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PHOR - Phosphate regulon sensor protein PhoR
UniProt: P08400 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10733
Length: 431 (358)
Sequences: 9441
Seq/Len: 26.37

PHOR
Paralog alert: 0.78 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: ATOS BAES BASS CPXA CREC CUSS DCUS DPIB ENVZ GLRK NTRB PHOQ PHOR QSEC RSTB YEDV ZRAS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
226_L 246_M 3.796 1.00
109_D 192_R 3.707 1.00
333_T 357_N 3.005 1.00
410_T 413_K 2.975 1.00
406_N 418_S 2.903 1.00
355_E 416_R 2.829 1.00
278_V 313_G 2.681 1.00
366_I 407_I 2.641 1.00
395_K 399_N 2.518 1.00
112_V 189_M 2.455 1.00
362_A 365_H 2.386 1.00
394_V 405_L 2.364 1.00
97_I 101_R 2.356 1.00
104_A 122_W 2.333 1.00
110_A 130_I 2.306 1.00
407_I 417_F 2.298 1.00
351_E 418_S 2.242 1.00
115_T 119_G 2.218 1.00
276_E 315_E 2.209 1.00
304_E 342_R 2.171 1.00
342_R 353_S 2.164 1.00
321_A 398_V 2.151 1.00
361_I 365_H 2.14 1.00
279_D 282_M 2.137 1.00
352_F 419_F 2.129 1.00
277_K 312_S 2.106 1.00
302_T 338_H 2.104 1.00
230_N 244_H 2.089 1.00
223_Q 250_T 2.073 1.00
110_A 191_A 2.058 1.00
353_S 416_R 2.031 1.00
230_N 247_R 2.027 1.00
351_E 420_V 2.022 1.00
126_L 129_Q 1.973 1.00
398_V 419_F 1.967 1.00
313_G 401_H 1.964 1.00
342_R 355_E 1.953 1.00
340_T 355_E 1.932 1.00
321_A 394_V 1.928 1.00
96_L 99_R 1.914 1.00
353_S 418_S 1.862 1.00
344_Q 351_E 1.852 1.00
321_A 397_A 1.829 1.00
286_V 319_R 1.828 1.00
125_G 129_Q 1.818 1.00
101_R 105_E 1.811 1.00
112_V 120_I 1.805 1.00
107_L 111_V 1.804 1.00
86_N 90_R 1.801 1.00
141_Q 145_N 1.794 1.00
281_P 343_W 1.779 1.00
370_T 405_L 1.755 1.00
300_T 338_H 1.749 1.00
304_E 340_T 1.734 1.00
349_G 420_V 1.719 1.00
176_E 192_R 1.715 1.00
333_T 339_I 1.669 1.00
362_A 411_V 1.667 1.00
361_I 369_L 1.665 1.00
128_Q 135_W 1.658 1.00
302_T 340_T 1.647 1.00
363_P 366_I 1.646 1.00
313_G 318_L 1.614 1.00
112_V 127_A 1.603 1.00
344_Q 353_S 1.601 1.00
345_R 423_E 1.597 1.00
100_F 104_A 1.589 1.00
366_I 409_S 1.588 1.00
409_S 415_T 1.581 1.00
123_C 127_A 1.575 1.00
223_Q 251_Q 1.574 1.00
356_D 360_G 1.569 1.00
398_V 403_S 1.558 1.00
408_E 416_R 1.548 1.00
332_H 375_R 1.532 1.00
399_N 404_R 1.51 1.00
198_H 201_E 1.509 1.00
409_S 412_G 1.504 1.00
133_L 137_E 1.498 1.00
338_H 357_N 1.481 1.00
346_V 351_E 1.473 1.00
409_S 413_K 1.472 1.00
113_L 186_Q 1.463 1.00
225_Y 242_A 1.461 1.00
397_A 401_H 1.459 1.00
322_I 352_F 1.458 1.00
337_T 357_N 1.449 1.00
408_E 418_S 1.442 1.00
87_K 90_R 1.432 1.00
105_E 125_G 1.428 1.00
176_E 197_M 1.425 1.00
404_R 420_V 1.412 1.00
196_Q 199_Q 1.407 0.99
177_I 191_A 1.394 0.99
230_N 240_E 1.369 0.99
127_A 131_L 1.366 0.99
365_H 368_R 1.366 0.99
197_M 201_E 1.359 0.99
226_L 247_R 1.358 0.99
221_V 249_Q 1.351 0.99
90_R 94_G 1.349 0.99
314_N 317_Q 1.329 0.99
123_C 128_Q 1.326 0.99
317_Q 320_S 1.299 0.99
227_E 247_R 1.299 0.99
86_N 89_R 1.29 0.99
236_G 239_R 1.273 0.99
123_C 138_D 1.271 0.99
222_L 246_M 1.268 0.99
277_K 310_K 1.262 0.99
291_A 323_S 1.255 0.99
125_G 128_Q 1.251 0.99
128_Q 134_R 1.241 0.98
255_G 316_D 1.241 0.98
114_T 189_M 1.236 0.98
113_L 122_W 1.235 0.98
94_G 97_I 1.235 0.98
124_N 127_A 1.235 0.98
134_R 137_E 1.226 0.98
254_E 258_K 1.223 0.98
333_T 337_T 1.22 0.98
363_P 410_T 1.216 0.98
368_R 374_Y 1.211 0.98
110_A 127_A 1.21 0.98
350_A 423_E 1.207 0.98
369_L 407_I 1.205 0.98
174_H 198_H 1.203 0.98
142_N 145_N 1.191 0.98
286_V 315_E 1.188 0.98
305_I 343_W 1.186 0.98
370_T 407_I 1.186 0.98
100_F 103_G 1.175 0.98
321_A 419_F 1.173 0.98
320_S 397_A 1.161 0.97
229_M 239_R 1.157 0.97
281_P 305_I 1.156 0.97
173_R 193_D 1.152 0.97
148_R 151_E 1.15 0.97
275_N 312_S 1.144 0.97
229_M 243_L 1.134 0.97
84_L 87_K 1.128 0.97
403_S 421_I 1.123 0.97
280_V 352_F 1.12 0.96
292_Q 296_Q 1.112 0.96
284_L 322_I 1.11 0.96
222_L 250_T 1.109 0.96
225_Y 245_T 1.106 0.96
114_T 120_I 1.104 0.96
371_E 374_Y 1.099 0.96
226_L 250_T 1.091 0.96
70_G 73_E 1.088 0.96
284_L 341_V 1.087 0.96
361_I 366_I 1.085 0.96
406_N 420_V 1.085 0.96
119_G 142_N 1.082 0.96
232_Q 239_R 1.08 0.95
79_L 82_M 1.074 0.95
221_V 225_Y 1.072 0.95
327_Y 331_N 1.066 0.95
325_L 354_V 1.065 0.95
322_I 326_V 1.063 0.95
247_R 251_Q 1.062 0.95
287_V 326_V 1.058 0.95
169_L 172_G 1.054 0.95
295_S 330_V 1.052 0.95
240_E 244_H 1.048 0.94
398_V 405_L 1.046 0.94
368_R 371_E 1.046 0.94
279_D 310_K 1.045 0.94
359_P 384_T 1.045 0.94
294_L 297_K 1.044 0.94
377_D 382_R 1.044 0.94
287_V 319_R 1.038 0.94
94_G 98_K 1.033 0.94
361_I 367_P 1.031 0.94
291_A 326_V 1.021 0.93
226_L 230_N 1.019 0.93
291_A 330_V 1.015 0.93
98_K 102_S 1.014 0.93
369_L 417_F 1.01 0.93
226_L 243_L 1.007 0.93
113_L 121_F 1.004 0.93
317_Q 400_H 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i5sA20.98381000.31Contact Map0.853
4gczA20.78191000.408Contact Map0.787
3a0rA10.7611000.413Contact Map0.648
2c2aA10.55921000.553Contact Map0.776
3jz3A20.51041000.558Contact Map0.73
4e01A10.83761000.566Contact Map0.675
4ew8A20.60321000.566Contact Map0.844
2btzA10.71231000.568Contact Map0.622
3d36A20.5361000.572Contact Map0.832
2q8gA10.72391000.583Contact Map0.629

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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