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MODC - Molybdenum import ATP-binding protein ModC
UniProt: P09833 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10152
Length: 352 (339)
Sequences: 8752
Seq/Len: 25.82

MODC
Paralog alert: 0.82 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
211_G 215_E 4.934 1.00
114_A 119_E 4.6 1.00
28_A 196_A 4.579 1.00
54_R 61_V 4.285 1.00
25_G 198_R 4.025 1.00
208_K 222_M 3.932 1.00
298_A 314_L 3.614 1.00
106_V 110_D 3.292 1.00
301_V 315_E 2.965 1.00
94_R 98_R 2.938 1.00
94_R 123_D 2.923 1.00
121_L 124_R 2.903 1.00
94_R 110_D 2.829 1.00
5_N 18_N 2.829 1.00
108_Q 146_A 2.793 1.00
5_N 16_T 2.791 1.00
94_R 109_F 2.737 1.00
113_V 122_L 2.736 1.00
200_M 207_V 2.685 1.00
58_N 148_E 2.666 1.00
173_R 177_E 2.661 1.00
212_A 215_E 2.611 1.00
27_T 200_M 2.604 1.00
60_R 148_E 2.569 1.00
57_L 62_L 2.562 1.00
297_R 340_W 2.556 1.00
299_K 340_W 2.551 1.00
112_L 144_L 2.5 1.00
43_A 55_I 2.473 1.00
94_R 106_V 2.396 1.00
44_I 183_L 2.332 1.00
77_R 148_E 2.325 1.00
200_M 210_F 2.308 1.00
203_E 208_K 2.25 1.00
98_R 109_F 2.185 1.00
56_V 61_V 2.169 1.00
22_P 25_G 2.149 1.00
223_N 272_R 2.136 1.00
336_K 339_L 2.127 1.00
7_S 16_T 2.078 1.00
107_D 111_K 2.074 1.00
152_L 182_M 2.067 1.00
95_G 102_S 2.067 1.00
117_G 166_E 2.059 1.00
7_S 52_K 2.04 1.00
297_R 342_Y 2.037 1.00
299_K 315_E 2.014 1.00
42_N 48_T 1.929 1.00
60_R 71_L 1.921 1.00
7_S 14_C 1.895 1.00
238_T 270_A 1.87 1.00
88_F 100_G 1.866 1.00
9_T 14_C 1.843 1.00
232_S 274_R 1.831 1.00
223_N 234_I 1.804 1.00
97_L 140_G 1.803 1.00
116_L 140_G 1.801 1.00
227_P 234_I 1.777 1.00
27_T 210_F 1.77 1.00
43_A 50_P 1.768 1.00
223_N 227_P 1.748 1.00
105_M 109_F 1.719 1.00
98_R 105_M 1.717 1.00
217_W 278_S 1.689 1.00
234_I 272_R 1.67 1.00
309_Q 324_R 1.666 1.00
8_Q 43_A 1.664 1.00
56_V 59_G 1.657 1.00
72_T 75_K 1.656 1.00
108_Q 111_K 1.637 1.00
201_V 225_W 1.631 1.00
92_K 95_G 1.631 1.00
110_D 122_L 1.628 1.00
62_L 71_L 1.621 1.00
61_V 69_I 1.617 1.00
100_G 145_T 1.611 1.00
111_K 114_A 1.56 1.00
27_T 198_R 1.548 1.00
17_I 40_L 1.541 1.00
111_K 146_A 1.541 1.00
8_Q 51_Q 1.519 1.00
8_Q 48_T 1.518 1.00
215_E 219_S 1.513 1.00
92_K 125_L 1.513 1.00
175_T 180_I 1.493 1.00
9_T 52_K 1.486 1.00
110_D 114_A 1.484 1.00
22_P 198_R 1.476 1.00
97_L 113_V 1.472 1.00
236_K 270_A 1.47 1.00
112_L 143_L 1.465 1.00
35_A 202_L 1.45 1.00
19_E 200_M 1.441 1.00
214_E 218_G 1.434 1.00
50_P 55_I 1.433 1.00
156_L 171_L 1.431 1.00
314_L 343_A 1.426 1.00
103_K 107_D 1.425 1.00
110_D 119_E 1.401 0.99
146_A 177_E 1.396 0.99
237_V 271_L 1.383 0.99
172_Q 195_L 1.38 0.99
104_S 107_D 1.379 0.99
175_T 182_M 1.374 0.99
303_S 312_V 1.372 0.99
79_G 145_T 1.333 0.99
156_L 184_Y 1.331 0.99
104_S 108_Q 1.324 0.99
300_V 312_V 1.309 0.99
26_I 175_T 1.308 0.99
29_I 200_M 1.294 0.99
23_A 58_N 1.272 0.99
315_E 318_G 1.272 0.99
281_S 344_Q 1.268 0.99
19_E 210_F 1.261 0.99
203_E 224_P 1.242 0.98
6_F 43_A 1.231 0.98
26_I 195_L 1.228 0.98
111_K 177_E 1.223 0.98
71_L 75_K 1.222 0.98
55_I 62_L 1.21 0.98
186_S 192_I 1.207 0.98
218_G 305_D 1.2 0.98
236_K 272_R 1.184 0.98
198_R 210_F 1.184 0.98
61_V 70_C 1.179 0.98
50_P 63_N 1.178 0.98
57_L 78_V 1.168 0.97
211_G 216_V 1.167 0.97
40_L 202_L 1.164 0.97
117_G 170_Y 1.149 0.97
6_F 50_P 1.144 0.97
85_A 158_S 1.141 0.97
95_G 98_R 1.141 0.97
5_N 52_K 1.133 0.97
275_I 280_V 1.131 0.97
97_L 109_F 1.13 0.97
79_G 182_M 1.123 0.97
78_V 149_L 1.114 0.96
298_A 341_L 1.109 0.96
97_L 112_L 1.106 0.96
240_L 252_A 1.103 0.96
280_V 345_I 1.102 0.96
283_V 342_Y 1.1 0.96
162_P 227_P 1.099 0.96
201_V 216_V 1.093 0.96
113_V 118_I 1.088 0.96
88_F 145_T 1.077 0.95
152_L 184_Y 1.077 0.95
238_T 252_A 1.077 0.95
314_L 323_A 1.073 0.95
311_E 324_R 1.067 0.95
172_Q 176_R 1.062 0.95
35_A 40_L 1.058 0.95
54_R 63_N 1.056 0.95
298_A 316_V 1.055 0.95
6_F 55_I 1.053 0.95
24_N 179_N 1.033 0.94
97_L 100_G 1.032 0.94
9_T 51_Q 1.028 0.94
209_A 225_W 1.003 0.93
61_V 64_D 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3d31A20.96881000.208Contact Map0.684
1oxxK10.95171000.224Contact Map0.705
1v43A10.95171000.226Contact Map0.838
2it1A20.93471000.227Contact Map0.851
3fvqA20.95171000.23Contact Map0.771
1g29120.96311000.23Contact Map0.856
3rlfA20.94891000.236Contact Map0.807
2yyzA10.95171000.239Contact Map0.774
1z47A20.93751000.258Contact Map0.833
3gd7A40.93181000.324Contact Map0.686

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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