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AROL - Shikimate kinase 2
UniProt: P0A6E1 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10082
Length: 174 (168)
Sequences: 2149
Seq/Len: 12.79

AROL
Paralog alert: 0.26 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: AROK AROL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
40_Q 67_A 3.269 1.00
36_W 39_S 3.104 1.00
19_G 30_F 2.694 1.00
43_M 51_R 2.592 1.00
62_T 84_T 2.374 1.00
101_C 152_D 2.262 1.00
134_E 138_E 2.231 1.00
43_M 52_E 2.17 1.00
88_R 145_E 2.072 1.00
140_D 144_R 2.03 1.00
6_F 95_G 1.972 1.00
59_A 84_T 1.96 1.00
101_C 150_I 1.953 1.00
49_V 54_W 1.942 1.00
62_T 86_F 1.769 1.00
41_L 48_I 1.741 1.00
33_T 81_I 1.668 1.00
106_V 109_N 1.641 1.00
52_E 56_G 1.641 1.00
62_T 87_N 1.606 1.00
41_L 56_G 1.545 1.00
92_Q 148_H 1.539 1.00
102_A 153_A 1.538 1.00
7_L 22_L 1.535 1.00
130_E 134_E 1.534 1.00
56_G 60_R 1.512 1.00
47_E 51_R 1.491 1.00
33_T 68_V 1.491 1.00
33_T 65_L 1.482 1.00
59_A 63_A 1.48 1.00
133_Q 137_E 1.475 1.00
83_L 142_L 1.468 1.00
25_S 161_I 1.453 1.00
56_G 59_A 1.447 1.00
157_P 161_I 1.442 1.00
85_E 89_H 1.438 1.00
83_L 138_E 1.415 1.00
8_I 146_V 1.405 0.99
99_Y 140_D 1.399 0.99
31_V 73_T 1.392 0.99
160_V 163_E 1.383 0.99
11_R 122_T 1.381 0.99
41_L 60_R 1.338 0.99
151_I 164_I 1.335 0.99
36_W 64_A 1.332 0.99
30_F 76_A 1.325 0.99
23_A 30_F 1.323 0.99
126_K 131_E 1.317 0.99
35_Q 38_Q 1.312 0.99
102_A 107_L 1.289 0.99
33_T 64_A 1.279 0.99
82_I 142_L 1.278 0.99
28_R 72_S 1.276 0.99
136_L 140_D 1.267 0.99
48_I 56_G 1.257 0.99
21_A 157_P 1.25 0.99
65_L 81_I 1.245 0.98
47_E 50_E 1.234 0.98
98_V 149_I 1.218 0.98
156_E 159_Q 1.217 0.98
25_S 162_S 1.215 0.98
10_P 107_L 1.203 0.98
99_Y 144_R 1.199 0.98
52_E 60_R 1.186 0.98
6_F 75_I 1.177 0.98
91_M 97_V 1.175 0.98
103_P 154_T 1.172 0.98
38_Q 44_T 1.17 0.97
18_V 161_I 1.166 0.97
62_T 65_L 1.157 0.97
65_L 91_M 1.147 0.97
129_S 133_Q 1.144 0.97
104_V 136_L 1.135 0.97
11_R 49_V 1.135 0.97
127_P 130_E 1.111 0.96
89_H 93_N 1.096 0.96
49_V 122_T 1.094 0.96
98_V 151_I 1.094 0.96
149_I 167_A 1.087 0.96
6_F 91_M 1.078 0.95
105_S 129_S 1.074 0.95
161_I 164_I 1.068 0.95
44_T 47_E 1.063 0.95
88_R 146_V 1.059 0.95
21_A 161_I 1.059 0.95
102_A 110_R 1.056 0.95
147_A 150_I 1.055 0.95
43_M 48_I 1.04 0.94
23_A 74_V 1.03 0.94
45_V 80_G 1.029 0.94
101_C 140_D 1.017 0.93
37_L 48_I 1.013 0.93
62_T 90_F 1.008 0.93
6_F 65_L 1.002 0.92
84_T 87_N 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nwjA20.98281000.415Contact Map0.694
1e6cA20.99431000.42Contact Map0.688
1viaA20.9541000.452Contact Map0.79
3trfA20.98281000.455Contact Map0.714
2pt5A40.9541000.456Contact Map0.82
2iyvA10.9771000.479Contact Map0.688
3vaaA30.98281000.488Contact Map0.722
1zuhA10.92531000.491Contact Map0.789
1kagA20.96551000.502Contact Map0.769
2axnA10.982899.90.522Contact Map0.217

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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