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AK3 - Lysine-sensitive aspartokinase 3
UniProt: P08660 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10550
Length: 449 (447)
Sequences: 2146
Seq/Len: 4.80

AK3
Paralog alert: 0.39 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
405_E 446_N 3.792 1.00
181_T 208_L 3.595 1.00
135_V 178_L 3.477 1.00
188_E 192_R 3.237 1.00
435_D 438_Q 3.089 1.00
35_L 212_L 3.067 1.00
140_F 173_R 2.969 1.00
216_R 275_F 2.906 1.00
209_A 217_V 2.829 1.00
251_M 392_I 2.808 1.00
25_D 133_R 2.789 1.00
408_G 412_P 2.63 1.00
389_V 443_L 2.621 1.00
38_L 123_T 2.493 1.00
44_I 47_L 2.376 1.00
208_L 212_L 2.326 1.00
304_L 436_A 2.323 1.00
12_T 15_A 2.296 1.00
21_N 133_R 2.246 1.00
385_G 433_G 2.233 1.00
438_Q 441_Q 2.21 1.00
12_T 42_A 2.187 1.00
123_T 182_Q 2.179 1.00
224_P 281_D 2.148 1.00
148_T 194_T 2.146 1.00
150_D 188_E 2.14 1.00
28_L 32_N 2.071 1.00
127_V 137_A 2.063 1.00
114_L 124_L 2.01 1.00
309_T 355_T 1.997 1.00
242_E 290_C 1.987 1.00
23_S 126_F 1.985 1.00
275_F 288_L 1.981 1.00
218_D 275_F 1.965 1.00
396_L 401_G 1.939 1.00
28_L 133_R 1.916 1.00
131_R 136_Q 1.895 1.00
267_A 274_V 1.874 1.00
246_A 268_V 1.864 1.00
306_R 437_E 1.853 1.00
359_T 382_V 1.832 1.00
28_L 130_L 1.82 1.00
28_L 135_V 1.794 1.00
49_V 111_T 1.794 1.00
38_L 126_F 1.772 1.00
112_D 153_G 1.766 1.00
49_V 115_V 1.76 1.00
311_L 353_L 1.739 1.00
50_A 54_G 1.725 1.00
52_A 114_L 1.723 1.00
413_F 416_R 1.704 0.99
43_G 257_K 1.696 0.99
21_N 132_E 1.694 0.99
69_N 73_A 1.686 0.99
68_R 89_E 1.654 0.99
240_I 243_I 1.634 0.99
28_L 178_L 1.629 0.99
9_F 26_I 1.591 0.99
360_S 384_E 1.557 0.99
406_V 443_L 1.553 0.99
22_R 25_D 1.543 0.99
432_P 435_D 1.509 0.98
111_T 115_V 1.509 0.98
72_F 89_E 1.497 0.98
27_V 36_V 1.496 0.98
341_L 430_L 1.493 0.98
43_G 47_L 1.474 0.98
410_L 439_V 1.473 0.98
327_E 373_E 1.469 0.98
306_R 433_G 1.463 0.98
7_S 30_D 1.443 0.98
281_D 284_A 1.44 0.98
229_T 304_L 1.435 0.98
224_P 227_Y 1.43 0.98
409_V 446_N 1.423 0.97
107_S 131_R 1.416 0.97
391_L 427_L 1.414 0.97
129_I 133_R 1.413 0.97
120_L 193_T 1.404 0.97
62_E 66_A 1.403 0.97
210_E 272_I 1.403 0.97
236_A 445_S 1.397 0.97
168_L 172_P 1.395 0.97
15_A 42_A 1.391 0.97
221_T 276_V 1.379 0.97
138_Q 179_V 1.374 0.97
431_V 439_V 1.373 0.97
143_R 193_T 1.367 0.97
218_D 277_G 1.361 0.96
101_A 104_L 1.36 0.96
25_D 28_L 1.359 0.96
8_K 11_G 1.357 0.96
344_T 418_I 1.352 0.96
35_L 181_T 1.351 0.96
128_E 131_R 1.346 0.96
27_V 180_I 1.34 0.96
75_L 125_L 1.336 0.96
17_F 21_N 1.332 0.96
49_V 53_E 1.322 0.96
412_P 446_N 1.31 0.95
37_V 208_L 1.31 0.95
406_V 429_F 1.309 0.95
20_M 126_F 1.309 0.95
311_L 362_G 1.303 0.95
172_P 176_E 1.295 0.95
330_G 334_R 1.293 0.95
152_F 188_E 1.292 0.95
22_R 279_S 1.281 0.95
261_P 266_P 1.28 0.95
271_D 291_N 1.267 0.94
241_D 285_G 1.261 0.94
19_A 279_S 1.26 0.94
304_L 440_V 1.259 0.94
44_I 67_I 1.256 0.94
116_S 193_T 1.248 0.94
243_I 300_R 1.243 0.93
116_S 120_L 1.24 0.93
244_A 247_E 1.229 0.93
27_V 178_L 1.225 0.93
7_S 218_D 1.218 0.92
334_R 373_E 1.212 0.92
387_A 436_A 1.209 0.92
368_Q 372_M 1.206 0.92
322_R 325_L 1.206 0.92
217_V 267_A 1.202 0.92
65_D 69_N 1.198 0.92
148_T 186_G 1.193 0.91
389_V 431_V 1.193 0.91
401_G 424_S 1.19 0.91
385_G 434_E 1.181 0.91
12_T 43_G 1.181 0.91
12_T 221_T 1.177 0.91
52_A 111_T 1.17 0.90
123_T 141_D 1.164 0.90
402_V 427_L 1.158 0.90
136_Q 176_E 1.157 0.90
68_R 93_E 1.152 0.89
340_D 352_T 1.145 0.89
171_L 175_N 1.143 0.89
320_H 325_L 1.143 0.89
391_L 406_V 1.14 0.89
364_T 367_T 1.14 0.89
65_D 68_R 1.139 0.89
386_L 430_L 1.138 0.89
307_N 355_T 1.136 0.88
229_T 234_V 1.136 0.88
389_V 439_V 1.136 0.88
73_A 77_R 1.129 0.88
142_V 145_V 1.128 0.88
142_V 182_Q 1.126 0.88
117_H 121_M 1.123 0.88
355_T 433_G 1.12 0.88
87_E 124_L 1.114 0.87
42_A 46_N 1.114 0.87
329_F 342_I 1.111 0.87
233_V 440_V 1.111 0.87
29_S 282_P 1.109 0.87
233_V 304_L 1.107 0.87
30_D 218_D 1.106 0.87
154_R 336_N 1.103 0.86
312_T 350_A 1.102 0.86
228_T 444_H 1.101 0.86
158_D 161_A 1.1 0.86
147_R 191_G 1.097 0.86
414_N 418_I 1.095 0.86
405_E 409_V 1.095 0.86
224_P 278_S 1.093 0.86
167_A 171_L 1.091 0.86
383_E 386_L 1.08 0.85
363_D 367_T 1.08 0.85
403_G 407_F 1.079 0.85
318_M 323_G 1.079 0.85
24_A 133_R 1.079 0.85
337_I 353_L 1.078 0.85
143_R 187_S 1.076 0.85
340_D 388_L 1.076 0.85
305_R 308_Q 1.075 0.84
40_A 45_T 1.071 0.84
14_V 122_S 1.071 0.84
364_T 368_Q 1.065 0.84
9_F 13_S 1.064 0.84
332_L 370_L 1.062 0.83
27_V 130_L 1.061 0.83
355_T 384_E 1.06 0.83
31_A 178_L 1.059 0.83
130_L 135_V 1.059 0.83
326_A 333_A 1.058 0.83
325_L 349_V 1.056 0.83
13_S 279_S 1.055 0.83
329_F 339_V 1.055 0.83
213_H 270_S 1.053 0.83
42_A 257_K 1.053 0.83
206_A 217_V 1.053 0.83
41_S 74_I 1.05 0.83
82_N 86_E 1.045 0.82
409_V 442_K 1.044 0.82
342_I 403_G 1.041 0.82
89_E 93_E 1.038 0.82
62_E 89_E 1.038 0.82
62_E 65_D 1.035 0.81
138_Q 177_G 1.033 0.81
9_F 14_V 1.028 0.81
9_F 30_D 1.028 0.81
30_D 33_V 1.027 0.81
50_A 53_E 1.022 0.80
216_R 288_L 1.02 0.80
242_E 288_L 1.017 0.80
13_S 219_I 1.015 0.79
166_A 208_L 1.014 0.79
342_I 407_F 1.013 0.79
389_V 440_V 1.012 0.79
437_E 441_Q 1.011 0.79
68_R 72_F 1.005 0.79
337_I 365_L 1.004 0.78
75_L 88_I 1.003 0.78
345_S 350_A 1.003 0.78
88_I 125_L 1.001 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2j0wA111000.179Contact Map0.64
2cdqA20.98661000.248Contact Map0.687
3c1mA40.98441000.271Contact Map0.762
3tviA120.93991000.286Contact Map0.716
3l76A20.86641000.34Contact Map0.647
3ab4A80.86411000.342Contact Map0.819
1ybdA30.47441000.752Contact Map0.617
4a7wA20.47441000.753Contact Map0.664
2a1fA60.50781000.753Contact Map0.643
4jz8A40.59471000.755Contact Map0.568

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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