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ARGT - Lysine-arginine-ornithine-binding periplasmic protein
UniProt: P09551 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10072
Length: 260 (234)
Sequences: 10326
Seq/Len: 44.13

ARGT
Paralog alert: 0.90 [within 20: 0.40] - ratio of genomes with paralogs
Cluster includes: ARGT ARTI ARTJ FLIY GLNH GLTI HISJ YHDW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
137_G 177_L 3.871 1.00
31_G 86_I 3.509 1.00
27_T 68_T 3.322 1.00
62_R 238_E 3.319 1.00
107_D 237_G 2.703 1.00
97_D 100_Q 2.466 1.00
162_Y 171_D 2.46 1.00
29_R 68_T 2.435 1.00
95_I 218_G 2.428 1.00
244_T 247_K 2.357 1.00
95_I 100_Q 2.296 1.00
27_T 66_K 2.265 1.00
229_T 233_N 2.242 1.00
246_D 250_K 2.203 1.00
80_S 86_I 2.187 1.00
29_R 70_V 2.154 1.00
103_I 220_G 2.127 1.00
145_E 161_A 2.108 1.00
60_C 67_C 2.101 1.00
237_G 241_Q 2.088 1.00
164_N 167_L 2.069 1.00
58_E 61_K 2.042 1.00
145_E 149_N 2.036 1.00
127_T 130_S 2.006 1.00
221_L 229_T 2.001 1.00
43_D 49_V 1.961 1.00
135_H 160_V 1.945 1.00
221_L 232_F 1.938 1.00
82_K 102_E 1.937 1.00
107_D 233_N 1.933 1.00
104_A 229_T 1.883 1.00
135_H 158_D 1.877 1.00
58_E 244_T 1.877 1.00
182_Q 187_A 1.809 1.00
54_D 251_K 1.779 1.00
62_R 235_A 1.754 1.00
222_R 225_D 1.748 1.00
58_E 62_R 1.725 1.00
126_P 130_S 1.722 1.00
58_E 239_L 1.709 1.00
62_R 242_D 1.703 1.00
90_I 219_V 1.687 1.00
226_A 230_A 1.656 1.00
43_D 47_D 1.644 1.00
54_D 252_Y 1.641 1.00
106_S 233_N 1.64 1.00
104_A 224_D 1.625 1.00
117_I 187_A 1.607 1.00
230_A 234_K 1.593 1.00
168_V 180_A 1.534 1.00
30_I 56_G 1.497 1.00
134_K 178_D 1.484 1.00
119_A 122_S 1.461 1.00
80_S 85_K 1.439 1.00
136_V 179_A 1.402 0.99
171_D 176_R 1.383 0.99
119_A 175_G 1.381 0.99
30_I 88_A 1.36 0.99
172_L 177_L 1.359 0.99
231_A 234_K 1.352 0.99
106_S 232_F 1.346 0.99
63_M 235_A 1.34 0.99
98_K 101_Q 1.338 0.99
140_Q 163_A 1.334 0.99
146_A 150_E 1.316 0.99
57_N 69_W 1.316 0.99
184_E 188_S 1.313 0.99
104_A 226_A 1.308 0.99
89_I 93_L 1.307 0.99
41_S 49_V 1.3 0.99
52_D 109_L 1.292 0.99
163_A 167_L 1.277 0.99
78_I 103_I 1.275 0.99
234_K 238_E 1.274 0.99
51_F 248_M 1.245 0.98
231_A 235_A 1.245 0.98
120_K 201_A 1.24 0.98
244_T 248_M 1.24 0.98
59_M 235_A 1.239 0.98
121_G 201_A 1.232 0.98
26_E 65_V 1.224 0.98
77_L 89_I 1.217 0.98
88_A 232_F 1.216 0.98
84_K 222_R 1.216 0.98
73_D 76_A 1.214 0.98
137_G 162_Y 1.213 0.98
47_D 57_N 1.2 0.98
238_E 242_D 1.199 0.98
120_K 199_D 1.198 0.98
135_H 178_D 1.195 0.98
171_D 177_L 1.189 0.98
129_D 132_K 1.188 0.98
115_R 202_F 1.185 0.98
139_L 142_S 1.185 0.98
172_L 180_A 1.185 0.98
116_L 179_A 1.181 0.98
30_I 67_C 1.18 0.98
51_F 249_A 1.178 0.98
72_S 80_S 1.169 0.97
42_K 71_A 1.16 0.97
235_A 238_E 1.157 0.97
235_A 239_L 1.155 0.97
88_A 221_L 1.153 0.97
118_A 203_A 1.147 0.97
51_F 253_F 1.127 0.97
53_I 57_N 1.123 0.97
93_L 220_G 1.122 0.97
104_A 223_K 1.118 0.96
113_D 184_E 1.115 0.96
162_Y 168_V 1.109 0.96
147_Y 151_T 1.104 0.96
137_G 168_V 1.099 0.96
54_D 57_N 1.096 0.96
240_R 245_Y 1.096 0.96
79_P 82_K 1.095 0.96
55_L 239_L 1.091 0.96
56_G 90_I 1.085 0.96
62_R 239_L 1.082 0.96
115_R 184_E 1.067 0.95
170_S 173_A 1.067 0.95
56_G 69_W 1.065 0.95
132_K 156_G 1.062 0.95
172_L 200_F 1.051 0.94
55_L 245_Y 1.044 0.94
149_N 161_A 1.039 0.94
57_N 61_K 1.031 0.94
114_S 144_Q 1.029 0.94
125_Q 130_S 1.027 0.94
39_F 110_Y 1.025 0.93
226_A 229_T 1.018 0.93
239_L 244_T 1.018 0.93
48_F 53_I 1.014 0.93
118_A 122_S 1.013 0.93
118_A 179_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ylnA10.95771000.26Contact Map0.823
3k4uA60.88851000.265Contact Map0.841
1lstA10.91541000.265Contact Map0.831
3hv1A20.95381000.269Contact Map0.797
3h7mA10.91000.273Contact Map0.804
2vhaA20.92691000.273Contact Map0.801
3tqlA10.86921000.278Contact Map0.789
1xt8A20.96151000.279Contact Map0.864
3kbrA10.91000.28Contact Map0.813
3vv5A20.95771000.281Contact Map0.881

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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