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AROK - Shikimate kinase 1
UniProt: P0A6D7 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10081
Length: 173 (168)
Sequences: 2166
Seq/Len: 12.89

AROK
Paralog alert: 0.26 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: AROK AROL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
42_R 69_E 3.257 1.00
38_E 41_K 2.976 1.00
45_A 53_L 2.621 1.00
21_G 32_F 2.612 1.00
157_Q 165_Q 2.352 1.00
64_E 87_S 2.351 1.00
104_E 153_R 2.228 1.00
45_A 54_E 2.207 1.00
135_A 139_E 2.171 1.00
141_N 145_E 2.024 1.00
91_R 146_E 1.994 1.00
51_F 56_E 1.986 1.00
8_F 98_G 1.946 1.00
61_D 87_S 1.941 1.00
104_E 151_T 1.911 1.00
43_T 50_V 1.778 1.00
64_E 89_E 1.728 1.00
109_K 112_A 1.66 1.00
64_E 90_T 1.628 1.00
35_S 84_S 1.623 1.00
131_E 135_A 1.6 1.00
54_E 58_G 1.578 1.00
95_S 149_D 1.578 1.00
35_S 70_L 1.551 1.00
43_T 58_G 1.545 1.00
58_G 62_R 1.539 1.00
49_W 53_L 1.497 1.00
35_S 67_I 1.496 1.00
159_A 163_A 1.467 1.00
13_M 122_L 1.457 1.00
61_D 65_K 1.453 1.00
10_V 147_I 1.452 1.00
106_T 155_D 1.444 1.00
9_L 24_L 1.442 1.00
86_K 143_L 1.434 1.00
105_T 154_T 1.433 1.00
102_Y 141_N 1.419 1.00
134_E 138_N 1.41 1.00
58_G 61_D 1.402 0.99
88_R 92_N 1.401 0.99
33_Y 76_I 1.39 0.99
86_K 139_E 1.359 0.99
35_S 66_V 1.348 0.99
38_E 66_V 1.323 0.99
25_A 32_F 1.317 0.99
37_Q 40_E 1.308 0.99
27_Q 163_A 1.305 0.99
105_T 110_Q 1.297 0.99
85_V 143_L 1.294 0.99
32_F 79_A 1.293 0.99
162_V 165_Q 1.285 0.99
43_T 62_R 1.27 0.99
152_I 166_I 1.269 0.99
13_M 51_F 1.26 0.99
23_Q 159_A 1.259 0.99
27_Q 164_N 1.252 0.99
158_S 161_V 1.238 0.98
108_E 130_R 1.232 0.98
101_V 150_V 1.224 0.98
50_V 58_G 1.215 0.98
137_A 141_N 1.213 0.98
54_E 62_R 1.209 0.98
30_M 75_G 1.192 0.98
49_W 52_D 1.189 0.98
64_E 67_I 1.187 0.98
67_I 84_S 1.166 0.97
40_E 46_D 1.162 0.97
102_Y 145_E 1.162 0.97
48_G 119_K 1.158 0.97
12_P 110_Q 1.157 0.97
94_L 100_V 1.146 0.97
67_I 94_L 1.138 0.97
8_F 78_L 1.138 0.97
150_V 169_M 1.136 0.97
20_I 163_A 1.132 0.97
8_F 94_L 1.103 0.96
20_I 162_V 1.1 0.96
45_A 50_V 1.095 0.96
107_I 137_A 1.094 0.96
12_P 133_L 1.089 0.96
51_F 122_L 1.085 0.96
163_A 166_I 1.065 0.95
91_R 147_I 1.065 0.95
13_M 56_E 1.059 0.95
92_N 96_A 1.052 0.95
148_A 151_T 1.041 0.94
157_Q 161_V 1.034 0.94
128_P 131_E 1.022 0.93
101_V 152_I 1.014 0.93
24_L 166_I 1.013 0.93
46_D 49_W 1.011 0.93
35_S 78_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nwjA20.98841000.409Contact Map0.686
1e6cA20.97111000.437Contact Map0.685
1viaA20.95381000.437Contact Map0.809
3trfA20.99421000.443Contact Map0.707
2pt5A40.9481000.444Contact Map0.802
3vaaA30.99421000.476Contact Map0.688
1zuhA10.93641000.478Contact Map0.788
1kagA211000.479Contact Map0.776
2iyvA10.97691000.484Contact Map0.704
2axnA10.982799.90.515Contact Map0.199

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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