 1.427 1.00
10_E 16_A 1.393 0.99
40_L 65_L 1.382 0.99
60_I 64_E 1.369 0.99
63_F 96_I 1.367 0.99
31_E 42_K 1.365 0.99
71_A 99_D 1.363 0.99
64_E 67_R 1.307 0.99
199_I 203_R 1.296 0.99
68_Q 73_H 1.29 0.99
140_N 143_A 1.285 0.99
100_D 114_R 1.283 0.99
170_P 174_W 1.278 0.99
55_V 63_F 1.273 0.99
37_L 60_I 1.268 0.99
41_D 45_K 1.254 0.99
42_K 45_K 1.252 0.99
219_H 225_S 1.229 0.98
42_K 46_Q 1.228 0.98
165_T 174_W 1.22 0.98
27_G 116_R 1.206 0.98
28_F 116_R 1.202 0.98
174_W 182_S 1.176 0.98
40_L 60_I 1.164 0.97
144_A 161_L 1.164 0.97
50_V 119_L 1.163 0.97
86_E 89_D 1.162 0.97
131_V 138_E 1.16 0.97
33_F 39_V 1.15 0.97
37_L 41_D 1.148 0.97
43_A 70_L 1.138 0.97
38_P 41_D 1.135 0.97
118_L 121_R 1.132 0.97
144_A 222_M 1.118 0.96
194_T 198_H 1.116 0.96
172_R 178_Q 1.116 0.96
147_S 152_P 1.112 0.96
141_E 164_K 1.108 0.96
156_T 205_K 1.104 0.96
139_L 160_F 1.098 0.96
13_Q 34_E 1.097 0.96
197_T 200_K 1.097 0.96
67_R 92_L 1.085 0.96
11_D 54_D 1.084 0.96
6_V 28_F 1.077 0.95
158_Y 184_W 1.075 0.95
177_Q 192_D 1.074 0.95
88_V 92_L 1.069 0.95
7_W 39_V 1.061 0.95
31_E 46_Q 1.06 0.95
7_W 48_P 1.057 0.95
56_G 83_A 1.05 0.94
39_V 43_A 1.049 0.94
177_Q 181_D 1.046 0.94
9_V 51_M 1.045 0.94
63_F 92_L 1.045 0.94
38_P 42_K 1.041 0.94
19_L 81_L 1.041 0.94
57_L 65_L 1.04 0.94
87_E 91_L 1.034 0.94
91_L 109_R 1.033 0.94
142_P 172_R 1.032 0.94
134_I 226_L 1.029 0.94
8_L 30_V 1.025 0.93
117_T 122_V 1.025 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2gwrA10.98691000.095Contact Map0.678
1ys7A20.99131000.109Contact Map0.776
2oqrA10.99131000.113Contact Map0.575
3r0jA20.98691000.114Contact Map0.685
4b09A120.99561000.144Contact Map0.679
1kgsA10.97821000.145Contact Map0.714
1p2fA10.94761000.167Contact Map0.743
2hqrA20.93891000.17Contact Map0.677
3q9sA10.93891000.176Contact Map0.682
3c3wA20.92141000.282Contact Map0.629

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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