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AVTA - Valine--pyruvate aminotransferase
UniProt: P09053 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10107
Length: 417 (374)
Sequences: 16909
Seq/Len: 45.21

AVTA
Paralog alert: 0.94 [within 20: 0.22] - ratio of genomes with paralogs
Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
55_T 59_E 3.566 1.00
312_Q 395_P 3.51 1.00
311_Y 315_Q 3.19 1.00
198_D 202_L 3.09 1.00
88_R 94_D 3.052 1.00
103_T 109_A 2.738 1.00
48_D 52_T 2.676 1.00
331_L 344_W 2.644 1.00
316_E 399_E 2.584 1.00
400_A 404_I 2.58 1.00
362_R 407_E 2.573 1.00
358_R 361_A 2.525 1.00
82_L 294_K 2.46 1.00
400_A 403_K 2.439 1.00
262_A 267_I 2.393 1.00
78_E 290_C 2.328 1.00
202_L 206_A 2.205 1.00
351_T 354_Q 2.182 1.00
197_T 200_E 2.158 1.00
52_T 56_D 2.126 1.00
81_T 85_G 2.124 1.00
208_A 215_L 2.116 1.00
199_E 202_L 2.091 1.00
320_I 402_V 2.084 1.00
320_I 403_K 2.07 1.00
319_A 323_R 2.069 1.00
257_C 289_M 1.988 1.00
111_F 115_N 1.983 1.00
316_E 395_P 1.964 1.00
85_G 294_K 1.949 1.00
77_T 81_T 1.925 1.00
212_G 240_N 1.925 1.00
125_R 181_G 1.919 1.00
315_Q 319_A 1.903 1.00
81_T 97_P 1.885 1.00
172_E 203_K 1.856 1.00
182_M 216_V 1.832 1.00
84_A 97_P 1.831 1.00
220_A 246_S 1.829 1.00
318_I 322_R 1.827 1.00
216_V 244_C 1.823 1.00
318_I 334_K 1.821 1.00
35_L 401_G 1.813 1.00
394_E 397_K 1.788 1.00
113_L 242_V 1.786 1.00
203_K 206_A 1.772 1.00
366_M 387_M 1.759 1.00
106_S 244_C 1.748 1.00
358_R 408_E 1.729 1.00
322_R 332_I 1.727 1.00
320_I 323_R 1.717 1.00
168_H 200_E 1.694 1.00
260_I 270_I 1.68 1.00
56_D 291_E 1.674 1.00
82_L 85_G 1.67 1.00
170_D 173_H 1.661 1.00
317_T 341_L 1.656 1.00
51_Q 55_T 1.645 1.00
320_I 406_A 1.64 1.00
359_L 405_L 1.638 1.00
318_I 341_L 1.636 1.00
128_K 177_G 1.632 1.00
352_T 370_H 1.625 1.00
160_L 200_E 1.618 1.00
206_A 210_Q 1.612 1.00
316_E 320_I 1.607 1.00
76_K 287_A 1.607 1.00
134_A 152_S 1.601 1.00
171_F 207_L 1.588 1.00
78_E 294_K 1.585 1.00
362_R 404_I 1.581 1.00
403_K 407_E 1.574 1.00
87_L 261_I 1.566 1.00
206_A 209_N 1.561 1.00
208_A 213_I 1.56 1.00
171_F 203_K 1.556 1.00
98_Q 264_E 1.554 1.00
113_L 216_V 1.553 1.00
354_Q 358_R 1.535 1.00
53_L 291_E 1.523 1.00
320_I 399_E 1.518 1.00
406_A 410_E 1.513 1.00
56_D 60_S 1.509 1.00
30_P 363_G 1.507 1.00
282_G 285_G 1.504 1.00
320_I 324_Y 1.494 1.00
128_K 180_T 1.493 1.00
95_I 261_I 1.492 1.00
323_R 406_A 1.488 1.00
308_P 311_Y 1.486 1.00
83_L 259_I 1.486 1.00
85_G 89_E 1.472 1.00
342_W 369_G 1.462 1.00
84_A 100_I 1.461 1.00
207_L 211_H 1.458 1.00
99_N 264_E 1.458 1.00
83_L 102_L 1.455 1.00
356_Y 366_M 1.449 1.00
141_A 145_L 1.446 1.00
309_F 395_P 1.423 1.00
317_T 402_V 1.405 0.99
82_L 290_C 1.403 0.99
128_K 179_E 1.39 0.99
52_T 55_T 1.385 0.99
324_Y 403_K 1.384 0.99
74_Q 80_L 1.366 0.99
114_F 184_C 1.363 0.99
48_D 51_Q 1.362 0.99
395_P 399_E 1.349 0.99
128_K 151_V 1.347 0.99
154_R 173_H 1.34 0.99
318_I 332_I 1.334 0.99
247_L 289_M 1.333 0.99
351_T 384_H 1.331 0.99
296_N 300_R 1.331 0.99
80_L 84_A 1.326 0.99
207_L 213_I 1.324 0.99
74_Q 271_T 1.316 0.99
242_V 260_I 1.306 0.99
200_E 203_K 1.305 0.99
77_T 97_P 1.294 0.99
242_V 262_A 1.292 0.99
322_R 334_K 1.291 0.99
176_I 207_L 1.29 0.99
399_E 403_K 1.287 0.99
51_Q 59_E 1.282 0.99
354_Q 357_Q 1.281 0.99
96_E 264_E 1.271 0.99
309_F 312_Q 1.271 0.99
314_V 318_I 1.267 0.99
101_A 267_I 1.266 0.99
117_F 214_P 1.266 0.99
343_L 389_M 1.262 0.99
344_W 386_C 1.261 0.99
290_C 294_K 1.26 0.99
108_S 274_N 1.254 0.99
78_E 287_A 1.252 0.99
199_E 203_K 1.245 0.98
303_E 308_P 1.237 0.98
245_M 259_I 1.233 0.98
114_F 144_G 1.22 0.98
397_K 400_A 1.217 0.98
54_L 58_L 1.216 0.98
134_A 154_R 1.216 0.98
83_L 100_I 1.208 0.98
274_N 278_S 1.204 0.98
54_L 288_M 1.199 0.98
116_L 273_M 1.195 0.98
359_L 366_M 1.185 0.98
304_T 308_P 1.184 0.98
87_L 259_I 1.179 0.98
101_A 270_I 1.176 0.98
205_D 215_L 1.172 0.98
100_I 261_I 1.171 0.98
314_V 391_Y 1.169 0.97
362_R 411_R 1.167 0.97
364_V 405_L 1.167 0.97
317_T 398_I 1.166 0.97
114_F 118_A 1.161 0.97
99_N 238_N 1.16 0.97
319_A 399_E 1.159 0.97
269_A 272_N 1.159 0.97
291_E 294_K 1.156 0.97
355_L 387_M 1.15 0.97
177_G 180_T 1.15 0.97
291_E 295_R 1.148 0.97
303_E 307_K 1.142 0.97
79_L 102_L 1.14 0.97
315_Q 334_K 1.14 0.97
104_N 108_S 1.139 0.97
308_P 312_Q 1.137 0.97
128_K 149_L 1.134 0.97
209_N 239_P 1.126 0.97
268_T 272_N 1.118 0.96
52_T 59_E 1.112 0.96
205_D 241_I 1.11 0.96
53_L 57_M 1.106 0.96
85_G 88_R 1.094 0.96
53_L 56_D 1.094 0.96
324_Y 406_A 1.085 0.96
160_L 170_D 1.084 0.96
109_A 244_C 1.079 0.95
244_C 260_I 1.076 0.95
118_A 149_L 1.076 0.95
96_E 99_N 1.069 0.95
317_T 320_I 1.059 0.95
176_I 213_I 1.059 0.95
319_A 322_R 1.049 0.94
31_G 397_K 1.043 0.94
396_E 399_E 1.042 0.94
330_C 343_L 1.037 0.94
51_Q 58_L 1.035 0.94
84_A 96_E 1.032 0.94
86_M 90_K 1.032 0.94
35_L 398_I 1.027 0.94
309_F 313_R 1.026 0.94
160_L 163_G 1.024 0.93
89_E 299_L 1.023 0.93
314_V 335_P 1.018 0.93
117_F 182_M 1.017 0.93
257_C 281_P 1.016 0.93
353_K 370_H 1.016 0.93
358_R 362_R 1.011 0.93
67_L 287_A 1.01 0.93
106_S 246_S 1.007 0.93
77_T 80_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3if2A20.98081000.321Contact Map0.65
3g7qA10.97841000.323Contact Map0.658
4je5A30.94721000.341Contact Map0.728
1vp4A20.93051000.358Contact Map0.798
2r2nA40.92091000.367Contact Map0.706
3pplA20.91851000.368Contact Map0.595
3ez1A20.90651000.376Contact Map0.638
2zc0A40.91851000.377Contact Map0.782
3dydA20.90651000.378Contact Map0.775
3fvsA20.93051000.379Contact Map0.697

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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