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AROA - 3-phosphoshikimate 1-carboxyvinyltransferase
UniProt: P0A6D3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10073
Length: 427 (425)
Sequences: 3786
Seq/Len: 8.91

AROA
Paralog alert: 0.88 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: AROA MURA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
358_E 369_T 3.827 1.00
15_T 263_T 3.79 1.00
415_D 418_E 3.424 1.00
259_T 295_S 3.403 1.00
42_T 236_T 3.348 1.00
7_Q 426_A 3.314 1.00
208_M 213_V 3.183 1.00
186_D 226_K 3.165 1.00
36_H 230_S 3.148 1.00
261_K 295_S 3.08 1.00
214_E 226_K 2.998 1.00
255_I 393_L 2.964 1.00
38_K 76_I 2.829 1.00
17_N 263_T 2.823 1.00
42_T 238_L 2.765 1.00
413_F 419_Q 2.639 1.00
254_A 285_A 2.601 1.00
328_T 369_T 2.488 1.00
55_N 58_T 2.453 1.00
116_T 122_K 2.428 1.00
351_E 354_K 2.4 1.00
46_D 51_R 2.4 1.00
163_D 190_R 2.371 1.00
161_N 190_R 2.36 1.00
132_A 176_L 2.358 1.00
300_E 326_K 2.312 1.00
380_A 404_L 2.301 1.00
260_V 423_I 2.273 1.00
156_G 184_P 2.272 1.00
169_S 172_F 2.269 1.00
65_T 74_E 2.22 1.00
10_A 426_A 2.219 1.00
395_A 401_V 2.216 1.00
40_V 236_T 2.19 1.00
251_A 321_A 2.176 1.00
373_K 399_T 2.143 1.00
378_E 402_T 2.134 1.00
286_T 297_T 2.124 1.00
161_N 188_V 2.06 1.00
259_T 297_T 2.043 1.00
25_S 44_L 2 1.00
378_E 404_L 1.98 1.00
290_G 293_Y 1.979 1.00
177_L 205_L 1.971 1.00
328_T 367_R 1.969 1.00
302_N 326_K 1.874 1.00
38_K 74_E 1.872 1.00
362_G 365_Y 1.842 1.00
30_L 53_M 1.812 1.00
42_T 72_R 1.802 1.00
40_V 74_E 1.798 1.00
40_V 72_R 1.78 1.00
13_D 259_T 1.78 1.00
305_D 332_R 1.773 1.00
351_E 391_F 1.756 1.00
58_T 63_S 1.751 1.00
104_A 175_A 1.745 1.00
303_A 329_T 1.725 1.00
16_I 423_I 1.711 1.00
330_T 367_R 1.707 1.00
360_E 367_R 1.701 1.00
218_Q 223_F 1.694 1.00
209_K 218_Q 1.68 1.00
139_K 154_Q 1.673 1.00
261_K 290_G 1.66 1.00
320_T 390_C 1.639 1.00
261_K 293_Y 1.633 1.00
32_A 39_T 1.618 1.00
278_D 281_E 1.61 1.00
213_V 231_Y 1.609 1.00
324_F 397_S 1.6 1.00
58_T 64_Y 1.568 1.00
159_G 183_A 1.563 1.00
28_A 207_L 1.562 1.00
189_I 195_L 1.557 1.00
186_D 224_V 1.555 1.00
209_K 214_E 1.547 1.00
63_S 76_I 1.539 1.00
56_A 90_L 1.526 1.00
41_L 239_V 1.518 1.00
246_A 265_I 1.517 1.00
352_L 357_A 1.513 1.00
127_G 131_D 1.509 1.00
158_T 184_P 1.508 1.00
62_V 75_I 1.506 1.00
164_V 176_L 1.498 1.00
250_L 277_A 1.494 1.00
134_R 139_K 1.487 1.00
303_A 328_T 1.486 1.00
392_S 416_Y 1.485 1.00
131_D 135_L 1.472 1.00
349_A 359_V 1.472 1.00
37_G 234_P 1.461 1.00
338_R 343_D 1.46 1.00
288_C 295_S 1.45 0.99
327_G 370_P 1.448 0.99
96_G 100_R 1.446 0.99
322_A 329_T 1.445 0.99
360_E 369_T 1.443 0.99
35_A 39_T 1.433 0.99
355_V 401_V 1.432 0.99
247_S 314_A 1.416 0.99
95_A 98_A 1.41 0.99
188_V 224_V 1.405 0.99
250_L 280_L 1.403 0.99
240_E 269_S 1.398 0.99
122_K 144_E 1.396 0.99
355_V 377_A 1.392 0.99
184_P 229_Q 1.392 0.99
379_I 391_F 1.391 0.99
28_A 239_V 1.389 0.99
25_S 50_V 1.386 0.99
351_E 382_Y 1.371 0.99
46_D 66_L 1.37 0.99
15_T 261_K 1.366 0.99
288_C 297_T 1.363 0.99
141_T 152_R 1.344 0.99
251_A 276_F 1.343 0.99
190_R 222_Q 1.339 0.99
211_F 235_G 1.332 0.99
5_T 402_T 1.324 0.99
250_L 262_V 1.316 0.99
347_A 382_Y 1.297 0.99
7_Q 400_P 1.281 0.98
216_E 226_K 1.272 0.98
209_K 215_I 1.27 0.98
177_L 225_V 1.268 0.98
355_V 394_V 1.262 0.98
131_D 134_R 1.261 0.98
395_A 403_I 1.259 0.98
29_L 57_L 1.257 0.98
54_L 73_C 1.256 0.98
346_F 350_T 1.251 0.98
203_I 237_Y 1.248 0.98
29_L 54_L 1.246 0.98
28_A 41_L 1.246 0.98
252_A 396_L 1.244 0.98
18_L 262_V 1.24 0.98
357_A 374_L 1.231 0.98
323_L 357_A 1.228 0.98
322_A 331_L 1.227 0.98
27_R 30_L 1.224 0.98
359_V 366_I 1.224 0.98
120_R 123_E 1.22 0.98
44_L 50_V 1.211 0.98
54_L 64_Y 1.209 0.98
320_T 394_V 1.208 0.98
388_A 409_T 1.207 0.97
207_L 235_G 1.206 0.97
99_M 149_P 1.192 0.97
319_A 331_L 1.19 0.97
346_F 361_E 1.189 0.97
26_N 53_M 1.183 0.97
418_E 421_A 1.179 0.97
305_D 330_T 1.178 0.97
250_L 253_A 1.174 0.97
171_Q 174_T 1.171 0.97
283_M 325_A 1.166 0.97
62_V 77_G 1.157 0.97
252_A 393_L 1.155 0.96
112_D 150_P 1.154 0.96
349_A 366_I 1.154 0.96
237_Y 240_E 1.15 0.96
345_L 366_I 1.15 0.96
281_E 289_W 1.146 0.96
7_Q 10_A 1.142 0.96
183_A 187_T 1.138 0.96
283_M 304_I 1.135 0.96
281_E 286_T 1.131 0.96
251_A 314_A 1.126 0.96
210_T 235_G 1.118 0.96
303_A 325_A 1.113 0.95
174_T 204_T 1.11 0.95
37_G 77_G 1.108 0.95
266_G 269_S 1.104 0.95
130_V 134_R 1.099 0.95
303_A 326_K 1.099 0.95
249_F 413_F 1.096 0.95
200_Y 243_A 1.096 0.95
209_K 216_E 1.095 0.95
181_P 213_V 1.088 0.95
39_T 207_L 1.087 0.95
324_F 371_P 1.082 0.94
11_R 258_G 1.076 0.94
388_A 408_C 1.068 0.94
362_G 367_R 1.067 0.94
280_L 321_A 1.063 0.94
5_T 400_P 1.061 0.94
35_A 234_P 1.058 0.94
379_I 401_V 1.055 0.93
280_L 285_A 1.054 0.93
52_H 55_N 1.053 0.93
375_N 399_T 1.052 0.93
255_I 397_S 1.046 0.93
55_N 59_A 1.042 0.93
247_S 317_T 1.041 0.93
106_L 138_A 1.037 0.93
119_P 385_H 1.034 0.92
136_G 160_G 1.034 0.92
138_A 157_F 1.033 0.92
398_D 401_V 1.033 0.92
102_L 133_L 1.022 0.92
329_T 368_I 1.022 0.92
343_D 346_F 1.019 0.92
130_V 142_Y 1.018 0.92
216_E 224_V 1.016 0.92
349_A 361_E 1.016 0.92
21_S 25_S 1.014 0.92
420_L 425_Q 1.012 0.91
279_V 318_I 1.011 0.91
392_S 409_T 1.008 0.91
419_Q 422_R 1.001 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rmtA40.96961000.069Contact Map0.789
2pqcA10.96961000.095Contact Map0.753
3nvsA10.99531000.114Contact Map0.757
3slhA40.96491000.121Contact Map0.788
1rf6A40.96251000.139Contact Map0.761
2o0bA10.96721000.149Contact Map0.727
3zh4A10.94611000.201Contact Map0.791
4fqdA20.95781000.204Contact Map0.707
3r38A10.94381000.23Contact Map0.805
1ejdA20.94611000.25Contact Map0.78

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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