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ARGR - Arginine repressor
UniProt: P0A6D0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10070
Length: 156 (146)
Sequences: 842
Seq/Len: 5.77

ARGR
Paralog alert: 0.39 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
21_E 32_A 3.396 1.00
90_D 136_A 3.04 1.00
93_D 138_G 2.54 1.00
23_F 32_A 2.423 1.00
13_A 36_Q 2.354 1.00
13_A 38_F 2.192 1.00
112_L 148_I 2.116 1.00
17_L 32_A 1.848 1.00
13_A 16_A 1.824 1.00
14_F 23_F 1.772 1.00
32_A 35_E 1.698 1.00
50_L 55_A 1.663 1.00
137_N 140_T 1.595 0.99
135_P 141_V 1.589 0.99
135_P 144_L 1.576 0.99
10_L 49_M 1.543 0.99
113_D 127_G 1.496 0.99
100_T 127_G 1.493 0.99
105_A 129_D 1.472 0.99
113_D 124_T 1.441 0.98
92_N 122_L 1.438 0.98
30_V 46_V 1.424 0.98
25_S 50_L 1.407 0.98
100_T 105_A 1.371 0.98
22_K 66_V 1.371 0.98
7_Q 10_L 1.345 0.97
23_F 29_I 1.342 0.97
15_K 69_L 1.338 0.97
102_P 129_D 1.324 0.97
7_Q 11_V 1.305 0.97
51_T 65_M 1.303 0.97
113_D 123_G 1.3 0.97
58_T 68_C 1.288 0.96
120_G 147_A 1.283 0.96
110_R 129_D 1.277 0.96
142_K 146_E 1.272 0.96
113_D 130_T 1.266 0.96
41_I 46_V 1.254 0.96
27_G 57_R 1.251 0.95
95_V 134_T 1.249 0.95
140_T 143_D 1.236 0.95
127_G 130_T 1.22 0.95
126_A 131_I 1.22 0.95
46_V 104_A 1.219 0.95
102_P 128_D 1.202 0.94
7_Q 52_K 1.201 0.94
31_A 34_Q 1.193 0.94
105_A 113_D 1.169 0.93
30_V 41_I 1.159 0.92
96_V 145_Y 1.159 0.92
89_I 98_I 1.146 0.92
112_L 121_I 1.141 0.92
109_A 126_A 1.141 0.92
86_V 98_I 1.138 0.91
141_V 145_Y 1.136 0.91
25_S 55_A 1.129 0.91
92_N 141_V 1.125 0.91
124_T 127_G 1.112 0.90
118_A 121_I 1.112 0.90
102_P 110_R 1.109 0.90
147_A 150_E 1.103 0.90
103_G 128_D 1.097 0.89
97_V 127_G 1.087 0.89
122_L 127_G 1.085 0.89
16_A 20_E 1.084 0.89
31_A 119_E 1.074 0.88
113_D 129_D 1.072 0.88
25_S 28_E 1.057 0.87
92_N 137_N 1.044 0.86
17_L 21_E 1.042 0.86
11_V 53_F 1.037 0.85
26_Q 43_Q 1.032 0.85
138_G 141_V 1.031 0.85
96_V 135_P 1.03 0.85
31_A 35_E 1.026 0.85
100_T 113_D 1.022 0.84
54_G 59_R 1.022 0.84
11_V 52_K 1.018 0.84
45_K 49_M 1.016 0.84
109_A 113_D 1.014 0.84
92_N 135_P 1.011 0.83
32_A 36_Q 1.007 0.83
42_N 49_M 1 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3v4gA10.98721000.044Contact Map0.473
3lapA60.96151000.087Contact Map0.653
1b4aA60.93591000.191Contact Map0.755
2p5mA30.532199.90.55Contact Map0.663
2zfzA60.506499.90.554Contact Map0.609
1xxaA60.493699.90.56Contact Map0.593
1b4bA30.455199.90.56Contact Map0.666
2p5kA10.4103990.753Contact Map0.818
2fu4A20.442396.50.861Contact Map0.528
4l5jA40.910396.30.864Contact Map0.363

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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