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ALR1 - Alanine racemase, biosynthetic
UniProt: P0A6B4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10001
Length: 359 (356)
Sequences: 2170
Seq/Len: 6.10

ALR1
Paralog alert: 0.34 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: ALR1 ALR2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
13_L 234_V 4.223 1.00
158_S 191_I 3.663 1.00
268_G 310_L 3.209 1.00
241_L 268_G 3.073 1.00
252_P 257_G 2.931 1.00
63_A 95_F 2.929 1.00
294_E 333_R 2.909 1.00
287_P 294_E 2.879 1.00
194_S 213_I 2.767 1.00
246_E 266_R 2.756 1.00
64_L 93_Q 2.678 1.00
267_L 298_V 2.587 1.00
258_T 300_R 2.541 1.00
248_K 264_D 2.536 1.00
20_L 213_I 2.518 1.00
238_T 321_P 2.515 1.00
349_L 353_V 2.502 1.00
252_P 260_V 2.45 1.00
323_I 328_G 2.424 1.00
239_S 270_V 2.409 1.00
237_L 272_M 2.375 1.00
295_V 313_Q 2.349 1.00
90_I 97_T 2.325 1.00
290_V 308_V 2.306 1.00
259_W 265_T 2.277 1.00
263_R 312_P 2.274 1.00
254_G 302_A 2.273 1.00
179_N 205_F 2.259 1.00
124_D 128_H 2.219 1.00
247_H 261_S 2.211 1.00
128_H 251_E 2.202 1.00
32_V 56_G 2.182 1.00
15_H 232_Q 2.172 1.00
248_K 261_S 2.147 1.00
9_N 12_A 2.13 1.00
28_K 53_D 2.071 1.00
278_Y 324_L 2.033 1.00
288_V 308_V 2.024 1.00
36_N 351_S 1.985 1.00
7_V 238_T 1.982 1.00
249_A 264_D 1.957 1.00
241_L 316_D 1.928 1.00
217_V 346_I 1.904 1.00
163_A 195_G 1.9 1.00
332_E 342_A 1.893 1.00
173_K 177_I 1.88 1.00
246_E 264_D 1.859 1.00
118_T 152_Q 1.856 1.00
162_R 257_G 1.833 1.00
43_L 69_G 1.809 1.00
331_V 346_I 1.805 1.00
175_L 203_S 1.796 1.00
248_K 251_E 1.722 1.00
17_L 214_L 1.721 1.00
30_V 207_W 1.718 1.00
132_V 140_F 1.712 1.00
270_V 322_V 1.711 1.00
217_V 342_A 1.705 1.00
10_R 357_Y 1.688 1.00
244_V 310_L 1.683 1.00
304_D 352_R 1.66 1.00
19_R 22_E 1.654 1.00
279_P 348_R 1.641 1.00
176_A 180_T 1.634 1.00
265_T 311_G 1.63 1.00
120_W 190_S 1.629 1.00
289_L 323_I 1.628 1.00
291_N 320_D 1.608 1.00
317_K 320_D 1.585 0.99
289_L 329_L 1.584 0.99
302_A 307_C 1.579 0.99
46_A 66_L 1.57 0.99
55_F 73_K 1.563 0.99
5_T 238_T 1.543 0.99
13_L 45_T 1.516 0.99
290_V 295_V 1.516 0.99
40_H 235_M 1.514 0.99
42_L 65_R 1.513 0.99
175_L 205_F 1.507 0.99
30_V 56_G 1.495 0.99
269_V 307_C 1.487 0.99
14_R 48_T 1.484 0.99
98_A 157_V 1.453 0.99
6_V 353_V 1.434 0.99
96_H 154_V 1.419 0.98
265_T 309_D 1.405 0.98
241_L 244_V 1.403 0.98
289_L 294_E 1.403 0.98
241_L 310_L 1.402 0.98
182_C 189_R 1.4 0.98
173_K 176_A 1.398 0.98
170_A 257_G 1.392 0.98
270_V 306_I 1.391 0.98
109_E 147_C 1.387 0.98
15_H 19_R 1.383 0.98
263_R 311_G 1.382 0.98
162_R 171_T 1.374 0.98
49_L 214_L 1.35 0.98
235_M 325_W 1.349 0.98
4_A 239_S 1.345 0.98
162_R 165_E 1.333 0.97
278_Y 297_I 1.322 0.97
310_L 316_D 1.322 0.97
49_L 55_F 1.319 0.97
123_L 181_F 1.31 0.97
197_I 210_P 1.306 0.97
251_E 261_S 1.299 0.97
237_L 353_V 1.294 0.97
31_A 214_L 1.287 0.97
252_P 261_S 1.284 0.97
68_A 93_Q 1.267 0.96
35_A 275_G 1.267 0.96
189_R 206_D 1.259 0.96
261_S 265_T 1.253 0.96
258_T 284_S 1.244 0.96
241_L 290_V 1.232 0.95
12_A 232_Q 1.232 0.95
192_A 203_S 1.229 0.95
262_E 265_T 1.213 0.95
122_K 130_L 1.203 0.95
265_T 298_V 1.199 0.94
24_A 27_S 1.19 0.94
301_V 306_I 1.188 0.94
280_R 341_S 1.181 0.94
4_A 272_M 1.18 0.94
17_L 29_M 1.17 0.93
6_V 237_L 1.16 0.93
278_Y 334_I 1.157 0.93
17_L 49_L 1.154 0.93
6_V 235_M 1.151 0.93
192_A 204_H 1.151 0.93
44_E 357_Y 1.15 0.93
43_L 65_R 1.141 0.92
124_D 245_R 1.127 0.92
286_T 297_I 1.124 0.92
94_H 115_E 1.121 0.91
272_M 324_L 1.109 0.91
253_V 267_L 1.108 0.91
335_A 340_V 1.104 0.91
15_H 230_G 1.101 0.90
160_F 196_G 1.1 0.90
50_P 73_K 1.098 0.90
325_W 331_V 1.094 0.90
239_S 306_I 1.091 0.90
20_L 210_P 1.085 0.90
33_V 46_A 1.084 0.90
21_R 53_D 1.081 0.89
310_L 313_Q 1.073 0.89
24_A 208_V 1.071 0.89
19_R 23_L 1.07 0.89
175_L 179_N 1.066 0.88
254_G 307_C 1.064 0.88
212_I 343_Y 1.063 0.88
44_E 47_R 1.057 0.88
240_S 321_P 1.056 0.88
130_L 305_M 1.055 0.88
295_V 311_G 1.052 0.88
60_L 63_A 1.045 0.87
289_L 328_G 1.039 0.87
253_V 265_T 1.037 0.87
170_A 252_P 1.037 0.87
66_L 71_I 1.032 0.86
10_R 48_T 1.03 0.86
235_M 349_L 1.022 0.86
213_I 231_C 1.02 0.85
192_A 196_G 1.019 0.85
9_N 358_V 1.017 0.85
43_L 71_I 1.015 0.85
250_G 261_S 1.005 0.84
130_L 269_V 1.004 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1bd0A20.98051000.231Contact Map0.862
3e5pA30.98051000.238Contact Map0.848
2rjgA40.99721000.244Contact Map0.829
3hurA10.97771000.244Contact Map0.658
1rcqA10.98891000.25Contact Map0.798
2vd8A20.98051000.253Contact Map0.901
3mubA20.97491000.259Contact Map0.852
3co8A20.98051000.261Contact Map0.796
3kw3A20.98051000.261Contact Map0.798
4a3qA20.98051000.262Contact Map0.837

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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