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ARGB - Acetylglutamate kinase
UniProt: P0A6C8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10064
Length: 258 (255)
Sequences: 1944
Seq/Len: 7.62

ARGB
Paralog alert: 0.46 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
39_V 172_L 3.459 1.00
151_T 155_Q 3.09 1.00
69_P 72_Q 3.012 1.00
202_E 226_R 2.835 1.00
198_A 222_L 2.743 1.00
110_V 164_A 2.575 1.00
110_V 128_G 2.533 1.00
70_A 121_H 2.533 1.00
183_S 236_S 2.506 1.00
113_T 126_Q 2.505 1.00
145_V 168_L 2.42 1.00
113_T 124_L 2.321 1.00
203_Q 207_Q 2.087 1.00
57_L 71_D 2.038 1.00
114_Q 118_E 2.03 1.00
92_A 144_V 2.006 1.00
197_T 200_K 2 1.00
149_G 159_V 1.977 1.00
231_P 255_R 1.943 1.00
5_L 35_Q 1.895 1.00
200_K 203_Q 1.888 1.00
245_A 251_P 1.838 1.00
130_P 134_N 1.789 1.00
73_I 76_I 1.788 1.00
221_A 232_V 1.745 1.00
97_I 142_L 1.74 1.00
186_L 192_R 1.729 1.00
201_A 222_L 1.728 1.00
175_D 230_R 1.667 1.00
19_A 23_L 1.66 1.00
20_L 24_F 1.647 1.00
50_E 53_K 1.646 1.00
183_S 186_L 1.645 1.00
187_D 191_Q 1.641 1.00
134_N 138_E 1.633 1.00
77_T 105_G 1.627 1.00
53_K 58_P 1.615 1.00
188_G 191_Q 1.599 1.00
111_K 127_P 1.582 1.00
20_L 23_L 1.556 1.00
114_Q 157_M 1.544 1.00
55_L 75_I 1.533 1.00
170_A 225_A 1.493 0.99
170_A 227_T 1.477 0.99
66_R 158_N 1.447 0.99
218_V 222_L 1.436 0.99
225_A 232_V 1.433 0.99
135_S 139_N 1.424 0.99
51_L 55_L 1.422 0.99
196_M 201_A 1.416 0.99
52_M 59_V 1.411 0.99
7_I 27_L 1.411 0.99
210_I 218_V 1.408 0.99
112_V 149_G 1.408 0.99
202_E 206_E 1.407 0.99
132_L 135_S 1.403 0.99
51_L 79_A 1.401 0.99
205_I 219_N 1.398 0.99
151_T 157_M 1.386 0.99
185_I 218_V 1.376 0.99
188_G 209_I 1.374 0.99
28_V 97_I 1.374 0.99
36_R 137_L 1.363 0.99
85_N 101_G 1.35 0.99
81_A 103_F 1.334 0.98
51_L 78_G 1.301 0.98
100_V 136_L 1.301 0.98
111_K 152_D 1.288 0.98
25_S 95_H 1.287 0.98
89_L 99_A 1.279 0.98
65_L 163_Q 1.274 0.98
44_G 80_L 1.272 0.98
136_L 141_Y 1.266 0.98
6_I 174_A 1.247 0.97
54_G 74_D 1.239 0.97
85_N 89_L 1.213 0.97
110_V 168_L 1.21 0.97
133_I 168_L 1.21 0.97
195_E 255_R 1.203 0.96
49_D 59_V 1.197 0.96
198_A 226_R 1.193 0.96
248_N 251_P 1.187 0.96
52_M 57_L 1.178 0.96
111_K 129_S 1.161 0.95
92_A 97_I 1.16 0.95
86_K 106_D 1.15 0.95
20_L 25_S 1.149 0.95
245_A 248_N 1.148 0.95
50_E 54_G 1.146 0.95
166_T 220_A 1.145 0.95
184_G 192_R 1.144 0.95
76_I 148_I 1.133 0.95
29_N 33_S 1.131 0.95
179_L 235_A 1.129 0.94
62_K 67_V 1.129 0.94
48_V 76_I 1.124 0.94
149_G 164_A 1.093 0.93
10_G 42_H 1.088 0.93
202_E 219_N 1.084 0.93
9_L 14_L 1.076 0.92
202_E 222_L 1.073 0.92
59_V 72_Q 1.072 0.92
198_A 225_A 1.067 0.92
21_E 91_W 1.061 0.92
71_D 74_D 1.06 0.92
220_A 232_V 1.054 0.91
193_I 204_L 1.05 0.91
130_P 171_T 1.049 0.91
82_G 101_G 1.048 0.91
77_T 87_T 1.043 0.91
219_N 223_D 1.036 0.90
121_H 155_Q 1.034 0.90
45_G 213_G 1.033 0.90
70_A 155_Q 1.031 0.90
159_V 164_A 1.03 0.90
105_G 156_L 1.029 0.90
247_F 251_P 1.021 0.90
112_V 157_M 1.017 0.89
55_L 78_G 1.016 0.89
133_I 145_V 1.016 0.89
109_S 129_S 1.009 0.89
10_G 213_G 1.009 0.89
180_S 214_M 1.003 0.88
49_D 52_M 1.002 0.88
49_D 61_K 1 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gs5A10.99611000.239Contact Map0.669
2bufA120.99611000.248Contact Map0.852
2ap9A60.98841000.253Contact Map0.695
2v5hA60.99611000.259Contact Map0.757
2rd5A20.99611000.259Contact Map0.774
2btyA30.99221000.264Contact Map0.813
3l86A10.9381000.29Contact Map0.644
3s6kA10.9691000.301Contact Map0.572
3s6gA40.9691000.303Contact Map0.662
3zzhA40.96121000.315Contact Map0.758

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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